DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shark and FYN

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001357458.1 Gene:FYN / 2534 HGNCID:4037 Length:537 Species:Homo sapiens


Alignment Length:564 Identity:151/564 - (26%)
Similarity:234/564 - (41%) Gaps:129/564 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   431 TPPTPVSPHSHHQHPHVPALTITKKKQKE----------------NSSSMFNTLRLTSPK----- 474
            |.|||         .|.|:..:|......                ||||...|||.....     
Human    32 TDPTP---------QHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLF 87

  Fly   475 KALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGA 539
            .||:|..                      |.||.:|.........:..|:|...:.|..:|    
Human    88 VALYDYE----------------------ARTEDDLSFHKGEKFQILNSSEGDWWEARSLT---- 126

  Fly   540 AAAGEVYNVPRNN-TPIEIDLPPIAQKTEAEVEYFTK---SDVAIERE-------------RAGQ 587
              .||...:|.|. .|::        ..:||..||.|   .|.  ||:             |..:
Human   127 --TGETGYIPSNYVAPVD--------SIQAEEWYFGKLGRKDA--ERQLLSFGNPRGTFLIRESE 179

  Fly   588 WIGNGYQPTMDVLSLLD------QQIKAPAVARLNSLGPNASTES------EMASYLHRKCSGT- 639
            .....|.     ||:.|      ..:|...:.:|::.|...:|.:      ::..:...:.:|. 
Human   180 TTKGAYS-----LSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLC 239

  Fly   640 --------PSTPSATEVEA-AKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLE 694
                    ...|..|::.. .|..:.|..|.|.|.:.:|:|:||.|..| |         ....:
Human   240 CRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTW---------NGNTK 295

  Fly   695 VAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHE 759
            ||||.|.....:.:.||.||.:|.:|:|..:|:|..:...|.:.:|.|....||:|.::.|....
Human   296 VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR 360

  Fly   760 ITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFT 824
            ......|...|:|:|.||.|:|..:::||||.:.|||:......||:|||::|.:.  ..||...
Human   361 ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIE--DNEYTAR 423

  Fly   825 QGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQP 889
            ||.::||:|.|||:...|.|:..|||||||:.:.|:.:.|..||..::|.:.::.|:.|.|:|.|
Human   424 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCP 488

  Fly   890 NLCPAYIYAVMQSCWKERPKDRPTFVYLTEFF-----ARDPDYQ 928
            ..||..::.:|..|||:.|::||||.||..|.     |.:|.||
Human   489 QDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQ 532

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211
TyrKc 662..921 CDD:197581 93/259 (36%)
PTKc_Syk_like 666..926 CDD:270650 93/265 (35%)
FYNNP_001357458.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 14..35 1/2 (50%)
SH3_Fyn_Yrk 85..140 CDD:212939 15/82 (18%)
SH2_Src_Fyn_isoform_a_like 145..245 CDD:198281 18/106 (17%)
PTKc_Fyn 261..534 CDD:270655 101/283 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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