DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and Btk29A

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001097121.1 Gene:Btk29A / 34132 FlyBaseID:FBgn0003502 Length:786 Species:Drosophila melanogaster


Alignment Length:909 Identity:210/909 - (23%)
Similarity:330/909 - (36%) Gaps:285/909 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   122 NLLHRATSKNESKVV------FELLKCGYRNFDAKNQDGQT---ALHLAALHSDEDILKHLLNAK 177
            :::.||.:|.....|      |||.|..:..||.:|.:.:.   .:||..:...|:       |.
  Fly    47 SMVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEE-------AT 104

  Fly   178 VQVNSSDSFGCQPLHYAARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLL 242
            |.....|.|       |....|.......|||.||  ...::||                     
  Fly   105 VSGEGGDPF-------APDGYPFQVGYCEISASAN--SHQLENG--------------------- 139

  Fly   243 AEAPPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQW------------------Y 289
                     :.|.....:..:....||.::.| |.:..:...|.:|                  |
  Fly   140 ---------NGGGSGVGIEGQQSGRAVPQYTL-YVIANSEKERSEWIRAIRQVCEDSNTPKSYRY 194

  Fly   290 HGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRY----------SESPAASGLVLTLLCDQV 344
            |..|...:..:..|..::         .|.||....:          ..|||.:. ..::..:..
  Fly   195 HPGLWSGKKWSCCKGLSR---------TTFGCRAAAHWREANNNPSNGSSPAQNS-TRSISPNSS 249

  Fly   345 VKNFRISQADLYQN---------GNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGL----- 395
            ..|   ||..|..|         |..:..||                         |.||     
  Fly   250 TTN---SQFSLQHNSSGSLGGGVGGGLGGGG-------------------------SLGLGGGGG 286

  Fly   396 ------PVSLKYPVPPQPKPEVPSF----------ATIPRSNMKPKAASPATPPTPVSPHSHHQH 444
                  |.||      ||:..:.:|          .|:..:||      |...|||.:|:|    
  Fly   287 GGGSCTPTSL------QPQSSLTTFKQSPTLLNGNGTLLDANM------PGGIPTPGTPNS---- 335

  Fly   445 PHVPALTITKKKQKENSSSMFNTLRLTSPKKAL--FDMNSLRKNKSKGKRSDSES---SVSGSLA 504
                       |.|:||..:...:.| .|.||:  .|: ||.||.......||:.   .|..:| 
  Fly   336 -----------KAKDNSHFVKLVVAL-YPFKAIEGGDL-SLEKNAEYEVIDDSQEHWWKVKDAL- 386

  Fly   505 GTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAE 569
                                                  |.|..:|.|.      :.|.|......
  Fly   387 --------------------------------------GNVGYIPSNY------VKPKALLGLER 407

  Fly   570 VEYFTKSDVAIERERAGQWIGNGYQPTMDV--------LSLLDQQIKAP-AVARLNSLGPNASTE 625
            .|::...   :.|:||...:..|.:....|        |..|....|.| :..:...:..||..|
  Fly   408 YEWYVGD---MSRQRAESLLKQGDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARCE 469

  Fly   626 ------------SEMASYLHRKCSG------------TPSTPSATEVEAAKLRFFIEPEKLVLDR 666
                        .::.:| ||..||            .|..|:|   ..:..::.|.|.:|:|..
  Fly   470 YYLSEKHCCETIPDLINY-HRHNSGGLACRLKSSPCDRPVPPTA---GLSHDKWEIHPMELMLME 530

  Fly   667 EIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIG 730
            |:|.|:||.|..| |         ...::.|:||:.:...::.:|:.||.||.:|:|..:|:|.|
  Fly   531 ELGSGQFGVVRRGKW---------RGSIDTAVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYG 586

  Fly   731 I-AKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKV-WASQIACGMHYLESQHFVHRDLAAR 793
            : :|...:.:|.|....||:|.|:..|...:..|..|.: ...|::.||.|||..:::|||||||
  Fly   587 VCSKHRPIYIVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAAR 651

  Fly   794 NILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIW 858
            |.|:.:.:..|::|||::|.:.  ..:|..:.|.::||:|..||..|...||..||||::||.:|
  Fly   652 NCLVGSENVVKVADFGLARYVL--DDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMW 714

  Fly   859 EMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFFA 922
            |:|:.|..|||.:.|.:.::.|..|..|.:|..|...||.||:.||...|::||.|..|.:..|
  Fly   715 EIFTCGKMPYGRLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLA 778

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560 16/70 (23%)
ANK 117..241 CDD:238125 27/127 (21%)
ANK repeat 124..151 CDD:293786 10/32 (31%)
ANK repeat 153..184 CDD:293786 5/33 (15%)
Ank_2 158..247 CDD:289560 16/88 (18%)
ANK repeat 186..217 CDD:293786 8/30 (27%)
ANK repeat 220..245 CDD:293786 2/24 (8%)
Ank_4 224..274 CDD:290365 3/49 (6%)
SH2_Cterm_shark_like 287..395 CDD:198211 20/144 (14%)
TyrKc 662..921 CDD:197581 93/261 (36%)
PTKc_Syk_like 666..926 CDD:270650 92/260 (35%)
Btk29ANP_001097121.1 PH_Btk 44..222 CDD:269944 41/230 (18%)
SH3_Tec_like 346..399 CDD:212702 17/99 (17%)
SH2_Tec_family 403..505 CDD:198188 18/105 (17%)
PTKc_Tec_like 521..778 CDD:173637 95/267 (36%)
Pkinase_Tyr 526..777 CDD:285015 93/261 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45468348
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24418
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.840

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