DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shark and CG10702

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001188841.1	Gene:	CG10702 / 35181	FlyBaseID:	FBgn0032752	Length:	946	Species:	Drosophila melanogaster

Alignment Length:	175	Identity:	41/175 - (23%)
Similarity:	61/175 - (34%)	Gaps:	58/175 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    71 SIDDKVQTKILHGLD--TLVDYY--------QQAAN------GLPTKLT----------VPLIRD 109
            |||.:.:.|.:|.||  |:|..|        :|..|      .|.|::|          :..|.:
  Fly    32 SIDIRNECKNMHLLDNCTVVTGYVMITLITIEQRCNFSEYSYPLLTEITEFMIFTDVRGLVNITE 96

  Fly   110 LPPHNTRSHGVTNLLHRA---TSKNE-SKVVF-----------------ELLKCGYRNFDAKNQD 153
            :.||.|...|....|:.|   |:.:| .::||                 :|...|..|:|.
  Fly    97 MFPHLTVIRGRRLFLNYALGVTNMHELEQLVFPKLVAIQRGQVYIGSCPKLCSIGRVNWDL---- 157

  Fly   154 GQTALHLAALHSDEDILKHLLNAKVQVNSS-DSFGCQPLHYAARS 197
                  |.....:.:|:....|....|.|. .|..|...||..||
  Fly   158 ------LTLTRGENNIIMVNKNCSTPVCSGCSSSHCWSNHYCQRS 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	9/21 (43%)
		Ank_2	<112..184	CDD:289560	19/93 (20%)
		ANK	117..241	CDD:238125	22/103 (21%)
		ANK repeat	124..151	CDD:293786	10/47 (21%)
		ANK repeat	153..184	CDD:293786	5/31 (16%)
		Ank_2	158..247	CDD:289560	11/41 (27%)
		ANK repeat	186..217	CDD:293786	5/12 (42%)
		ANK repeat	220..245	CDD:293786
		Ank_4	224..274	CDD:290365
		SH2_Cterm_shark_like	287..395	CDD:198211
		TyrKc	662..921	CDD:197581
		PTKc_Syk_like	666..926	CDD:270650
CG10702	NP_001188841.1	Recep_L_domain	47..159	CDD:279382	23/121 (19%)
		Furin-like	171..297	CDD:279142	9/26 (35%)
		FU	210..258	CDD:238021
		Recep_L_domain	328..441	CDD:279382
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468387
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930