DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shark and Lck

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	XP_006238994.1	Gene:	Lck / 313050	RGDID:	2994	Length:	520	Species:	Rattus norvegicus

Alignment Length:	777	Identity:	175/777 - (22%)
Similarity:	269/777 - (34%)	Gaps:	320/777 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   188 CQPLHY---AARSKPASFIRT-------LISAQANVQGRN--IDNGYVPLH--EAAKHGNL--EA 236
            |:..||   ...||....|||       |::.:.::...:  .||..:.||  |.:..|:|  |.
  Rat    31 CENCHYPIVPLDSKSTLPIRTGSEVRDPLVTYEGSLPPASPLQDNLVIALHSYEPSHDGDLGFEK 95

  Fly   237 VQELLLAE-------APPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLT 294
            .::|.:.|       |..|.....|..||:...:|.           .|.|     :.|:...|:
  Rat    96 GEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN-----------SLEP-----EPWFFKNLS 144

  Fly   295 REEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQ----VVKNFRISQADL 355
            |::|       .::|||..   :|.|.||:|.|||.|.|..:.....||    |||:::|...|
  Rat   145 RKDA-------ERQLLAPG---NTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLD- 198

  Fly   356 YQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRS 420
                    :||   .||.....:|.:..|:.|:...|.||...|..|...| ||:.|.:
  Rat   199 --------NGG---FYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQ-KPQKPWW------ 245

  Fly   421 NMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRK 485

  Rat   246 ----------------------------------------------------------------- 245

  Fly   486 NKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPR 550
                                 |.|                                    :.|||
  Rat   246 ---------------------EDE------------------------------------WEVPR 253

  Fly   551 NNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARL 615

  Rat   254 ----------------------------------------------------------------- 253

  Fly   616 NSLGPNASTESEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGW 680
                                                        |.|.|...:|.|:||.|..|:
  Rat   254 --------------------------------------------ETLKLVERLGAGQFGEVWMGY 274

  Fly   681 LLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAP 745
            .        ....:||:|.|.....:...||.||::|.:|:|..:|||..:...|.:.::.|...
  Rat   275 Y--------NGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQEPIYIITEYME 331

  Fly   746 LGSMLQYI-LDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFG 809
            .||::.:: ...|.::..|..|.: |:|||.||.::|.|:::||||.|.|||::.....||:|||
  Rat   332 NGSLVDFLKTPSGIKLNVNKLLDM-AAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFG 395

  Fly   810 MSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNV 874
            ::|.:.  ..||...:|.::||:|.|||:.|.|.|:..|||||||:.:.|:.:.|..||..::|.
  Rat   396 LARLIE--DNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNP 458

  Fly   875 DAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVY----LTEFF-ARDPDYQNLP 931
            :.|:.::.|.|:.:|:.||..:|.:|..||||||:|||||.|    |.:|| |.:..||..|
  Rat   459 EVIQNLEKGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLDDFFTATEGQYQPQP 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560
		ANK	117..241	CDD:238125	17/68 (25%)
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		Ank_2	158..247	CDD:289560	20/81 (25%)
		ANK repeat	186..217	CDD:293786	9/38 (24%)
		ANK repeat	220..245	CDD:293786	9/35 (26%)
		Ank_4	224..274	CDD:290365	14/60 (23%)
		SH2_Cterm_shark_like	287..395	CDD:198211	32/111 (29%)
		TyrKc	662..921	CDD:197581	96/263 (37%)
		PTKc_Syk_like	666..926	CDD:270650	97/265 (37%)
Lck	XP_006238994.1	SH3_Lck	76..129	CDD:212938	13/52 (25%)
		SH2_Src_Lck	134..234	CDD:198225	36/126 (29%)
		PTKc_Lck_Blk	248..511	CDD:270652	103/418 (25%)
		Pkinase_Tyr	256..505	CDD:285015	95/259 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810