DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and Hck

DIOPT Version :10

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_037317.2 Gene:Hck / 25734 RGDID:2785 Length:524 Species:Rattus norvegicus


Alignment Length:518 Identity:140/518 - (27%)
Similarity:231/518 - (44%) Gaps:133/518 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   527 STFNADGVTGS----GAAAAGEVYNVPRNNTPIEI------DLPP-IAQKTE-----AEVEY--- 572
            |.|..:|...|    .|...|.|| ||...:|.::      .||| :.:.:|     |..:|   
  Rat    27 SRFLREGSKASKIEPNANQKGPVY-VPDPTSPKKLGPNSINSLPPGVVEGSEDTIVVALYDYEAI 90

  Fly   573 ------FTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTE------ 625
                  |.|.|..:..|.:|:|     .....:.:..:..|.:..|||:|||    .||      
  Rat    91 HREDLSFQKGDQMVVLEESGEW-----WKARSLATKKEGYIPSNYVARVNSL----ETEEWFFKG 146

  Fly   626 --------------SEMASYLHRKCSGTPSTPSAT----------EVEAAKLR------FFIEP- 659
                          :.:.|::.|....|..:.|.:          .|:..|:|      |:|.| 
  Rat   147 ISRKDAERHLLAPGNMLGSFMIRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISPR 211

  Fly   660 ----------------------------------------------EKLVLDREIGHGEFGSVHS 678
                                                          |.|.:::::|.|:||.|  
  Rat   212 STFSSLQELVVHYKKGKDGLCQKLSVPCVSPKPQKPWEKDAWEIPRESLQMEKKLGAGQFGEV-- 274

  Fly   679 GWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQEL 743
             |:     |......:||:|.:.....:.:.||.||::|..|:|..:|:|..:...|.:.:|.|.
  Rat   275 -WM-----ATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLHAVVSQEPIFIVTEF 333

  Fly   744 APLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDF 808
            ...||:|.::...........:|..:::||:.||.::|.::::||||.|.|||::|....||:||
  Rat   334 MAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADF 398

  Fly   809 GMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISN 873
            |::|.:.  ..||...:|.::||:|.|||:.|.|.|:..|||||||:.:.|:.:.|..||..:||
  Rat   399 GLARIIE--DNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSN 461

  Fly   874 VDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVY----LTEFF-ARDPDYQNLP 931
            .:.|:.::.|.|:|:|:.||..:|::|..|||.||::||||.|    |.:|: |.:..||..|
  Rat   462 PEVIRALEHGYRMPRPDNCPEELYSIMIRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
SH2_Cterm_shark_like 287..395 CDD:198211
PTKc_Syk_like 666..926 CDD:270650 93/264 (35%)
HckNP_037317.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..71 10/36 (28%)
SH3 80..135 CDD:473055 12/59 (20%)
SH2_Src_HCK 138..241 CDD:198226 12/102 (12%)
Protein Kinases, catalytic domain 252..522 CDD:473864 96/279 (34%)
Blue background indicates that the domain is not in the aligned region.

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