Protein Alignment Shark and Src42A

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_001400996.1
• Gene: Src42A / 35524
• FlyBaseID: FBgn0264959
• Length: 1606
• Species: Drosophila melanogaster
• Alignment Length: 982
• Identity: 225/982 - (22%)
• Similarity: 367/982 - (37%)
• Gaps: 293/982 - (29%)

  Fly    68 AFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHG-VTNLLHRATSKN 131
            :::..:.|:..|:::|  |:.|..|: .|.:..|.          ....::| :..:|||.||::
  Fly   792 SYYRRNFKIYDKLVYG--TIYDIIQR-KNDIYQKY----------DKYMTYGTIYEILHRKTSQS 843

  Fly   132 ----ESKVVFELLKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSFGCQPLH 192
                :.|.:..:|:.|..:.|.....||..      ..|:..|....:|.|...:...:|
  Fly   844 SDPWQRKSLSSILEGGRSSGDIIYDIGQRR------ERDKRTLGSSSSATVSTINPHKYG----- 897

  Fly   193 YAARSKPASFIRTLISAQANVQGRNIDNGYV-------------PLHEAAKHGNLEAVQELLLAE 244
                        |:...   :||..||.|:|             ||   ||.......|.:...:
  Fly   898 ------------TIYDI---LQGVKIDAGHVKNKPDQKSKPTKPPL---AKPTRFVVSQVVEPVQ 944

  Fly   245 APPLPRTSSGEFPFDLAKEAGQTAVEE---------------FLLNYKLPPANTTRDQWYHGTLT 294
            .||             ..::|::..|:               .:|:|.   .|:..||  ..|..
  Fly   945 IPP-------------TDQSGKSVQEQGAPKSNKPNKMRRLSNILSYS---RNSGEDQ--QETTG 991

  Fly   295 REEAV--------------AILKKHAKEL----LAKQPEVDTSGCFLVRYSESPAASGLVLTLLC 341
            :||..              .:|...::||    :|:|..:|.      .:|:.|.........:|
  Fly   992 KEETKPKRTQAKRRIGVTNLLLPLDSEELYTRIIAQQRGLDK------EHSQEPEEKCASEEQMC 1050

  Fly   342 DQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVS-LKYPVPP 405
            .:                |.:....|    :|                ..|..:.:| ...|.||
  Fly  1051 TR----------------NALTKSSS----LD----------------AISLSVAISPASSPSPP 1079

  Fly   406 QPKPEVPSFATIPRSNMKPKA-----------ASPATPPTPVSPHSHHQ------HP---HVPAL 450
            :|:..:.....:.:....|.|           .|..|...|:...|:..      ||   .:|..
  Fly  1080 RPRRSLKQHRCLQQHQQTPLAKKHSLDNCLQVVSSTTSRQPLRRWSNQTPLKCTCHPATEELPLT 1144

  Fly   451 TITKKK---------------------QKENSSSMFNTLRLTSPKK------ALFDMNSLRKNKS 488
            .|.|.:                     |...::..|....||:.||      :.|........||
  Fly  1145 AIEKSRSLPAACSASCSHTCAHLSVIDQSPATTKCFGKTSLTTAKKGKSRRLSEFTRGEFLNEKS 1209

  Fly   489 ----KGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVP 549
                |.||.::|.    .|...|.| ..|..:..|.|...::|....||.|       .:.|.:.
  Fly  1210 WYFRKIKRIEAEK----KLLLPENE-HGAFLIRDSESRHNDYSLSVRDGDT-------VKHYRIR 1262

  Fly   550 RNNTPIEIDLPP--IAQKT-----EAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQI 607
                  ::|...  ||::|     :..||:::|..                    |.|.:   .:
  Fly  1263 ------QLDEGGFFIARRTTFRTLQELVEHYSKDS--------------------DGLCV---NL 1298

  Fly   608 KAPAVARLNSLGPNASTESEMASYL-HRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHG 671
            ..|.| :.||.......|..:...| ||       |....|::...|:|.         |::|.|
  Fly  1299 CKPCV-QTNSFSGVFEIEKPVTEGLSHR-------TRDQWEIDRTSLKFV---------RKLGSG 1346

  Fly   672 EFGSVHSG-WLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAK-G 734
            :||.|..| |         .:...||||.|.....:.::||.||.:|.:|.|..:::|..:.. .
  Fly  1347 QFGDVWEGLW---------NNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVE 1402

  Fly   735 EMLMMVQELAPLGSMLQY---ILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNIL 796
            |.:.::.||...||:|:|   |...|..:.....:.: |:|||.||.|||||:::||||||||:|
  Fly  1403 EPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDM-AAQIAAGMAYLESQNYIHRDLAARNVL 1466

  Fly   797 LTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMF 861
            :...:..||:|||::|.::  ..||:...|.|:||:|.|||:.|...||..|||||||:.:.|:.
  Fly  1467 VGDGNIVKIADFGLARLIK--EDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELV 1529

  Fly   862 SLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFV----YLTEFFA 922
            :.|..||..::|.:.:..|:.|.|:|||..|...:|.:|..||.:.|..||||.    .|.:|:.
  Fly  1530 TYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYT 1594

  Fly   923 RD-PDYQ 928
            .| .||:
  Fly  1595 SDQSDYK 1601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	5/22 (23%)
		ANKYR	<94..317	CDD:440430	48/273 (18%)
		ANK repeat	124..151	CDD:293786	9/30 (30%)
		ANK repeat	153..184	CDD:293786	6/30 (20%)
		ANK repeat	186..217	CDD:293786	4/30 (13%)
		ANK repeat	220..245	CDD:293786	7/37 (19%)
		SH2_Cterm_shark_like	287..395	CDD:198211	17/125 (14%)
		PTKc_Syk_like	666..926	CDD:270650	100/269 (37%)
Src42A	NP_001400996.1	SH2_Src_Src42	1210..1301	CDD:198233	24/131 (18%)
		PTKc_Frk_like	1328..1596	CDD:270653	102/288 (35%)