DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shark and Src42A

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_610191.2	Gene:	Src42A / 35524	FlyBaseID:	FBgn0264959	Length:	1597	Species:	Drosophila melanogaster

Alignment Length:	981	Identity:	223/981 - (22%)
Similarity:	366/981 - (37%)	Gaps:	300/981 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 AFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHG-VTNLLHRATSKN 131
            :::..:.|:..|:::|  |:.|..|: .|.:..|.          ....::| :..:|||.||::
  Fly   792 SYYRRNFKIYDKLVYG--TIYDIIQR-KNDIYQKY----------DKYMTYGTIYEILHRKTSQS 843

  Fly   132 ----ESKVVFELLKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSFGCQPLH 192
                :.|.:..:|:.|..:.|.....||..      ..|:..|....:|.|...:...:|
  Fly   844 SDPWQRKSLSSILEGGRSSGDIIYDIGQRR------ERDKRTLGSSSSATVSTINPHKYG----- 897

  Fly   193 YAARSKPASFIRTLISAQANVQGRNIDNGYV-------------PLHEAAKHGNLEAVQELLLAE 244
                        |:...   :||..||.|:|             ||   ||.......|.:...:
  Fly   898 ------------TIYDI---LQGVKIDAGHVKNKPDQKSKPTKPPL---AKPTRFVVSQVVEPVQ 944

  Fly   245 APPLPRTSSGEFPFDLAKEAGQTAVEE---------------FLLNYKLPPANTTRDQWYHGTLT 294
            .||             ..::|::..|:               .:|:|.   .|:..||  ..|..
  Fly   945 IPP-------------TDQSGKSVQEQGAPKSNKPNKMRRLSNILSYS---RNSGEDQ--QETTG 991

  Fly   295 REEAV--------------AILKKHAKEL----LAKQPEVDTSGCFLVRYSESPAASGLVLTLLC 341
            :||..              .:|...::||    :|:|..:|.      .:|:.|.........:|
  Fly   992 KEETKPKRTQAKRRIGVTNLLLPLDSEELYTRIIAQQRGLDK------EHSQEPEEKCASEEQMC 1050

  Fly   342 DQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVS-LKYPVPP 405
            .:                |.:....|    :|                ..|..:.:| ...|.||
  Fly  1051 TR----------------NALTKSSS----LD----------------AISLSVAISPASSPSPP 1079

  Fly   406 QPKPEVPSFATIPRSNMKPKA-----------ASPATPPTPVSPHSHHQ------HP---HVPAL 450
            :|:..:.....:.:....|.|           .|..|...|:...|:..      ||   .:|..
  Fly  1080 RPRRSLKQHRCLQQHQQTPLAKKHSLDNCLQVVSSTTSRQPLRRWSNQTPLKCTCHPATEELPLT 1144

  Fly   451 TITKKK---------------------QKENSSSMFNTLRLTSPKK------ALFDMNSLRKNKS 488
            .|.|.:                     |...::..|....||:.||      :.|........||
  Fly  1145 AIEKSRSLPAACSASCSHTCAHLSVIDQSPATTKCFGKTSLTTAKKGKSRRLSEFTRGEFLNEKS 1209

  Fly   489 ----KGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVP 549
                |.||.::|.    .|...|.| ..|..:..|.|...::|....||.|       .:.|.:.
  Fly  1210 WYFRKIKRIEAEK----KLLLPENE-HGAFLIRDSESRHNDYSLSVRDGDT-------VKHYRIR 1262

  Fly   550 RNNTPIEIDLPP--IAQKT-----EAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQI 607
                  ::|...  ||::|     :..||:::|....:        ..|..:|.:        ||
  Fly  1263 ------QLDEGGFFIARRTTFRTLQELVEHYSKDSDGL--------CVNLCKPCV--------QI 1305

  Fly   608 KAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGE 672
            :.|....|:                ||       |....|::...|:|.         |::|.|:
  Fly  1306 EKPVTEGLS----------------HR-------TRDQWEIDRTSLKFV---------RKLGSGQ 1338

  Fly   673 FGSVHSG-WLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAK-GE 735
            ||.|..| |         .:...||||.|.....:.::||.||.:|.:|.|..:::|..:.. .|
  Fly  1339 FGDVWEGLW---------NNTTPVAIKTLKSGTMDPKDFLAEAQIMKKLRHTKLIQLYAVCTVEE 1394

  Fly   736 MLMMVQELAPLGSMLQY---ILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILL 797
            .:.::.||...||:|:|   |...|..:.....:.: |:|||.||.|||||:::||||||||:|:
  Fly  1395 PIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDM-AAQIAAGMAYLESQNYIHRDLAARNVLV 1458

  Fly   798 TARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFS 862
            ...:..||:|||::|.::  ..||:...|.|:||:|.|||:.|...||..|||||||:.:.|:.:
  Fly  1459 GDGNIVKIADFGLARLIK--EDEYEARVGARFPIKWTAPEAANYSKFSIKSDVWSFGILLTELVT 1521

  Fly   863 LGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFV----YLTEFFAR 923
            .|..||..::|.:.:..|:.|.|:|||..|...:|.:|..||.:.|..||||.    .|.:|:..
  Fly  1522 YGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKDPMRRPTFETLQWKLEDFYTS 1586

  Fly   924 D-PDYQ 928
            | .||:
  Fly  1587 DQSDYK 1592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	5/22 (23%)
		Ank_2	<112..184	CDD:289560	16/76 (21%)
		ANK	117..241	CDD:238125	29/141 (21%)
		ANK repeat	124..151	CDD:293786	9/30 (30%)
		ANK repeat	153..184	CDD:293786	6/30 (20%)
		Ank_2	158..247	CDD:289560	17/101 (17%)
		ANK repeat	186..217	CDD:293786	4/30 (13%)
		ANK repeat	220..245	CDD:293786	7/37 (19%)
		Ank_4	224..274	CDD:290365	9/64 (14%)
		SH2_Cterm_shark_like	287..395	CDD:198211	17/125 (14%)
		TyrKc	662..921	CDD:197581	98/267 (37%)
		PTKc_Syk_like	666..926	CDD:270650	100/269 (37%)
Src42A	NP_610191.2	SH2_Src_Src42	1210..1301	CDD:198233	23/116 (20%)
		PTKc_Frk_like	1319..1587	CDD:270653	102/288 (35%)
		Pkinase_Tyr	1328..1580	CDD:285015	99/272 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468392
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	148	1.000	Inparanoid score	I1725
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.990