DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shark and Bmx

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001102486.1	Gene:	Bmx / 367786	RGDID:	1565643	Length:	655	Species:	Rattus norvegicus

Alignment Length:	788	Identity:	186/788 - (23%)
Similarity:	312/788 - (39%)	Gaps:	190/788 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 EDILKHLLNAKVQVNSSDSFGCQPLHYAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKH 231
            :.||:.||..|.|.....|    |::|    |...|:.|..|...        ..|..:...::.
  Rat     8 KSILEELLLKKSQQKKKMS----PINY----KERLFVLTKTSLSY--------YEYDKMKRGSRK 56

  Fly   232 GNLE-----AVQELLLAEAPPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHG 291
            |::|     .|:::.|.|..|:.|    ::||.:..:.|        |.|.......:|.||
  Rat    57 GSIEVKKIRCVEKVNLEEQTPVER----QYPFQIVYKDG--------LLYVYASNEESRCQW--- 106

  Fly   292 TLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQVVK-----NFRIS 351
                             |.|.|.|:..:...|::|.......|..  |.|.|..|     ....:
  Rat   107 -----------------LKALQKEIRGNPHLLIKYHSGFFVDGKF--LCCQQSCKAAPGCTLWEA 152

  Fly   352 QADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFAT 416
            .|||:             :.|.|..:                      :.|..|:...::|....
  Rat   153 YADLH-------------IAISDEKH----------------------RAPTFPERILKIPRAVP 182

  Fly   417 IPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMN 481
            |    :|..|:|.:..|.....|....:...|.:.|.                 ..|::...|..
  Rat   183 I----LKMDASSSSAIPPQYDSHLKKSYDSQPTVNIR-----------------YIPREDCPDWW 226

  Fly   482 SLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVY 546
            .:||.|     |:.:.:.|..|   |:.:.:.:|...|..|....|:...:.:......|.
  Rat   227 QIRKPK-----SEEDIARSNQL---ERNIVSHSPSKMSWGFPESSSSEEEENLDAYDWFAG---- 279

  Fly   547 NVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQW-IGNGYQPTMDVLSLLDQQI--K 608
            |:.|:.:                      ..:..::.:.|.: :.|..|..|..:||..:.:  |
  Rat   280 NISRSQS----------------------EQLLRQKGKEGAFMVRNSSQMGMYTVSLFSKAVNDK 322

  Fly   609 APAVARLNSLGPNASTESEMAS-----------YLHRKCSGTPST----PSATEVEAAKLR---- 654
            ...|...: :..||..:..:|.           :.|:..|....|    |.:|:.....:.
  Rat   323 KGTVKHYH-VHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPVSVALG 386

  Fly   655 ---FFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREAS 715
               :.::.|::.|.:|:|.|:||.|..| |         :.:..||:||:.:...::.||.:||.
  Rat   387 SGIWELKREEIALLKELGSGQFGVVQLGKW---------KGQYSVAVKMIKEGAMSEDEFFQEAQ 442

  Fly   716 VMMRLEHKCIVRLIGI-AKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHY 779
            .||:|.|..:|:..|: :|...:.:|.|....|.:|.|:.:||..:.::..|:: ...:..||.:
  Rat   443 TMMKLSHPKLVKFYGVCSKKYPIYIVTEYITNGCLLNYLKNHGKGLESSQLLEM-CYDVCEGMAF 506

  Fly   780 LESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIF 844
            |||..|:||||||||.|:.:....|:|||||:|.:.  ..:|..:.|.::|::|.|||.|:...:
  Rat   507 LESHQFIHRDLAARNCLVDSDLSVKVSDFGMTRYVL--DDQYVSSVGTKFPVKWSAPEVFHYFKY 569

  Fly   845 SHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPK 909
            |..||||:||:.:||:||||..||....|.:.:..|..|.||.:|.|....||.:|.|||.|.|:
  Rat   570 SSKSDVWAFGILMWEVFSLGKQPYDLYDNSEVVVKVSQGHRLYRPQLASDTIYQIMYSCWHELPE 634

  Fly   910 DRPTFVYL 917
            .||||..|
  Rat   635 KRPTFQQL 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560	6/16 (38%)
		ANK	117..241	CDD:238125	17/78 (22%)
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786	6/16 (38%)
		Ank_2	158..247	CDD:289560	19/84 (23%)
		ANK repeat	186..217	CDD:293786	6/30 (20%)
		ANK repeat	220..245	CDD:293786	5/29 (17%)
		Ank_4	224..274	CDD:290365	10/54 (19%)
		SH2_Cterm_shark_like	287..395	CDD:198211	18/112 (16%)
		TyrKc	662..921	CDD:197581	97/258 (38%)
		PTKc_Syk_like	666..926	CDD:270650	96/254 (38%)
Bmx	NP_001102486.1	PH_Btk	25..151	CDD:269944	34/175 (19%)
		PH	27..115	CDD:278594	26/131 (20%)
		SH2_Tec_Bmx	269..374	CDD:198262	18/131 (14%)
		PKc_like	392..647	CDD:304357	98/263 (37%)
		Pkinase_Tyr	397..646	CDD:285015	97/258 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810