DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shark and Itk

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001102295.2	Gene:	Itk / 363577	RGDID:	1311618	Length:	620	Species:	Rattus norvegicus

Alignment Length:	288	Identity:	103/288 - (35%)
Similarity:	156/288 - (54%)	Gaps:	30/288 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   636 CSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKML 700
            ||.....|....:...|  :.|:|.:|...:|||.|:||.||.|:.|.|.        :||||.:
  Rat   339 CSWRQKAPVTAGLRYGK--WVIQPSELTFVQEIGSGQFGLVHLGYWLNKD--------KVAIKTI 393

  Fly   701 SDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHG-------- 757
            .:...::::|:.||.|||:|.|..:|:|.|:.        .|.||:..:.:: ::||
  Rat   394 QEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVC--------LEQAPICLVFEF-MEHGCLSDYLRS 449

  Fly   758 -HEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEY 821
             ..:.|...|......:..||.|||....:||||||||.|:......|:|||||:|.:.  ..:|
  Rat   450 QRGLFAAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVL--DDQY 512

  Fly   822 QFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERL 886
            ..:.|.::|::|.:||.|:...:|..||||||||.:||:||.|..||...||.:.::.:.:|.||
  Rat   513 TSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRL 577

  Fly   887 PQPNLCPAYIYAVMQSCWKERPKDRPTF 914
            .:|.|...::|.||..||||:|:|||.|
  Rat   578 YKPRLASPHVYQVMNHCWKEKPEDRPPF 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560
		ANK	117..241	CDD:238125
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		Ank_2	158..247	CDD:289560
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		Ank_4	224..274	CDD:290365
		SH2_Cterm_shark_like	287..395	CDD:198211
		TyrKc	662..921	CDD:197581	97/262 (37%)
		PTKc_Syk_like	666..926	CDD:270650	96/258 (37%)
Itk	NP_001102295.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810