DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shark and hop

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_511119.2	Gene:	hop / 32080	FlyBaseID:	FBgn0004864	Length:	1177	Species:	Drosophila melanogaster

Alignment Length:	1189	Identity:	273/1189 - (22%)
Similarity:	431/1189 - (36%)	Gaps:	373/1189 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 DGTFLVRESSTAAGDFVL---SLLCQGEVCH---------------YQVRRHGGE---DAFFSID 73
            |||  :|..:...|:|..   ::||: |:|:               |.:|.|...   .....:|
  Fly    45 DGT--IRVFNFTTGEFERFHPNMLCE-EICNTMCRQLGIAPIAQLLYGIREHSTSRRPSPLVRLD 106

  Fly    74 -------DKVQTKILH---------GLDT---LVD------YYQQAANGLPTKLTVPLIRDLPPH 113
                   :::..::::         .||:   |:|      .|:|....:.|: .:|.|| .|.|
  Fly   107 LTWCLPGERLNCQLVYCFRMRFRVPELDSQLELIDGRSHKFLYRQMRYDMRTE-QIPEIR-YPEH 169

  Fly   114 NTRSHG--VTNLLHRATSKNE-----------------------------SKV--VFELLKCGYR 145
            ..:|.|  |.::|.....::|                             ||:  ||..||....
  Fly   170 KDKSTGLAVMDMLIDDQEQSEDQQAMRSIEKLYKLYLPPSLWRAHSFFVGSKIREVFRSLKANSL 234

  Fly   146 NFD-AKNQDGQTALHLAALHSDEDI---LKHLLNAKVQVNSSDSFGCQPLHYAARSKPASFIRTL 206
            :.: .|........|||..:..|..   :::|.|.:| ...|...|....|..:....:....||
  Fly   235 SVERLKWHYVHQVSHLAPTYMTEQFTCTVQYLPNEEV-ARGSGPIGTSLAHSTSTLASSGSTNTL 298

  Fly   207 ISAQANVQG------------RNIDNG---YVPL--HEAAKHG------NLEAVQELLLA----- 243
            .:...|...            |:...|   ||.:  |::.:.|      ..||..:.:|.
  Fly   299 STLTTNTNSVALGGSGKKAKRRSTSGGIDVYVRVFPHDSLEPGLKVARVTSEATLKWILVGAVEG 363

  Fly   244 --------------EAPPLPRTSSGEFPFDLAKE-------------AGQTAVEEFLLNYKLPPA 281
                          |...||:  ..|..|...||             .....:::...:|:.|..
  Fly   364 IFMISKINDTSVRLEIVGLPK--GYEMQFQTEKEMKSFISYLGIYIRLSSKWMQDLCHSYRTPSL 426

  Fly   282 NTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESP------AASGLVLTLL 340
            ........||.:  ..|.:::|.|...        |..|.::||..:..      ..:..::...
  Fly   427 EELSSLHCHGPI--GGAYSLMKLHENG--------DKCGSYIVRECDREYNIYYIDINTKIMAKK 481

  Fly   341 CDQ---VVKNFRISQAD-----LYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFS----Y 393
            .||   ..:.|||.:.|     .|.||..|.:.                .|.:||.::..    |
  Fly   482 TDQERCKTETFRIVRKDSQWKLSYNNGEHVLNS----------------LHEVAHIIQADSPDRY 530

  Fly   394 GLPVSLKYPVPPQPKPEVP------------SFATIPRSNMKPKAASPATP----PTPVSPHSH- 441
            .:|.| ||..||.....:|            |.|.:.|.|  |:..:|.|.    |..:|....
  Fly   531 RIPAS-KYDKPPLLLLLLPKNLKAKKTDLQLSEAELQRRN--PQIFNPRTDLQWYPDSISLSDDG 592

  Fly   442 ----------HQHPHVPALTITKKKQKENSSSM-FNTLRLT-----SPK------KALFDMNSLR 484
                      .|.| |..:::|.|..|.:.:.| |..|..|     ||:      ..|.|..::.
  Fly   593 MMFTMRGDWIQQSP-VKDVSVTMKMLKSDGNFMEFFRLAQTWSLIQSPQFLKLYGLTLADPYTMV 656

