Protein Alignment Shark and Fyn

DIOPT Version :9

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: XP_006256584.1
• Gene: Fyn / 25150
• RGDID: 2641
• Length: 575
• Species: Rattus norvegicus
• Alignment Length: 564
• Identity: 151/564 - (26%)
• Similarity: 234/564 - (41%)
• Gaps: 129/564 - (22%)

  Fly   431 TPPTPVSPHSHHQHPHVPALTITKKKQKE----------------NSSSMFNTLRLTSPK----- 474
            |.|||         .|.|:..:|......                ||||...|||.....
  Rat    70 TDPTP---------QHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLF 125

  Fly   475 KALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGA 539
            .||:|..                      |.||.:|.........:..|:|...:.|..:|
  Rat   126 VALYDYE----------------------ARTEDDLSFHKGEKFQILNSSEGDWWEARSLT---- 164

  Fly   540 AAAGEVYNVPRNN-TPIEIDLPPIAQKTEAEVEYFTK---SDVAIERE-------------RAGQ 587
              .||...:|.|. .|::        ..:||..||.|   .|.  ||:             |..:
  Rat   165 --TGETGYIPSNYVAPVD--------SIQAEEWYFGKLGRKDA--ERQLLSFGNPRGTFLIRESE 217

  Fly   588 WIGNGYQPTMDVLSLLD------QQIKAPAVARLNSLGPNASTES------EMASYLHRKCSGT- 639
            .....|.     ||:.|      ..:|...:.:|::.|...:|.:      ::..:...:.:|.
  Rat   218 TTKGAYS-----LSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLC 277

  Fly   640 --------PSTPSATEVEA-AKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLE 694
                    ...|..|::.. .|..:.|..|.|.|.:.:|:|:||.|..| |         ....:
  Rat   278 CRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTW---------NGNTK 333

  Fly   695 VAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHE 759
            ||||.|.....:.:.||.||.:|.:|:|..:|:|..:...|.:.:|.|....||:|.::.|....
  Rat   334 VAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR 398

  Fly   760 ITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFT 824
            ......|...|:|:|.||.|:|..:::||||.:.|||:......||:|||::|.:.  ..||...
  Rat   399 ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIE--DNEYTAR 461

  Fly   825 QGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQP 889
            ||.::||:|.|||:...|.|:..|||||||:.:.|:.:.|..||..::|.:.::.|:.|.|:|.|
  Rat   462 QGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCP 526

  Fly   890 NLCPAYIYAVMQSCWKERPKDRPTFVYLTEFF-----ARDPDYQ 928
            ..||..::.:|..|||:.|::||||.||..|.     |.:|.||
  Rat   527 QDCPISLHELMIHCWKKDPEERPTFEYLQGFLEDYFTATEPQYQ 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560
		ANK	117..241	CDD:238125
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		Ank_2	158..247	CDD:289560
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		Ank_4	224..274	CDD:290365
		SH2_Cterm_shark_like	287..395	CDD:198211
		TyrKc	662..921	CDD:197581	93/259 (36%)
		PTKc_Syk_like	666..926	CDD:270650	93/265 (35%)
Fyn	XP_006256584.1	SH3_Fyn_Yrk	123..178	CDD:212939	15/82 (18%)
		SH2_Src_Fyn_isoform_a_like	183..283	CDD:198281	18/106 (17%)
		PTKc_Fyn	299..572	CDD:270655	101/283 (36%)
		Pkinase_Tyr	309..558	CDD:285015	93/259 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810