DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shark and Srms

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001011961.1 Gene:Srms / 296472 RGDID:1306602 Length:507 Species:Rattus norvegicus


Alignment Length:416 Identity:122/416 - (29%)
Similarity:187/416 - (44%) Gaps:61/416 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   543 GEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQI 607
            ||.....|.:.|....|.|:....:|..|  |.||        ..|..||...| ....||....
  Rat   100 GEYIFAQRLSGPPSTGLVPVTYLAKATPE--TPSD--------QPWYFNGISRT-QAQQLLLSPA 153

  Fly   608 KAPAVARL----NSLGPNASTESEMASYLHRKCSGTPS--------------------------- 641
            .||....:    :|:|..:.:....|...|.:....||                           
  Rat   154 NAPGAFLIRPSESSIGGYSLSVRAQAKVCHYRICMAPSGGLYLQEGRLFPSLDALLAYYKTNWKL 218

  Fly   642 ------TPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKM 699
                  .|...::..|:..:.....:.||.|::|.|.||.|..| ||         ....||:|:
  Rat   219 IQNPLLQPCVPQMPLAQDEWERPRSEFVLRRKLGEGFFGEVWEGLWL---------GSTPVAVKV 274

  Fly   700 LSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAK-GEMLMMVQELAPLGSMLQYILDHGHEITAN 763
            :........:..:|...:..|.|:.::||..|.. ||.:.:|.||...|::..|:.....:..:.
  Rat   275 IKSADMKLADLTKEIEALKSLRHERLIRLHAICSLGEPVYIVTELMGKGNLQVYLGSPEGKALSL 339

  Fly   764 AELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGR 828
            ..|..:|.|:|.||.|||.:..|||||||||:|:......|::|||::|.|:  ...|..:.|.:
  Rat   340 PHLLGFACQVAEGMSYLEERRVVHRDLAARNVLVGDDLTCKVADFGLARLLK--DDVYSPSSGSK 402

  Fly   829 WPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCP 893
            .|::|.|||:.|..:||..|||||||:.::|:|:.|..||..::|.:.::.:..|.|||:|.:||
  Rat   403 IPVKWTAPEAANYRVFSQKSDVWSFGILLYEVFTYGQCPYEGMTNHETLQQISRGYRLPRPAVCP 467

  Fly   894 AYIYAVMQSCWKERPKDRPTFVYLTE 919
            |.:|.:|..|||..|::||||..|.|
  Rat   468 AEVYMLMVECWKGSPEERPTFATLRE 493

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211
TyrKc 662..921 CDD:197581 95/260 (37%)
PTKc_Syk_like 666..926 CDD:270650 93/256 (36%)
SrmsNP_001011961.1 SH3 70..124 CDD:302595 6/23 (26%)
SH2 134..212 CDD:301589 14/78 (18%)
PTKc_Srm_Brk 238..498 CDD:133248 95/267 (36%)
Pkinase_Tyr 245..495 CDD:285015 95/260 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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