  Fly   485 KNKSK----GKRSDSESSVS---------GSLAGTE--QELQAAAPMLK-SLSFSTEF--STFNA 531
            ...|:    .|...|..:|:         |.:.|..  ::.:.....:: |..:.|::  :::..
  Fly   657 MEYSRYGPLNKFLHSMPNVTLHCLLDLMHGLVRGMHYLEDNKIIHNYIRCSNLYVTKYDPNSYVL 721

  Fly   532 DGVTGSGAAAAGEVYNVPRNNTPIEIDLP--PI-------AQKTE--AEV--------EYFT--K 575
            |      |..:...|..|..    |.|.|  |:       |.||:  |::        |.|:  |
  Fly   722 D------AKISDPGYPRPYR----ESDSPWIPVKYYRNLQAAKTDQFAQLWAFATTIYEIFSRCK 776

  Fly   576 SDVAIERE----RAGQWIGNGYQPTMDVLSLLDQQIKAPA-----------------------VA 613
            .|::..|:    |.....||       :|.:|||.| .||                       .:
  Fly   777 EDLSTLRQEQLLRQKNLDGN-------ILKMLDQDI-CPAPIFETIMDGWSDDETKRFSHHDIFS 833

  Fly   614 RLNSLG----PNASTESEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVL---------- 664
            |||::.    ||.....|:|         |..|...|.::.:.:.|...|...:|
  Fly   834 RLNTIKAEILPNYMPPPEIA---------TNGTGDETVIDRSDIPFLPFPRSNMLMVIPLTSECR 889

  Fly   665 -----DREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKC 724
                 :..||.|.:|:|:.|.|  :....::.|.:||||||:....: .:|.||..:|..|.|..
  Fly   890 VIYNMENMIGRGHYGTVYKGHL--EFNDKDQPREQVAIKMLNTMQVS-TDFHREIGIMRTLSHPN 951

  Fly   725 IVRL-IGIAKGEMLMMVQELAPLGSMLQYILDHGHEITA----NAELKVWASQIACGMHYLESQH 784
            ||:. ....|...::|  |....||...|:     ..||    |..|..:|..||.||.||....
  Fly   952 IVKFKYWAEKSHCIIM--EYLQSGSFDIYL-----RFTAPNLNNPRLVSFALDIANGMKYLSDMG 1009

  Fly   785 FVHRDLAARNILLTARHQ-----AKISDFGMSRSLRPGSTEYQFTQGGR-WPIRWYAPESFNLGI 843
            .:||||||||||:.  |.     .||||||:::.  ..|..|.:.:..| .|||||:||:.:...
  Fly  1010 LIHRDLAARNILVD--HNGDGDCVKISDFGLAQF--ANSDGYYYAKSKRDIPIRWYSPEAISTCR 1070

  Fly   844 FSHASDVWSFGVTIWEMFSLGAPPY---GEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWK 905
            ||..|||||:|||::||||.|..|.   .:.|..|.:..:.|||||.:|..||.:||.:||.||.
  Fly  1071 FSSYSDVWSYGVTLFEMFSRGEEPNLVPIQTSQEDFLNRLQSGERLNRPASCPDFIYDLMQLCWH 1135

  Fly   906 ERPKDRPTFVYLTEFFARD 924
            ..|:.||:|..:.:...|:
  Fly  1136 ATPRSRPSFATIVDIITRE 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	18/106 (17%)
		Ank_2	<112..184	CDD:289560	20/108 (19%)
		ANK	117..241	CDD:238125	33/183 (18%)
		ANK repeat	124..151	CDD:293786	8/58 (14%)
		ANK repeat	153..184	CDD:293786	7/33 (21%)
		Ank_2	158..247	CDD:289560	23/133 (17%)
		ANK repeat	186..217	CDD:293786	5/42 (12%)
		ANK repeat	220..245	CDD:293786	8/54 (15%)
		Ank_4	224..274	CDD:290365	12/89 (13%)
		SH2_Cterm_shark_like	287..395	CDD:198211	23/125 (18%)
		TyrKc	662..921	CDD:197581	103/287 (36%)
		PTKc_Syk_like	666..926	CDD:270650	103/273 (38%)
hop	NP_511119.2	B41	39..259	CDD:214604	42/218 (19%)
		SH2_Jak_family	420..516	CDD:198177	21/121 (17%)
		PTK_Jak_rpt1	584..836	CDD:270633	51/270 (19%)
		PTKc_Jak_rpt2	886..1155	CDD:270634	103/283 (36%)
		TyrKc	894..1151	CDD:197581	102/270 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900