DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shark and jak1

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_571148.1	Gene:	jak1 / 30280	ZFINID:	ZDB-GENE-980526-142	Length:	1153	Species:	Danio rerio

Alignment Length:	1161	Identity:	249/1161 - (21%)
Similarity:	397/1161 - (34%)	Gaps:	400/1161 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 HYQVR-----RHGGEDAFFSIDDKV-------QTKILHGLDTLVDYYQQAANGLPTKLTVPL--- 106
            ||::|     .||..:    |:..|       |..:|:.        |:...|.|......|
Zfish   104 HYRMRFYFTNWHGTSE----IESPVWRHTLSKQKSVLNS--------QKTTEGTPLLDAASLDYL 156

  Fly   107 --------IRDL----PPHNTRSH----------GVTNLLHRATSKNESKVVFELLKCG----YR 145
                    :|.|    |..|...|          .|..:.|.|.|.|     ..|...|    |:
Zfish   157 FAQGQYDFLRGLSPVRPTQNDEEHREIENECLGMAVLAITHHAKSNN-----LPLSGAGAETSYK 216

  Fly   146 NF--DAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNS----SDSFGCQPLHYAARSKPASFIR 204
            .|  |:.|:..:....|..:.. .::.|:.||   :.||    ..:.|.    |..:.|..|.:.
Zfish   217 RFIPDSLNRTIKQRNFLTRIRI-SNVFKNFLN---EFNSKTIQDSNIGL----YDLKVKYLSTLE 273

  Fly   205 TLISAQANVQGRNI-----------------------DNGYVPLHEAAKHGNL-------EAVQE 239
            ||...    .||.|                       |||..  :|...:|..       .|..:
Zfish   274 TLTQG----VGREIFKPKNLKVTGESEGSPAQMLPLGDNGMG--YEVQVYGTTGISWRRKPAPNQ 332

  Fly   240 LLLAEAPPLPRTSSGEFPFDLAKEAGQTAVEEF------------LLNYKLPPANTTRDQWY--- 289
            |:|.:.|...:....:...|..|::|.|...:|            :..|:........|.:|
Zfish   333 LILKDKPKSKKIKGDKQWNDKKKDSGWTLFSDFHEITHIVIKDCCVTIYRQDNKTMELDLFYRDA 397

  Fly   290 ---------------------------------------HGTLTREEAVAILKKHAKELLAKQPE 315
                                                   ||.:..|.|:..|::...|
Zfish   398 ALSFAALVDGYFRLTVDAHHYLCTDVAPSSVVQNLENGCHGPICTEYAIHKLRQEGNE------- 455

  Fly   316 VDTSGCFLVRYSESPAASGLVLTLLCDQV----------VKNFRISQADLYQNGNKVQSGGSKFL 370
               .|.:::|:| ....:.:::|::|.::          .|||:|..:   ..|.:        |
Zfish   456 ---EGTYVLRWS-CTEYNFIIMTVVCIELDLCESRPVPQYKNFQIETS---PQGYR--------L 505

  Fly   371 YIDDGPYWPSVEHLIAHF---------MRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKA 426
            |..| .:.|:::.|:.|.         :||      .|:...||||: |:.:...:
Zfish   506 YGTD-TFRPTLKELLEHLQGQLLRTDNLRF------QLRRCCPPQPR-EISNLLVM--------- 553

  Fly   427 ASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMNSL----RKNK 487
               .|...||                   .||:...|..:..|:.  |:.:.....|    |.|.
Zfish   554 ---TTDREPV-------------------PQKKTQVSQLSFDRIL--KEEIVQGEHLGRGTRTNI 594

  Fly   488 SKG---KRSDSESSVSGSLAGTEQELQAAAPMLK------SLSFSTEFSTFNADGVTGSGAAAAG 543
            ..|   .:||.|.    .|.|..||::....:|.      ||:|   |.|  |..:.........
Zfish   595 YAGILKPKSDDED----DLGGYSQEVKVVLKVLGSGHRDISLAF---FET--ASMMRQISHKHIA 650

