DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shark and Hck

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_037317.2 Gene:Hck / 25734 RGDID:2785 Length:524 Species:Rattus norvegicus


Alignment Length:518 Identity:140/518 - (27%)
Similarity:231/518 - (44%) Gaps:133/518 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   527 STFNADGVTGS----GAAAAGEVYNVPRNNTPIEI------DLPP-IAQKTE-----AEVEY--- 572
            |.|..:|...|    .|...|.|| ||...:|.::      .||| :.:.:|     |..:|   
  Rat    27 SRFLREGSKASKIEPNANQKGPVY-VPDPTSPKKLGPNSINSLPPGVVEGSEDTIVVALYDYEAI 90

  Fly   573 ------FTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTE------ 625
                  |.|.|..:..|.:|:|     .....:.:..:..|.:..|||:|||    .||      
  Rat    91 HREDLSFQKGDQMVVLEESGEW-----WKARSLATKKEGYIPSNYVARVNSL----ETEEWFFKG 146

  Fly   626 --------------SEMASYLHRKCSGTPSTPSAT----------EVEAAKLR------FFIEP- 659
                          :.:.|::.|....|..:.|.:          .|:..|:|      |:|.| 
  Rat   147 ISRKDAERHLLAPGNMLGSFMIRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISPR 211

  Fly   660 ----------------------------------------------EKLVLDREIGHGEFGSVHS 678
                                                          |.|.:::::|.|:||.|  
  Rat   212 STFSSLQELVVHYKKGKDGLCQKLSVPCVSPKPQKPWEKDAWEIPRESLQMEKKLGAGQFGEV-- 274

  Fly   679 GWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQEL 743
             |:     |......:||:|.:.....:.:.||.||::|..|:|..:|:|..:...|.:.:|.|.
  Rat   275 -WM-----ATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLHAVVSQEPIFIVTEF 333

  Fly   744 APLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDF 808
            ...||:|.::...........:|..:::||:.||.::|.::::||||.|.|||::|....||:||
  Rat   334 MAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADF 398

  Fly   809 GMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISN 873
            |::|.:.  ..||...:|.::||:|.|||:.|.|.|:..|||||||:.:.|:.:.|..||..:||
  Rat   399 GLARIIE--DNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSN 461

  Fly   874 VDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVY----LTEFF-ARDPDYQNLP 931
            .:.|:.::.|.|:|:|:.||..:|::|..|||.||::||||.|    |.:|: |.:..||..|
  Rat   462 PEVIRALEHGYRMPRPDNCPEELYSIMIRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211
TyrKc 662..921 CDD:197581 92/262 (35%)
PTKc_Syk_like 666..926 CDD:270650 93/264 (35%)
HckNP_037317.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 35..71 10/36 (28%)
SH3 80..135 CDD:302595 12/59 (20%)
SH2_Src_HCK 138..241 CDD:198226 12/102 (12%)
PKc_like 252..522 CDD:304357 96/279 (34%)
Pkinase_Tyr 260..509 CDD:285015 91/258 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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