  Fly   544 EVYNV---PRNNTPIE-------IDLPPIAQKTEAEVEYFTKSDVAIERERAGQWIG-----NGY 593
            .:|.|   .:.|..:|       :||....|.|.....:  |..||.:...|..::.     :||
Zfish   651 LLYGVCVRHQENIMVEEFVQYGPLDLFMRRQTTPLSTAW--KFQVAKQLASALSYLEDKKMVHGY 713

  Fly   594 QPTMDVL--------------SLLDQQI------KAPAVARLNSLGPNASTESEMASYLHRKCS- 637
            ..:.::|              .|.|..|      :...|.|:..:.|....::...|....|.|
Zfish   714 VCSKNILVARDGLDGEGGPFIKLSDPGIPITVLSREECVDRIPWIAPECVKDTANLSIAADKWSF 778

  Fly   638 GTP------------------------------STPSATEVEAAKLR------------FF---- 656
            ||.                              :||...|:  |||.            ||
Zfish   779 GTTLWEICYNGEIPLKDKKLTEKERFYAAQCQLATPDCDEL--AKLMTHCMTYDPRQRLFFRAIV 841

  Fly   657 ------------IEP-----------EKLVLD--REIGHGEFGSVHSGWLLRKSGAGEESRLEVA 696
                        |:|           ||..|.  |::|.|.||.|.   |.|....|:.:...||
Zfish   842 RDIVMVEKQNPSIQPVPMLEVDPTVFEKRFLKKIRDLGEGHFGKVE---LCRYDPRGDRTGELVA 903

  Fly   697 IKMLSDEHSNKQ--EFLREASVMMRLEHKCIVRLIGIAK---GEMLMMVQELAPLGSMLQYILDH 756
            :|.|..|:..:|  ...||..::..|.|:.||:..||..   |..:.::.|..|.||:.:|:..:
Zfish   904 VKSLKPENREEQSNNLWREIHILRELYHENIVKYKGICNEEGGRSIKLIMEFLPAGSLKEYLPRN 968

  Fly   757 GHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEY 821
            ...|.....|. ::.||..||.||.|::::||||||||:|:......||.|||:::|::.....|
Zfish   969 KAHINLKTLLN-YSVQICQGMDYLGSRNYIHRDLAARNVLVENEGTVKIGDFGLTKSIKDNEGYY 1032

  Fly   822 QFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFS--------------LGAPPYGEIS 872
            ........|:.|||||......|..||||||||||::|:.:              |..|.:|:::
Zfish  1033 TVKDDLDSPVFWYAPECLIHCKFYRASDVWSFGVTMYELLTYCDASCSPMSVFLKLIGPTHGQMT 1097

  Fly   873 NVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFFARDPDYQ 928
            ....:|:::.|:|||:|:.|...:|.:|:.||:..|:.|..|..|...|.:..|.|
Zfish  1098 VTRLVKVLEEGKRLPRPDDCSEQLYNLMRRCWEATPEKRINFKSLIANFQQMLDNQ 1153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	9/45 (20%)
		Ank_2	<112..184	CDD:289560	19/91 (21%)
		ANK	117..241	CDD:238125	33/173 (19%)
		ANK repeat	124..151	CDD:293786	9/32 (28%)
		ANK repeat	153..184	CDD:293786	6/34 (18%)
		Ank_2	158..247	CDD:289560	23/122 (19%)
		ANK repeat	186..217	CDD:293786	7/30 (23%)
		ANK repeat	220..245	CDD:293786	7/31 (23%)
		Ank_4	224..274	CDD:290365	11/68 (16%)
		SH2_Cterm_shark_like	287..395	CDD:198211	25/168 (15%)
		TyrKc	662..921	CDD:197581	91/279 (33%)
		PTKc_Syk_like	666..926	CDD:270650	91/278 (33%)
jak1	NP_571148.1	B41	35..276	CDD:214604	40/196 (20%)
		FERM_C_JAK1	280..422	CDD:275412	20/143 (14%)
		SH2_Jak1	422..523	CDD:198241	22/123 (18%)
		PTK_Jak1_rpt1	580..845	CDD:270662	52/277 (19%)
		Pkinase_Tyr	580..844	CDD:285015	52/276 (19%)
		PKc_like	867..1150	CDD:304357	94/286 (33%)
		Pkinase_Tyr	872..1146	CDD:285015	91/277 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810