Protein Alignment Shark and FRK

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_002022.1
• Gene: FRK / 2444
• HGNCID: 3955
• Length: 505
• Species: Homo sapiens
• Alignment Length: 1225
• Identity: 212/1225 - (17%)
• Similarity: 372/1225 - (30%)
• Gaps: 458/1225 - (37%)

  Fly   763 KPLSEIV---PVKRWGE-----KMAPDGKIEWRVPDEGARAVCERIMHRYLPGLLAKLEQHSAG- 818
            ||:..:|   .:.||||     |.:|        |.|......|.|..:.|..|...|..|:..
Human   579 KPIELLVCFSALVRWGESGALTKESP--------PVEPGLLTAEAITWKSLKPLSVVLRIHTYAT 635

  Fly   819 ---------------------------------------EVTLPREE------LHRSVMMVQALI 838
                                                   :|.||..|      ..:|||:::|:
Human   636 KASMVRLPVGRHMLLFNAYSPVGHAIHVCSMTTFVIGDEDVVLPNFEPESYRFTEQSVMIMKAI- 699

  Fly   839 RCYNFLPNWTDEEPIKLFETCVDLRELQLNVTLGFEGLEI-----------RMPGGENVRKA--- 889
              .|.:.|:.|..  ||.....||:.....:.|..:.|.:           |:.....|.|.
Human   700 --GNVIANFKDRG--KLPAALRDLQAAHYPIPLNNKELTLQHFRVFHISLWRLMKKSQVAKPPLN 760

  Fly   890 ---IIRTIARLQDRLLEVSED----DTQTLKAIVTLYEK----------VLLRKHPNGSYEMQLK 937
               ..|.:....|.|...|||    :...||..:.:.||          |.::....|:|...|.
Human   761 FKFAFRAMVLDTDLLDSFSEDASLAEWVDLKYSMPVNEKEYSPEEIAAAVKIQSMWKGNYVRLLM 825

  Fly   938 TFNSTKRFQTYQLTRCKRDVRAVV----------VTRVIIQQDCRDEMSLPLFSATHLEVMKKLL 992
            ...:.:..:...:....:.:.||:          :.|::.:..|:...|.|.:...  |......
Human   826 KARTPETKENISVADTLQKIWAVLEMNLEQYALSLLRLMFKSKCKSMESYPCYQDE--ETKLAFA 888

  Fly   993 ELSVSY----------------------------YSTVRIEAQAKLH----DMLYLFPYAY---- 1021
            :.:|:|                            |:|::|   ..||    |.|...|..:
Human   889 DHTVNYTDQPPNSWFIVFRETFLVPQDIILLPKVYTTLQI---CMLHVINNDTLEQVPKVFQKVV 950

  Fly  1022 PLLTDR-------IVECLQLDANTNHERFKGILCLLFIKRRGRLI-SQNNWEYLARVWPALLRSK 1078
            |.|..:       :.|....|:..:..|:|           .||| |.|...:|||..|.   |.
Human   951 PYLYSKNKKGYTFVAEAYTGDSFVSGSRWK-----------LRLIGSYNPLPFLARDTPC---ST 1001

  Fly  1079 LSVKPSIVKLVDGLKKMIDGQSPTYLLEVDIGEKVVERALALRTRVDELDLAPGQAARARENKRN 1143
            .::|......:...||::.    .|.::|.:.:.:                    ..:.|.:|.:
Human  1002 FTIKEIRDYYIPNDKKILF----RYSIKVTMAQSI--------------------TIQVRTSKPD 1042

  Fly  1144 MELFQQLIAD---IVQTV-ETSKLHLRYHYLASVMLINLCHPYAEHPPSVTRLTVHHLIHDSVTE 1204
            ..:..|::..   |:.|| :...|...:::|.:                               |
Human  1043 AFIKLQVLESEEIIMSTVGKGQALIPAFYFLGN-------------------------------E 1076

  Fly  1205 RKLAIQLLLGIFRQQKRPQKKCVMNPLEIVARLAGQDGGSVPPNPGSNVAPGYRDDNM------W 1263
            :.|:.|....:......|:|:    |..:..:.|||        ||.....|.....|      .
Human  1077 KALSSQSSKQVLLTHTLPKKE----PEVLTKKKAGQ--------PGQKSFKGRTGGGMTETGMPL 1129

  Fly  1264 LQYDVARVPKSQAEWDEPR--YMYTVEGCF----GWTQGFKMYAPSAEQPKLDRTVDELSEHERT 1322
            |:.:|..||..:.....|:  |.|.:: |.    .|                     .|:|.:.|
Human  1130 LEEEVMSVPTIEENSSTPQQCYKYIIQ-CLVLFNSW---------------------PLNETQLT 1172

  Fly  1323 IFEFFDQQENVDTLMRFWSLEEKKGRDEFSGSRMLMIKMLFKLFGDRLLDRFLCHMKRLIEDKAT 1387
            ..:.....|.:|                        ||               .|:::..|....
Human  1173 FVQALKDMEKID------------------------IK---------------AHVEKHEEPAPM 1198

  Fly  1388 ESNHRCAVEV------MTGIMRGAKHWPYEKTRSMYERLVPLIRLGMQNVTVDTDMYWGMCFATA 1446
            .|....||..      |....|..|....||.:|..|:..|  |...|.:.|.|        |..
Human  1199 GSPDSHAVSEGQKSVGMPKTTRKGKERSAEKEKSAREKQTP--RFEPQQMQVPT--------AAH 1253

  Fly  1447 AQSMDPSKQHWLHEVLLEDPLQDANSFSDCNRLYCLQGAFNQHVWRMASVAHRLLDYLKPHLDHP 1511
            :|..||:|.:|...::.|                                          |.|..
Human  1254 SQQEDPNKPYWTLRLVSE------------------------------------------HTDSE 1276

  Fly  1512 FQSLR---ERLGNTLINIFEGDLRFEGYECRAISPQRSEMIAYVMPKLAILLQKDPEPPK----- 1568
            :..::   ||         ..::|..........|.|:  |.....:|..|.|...:||:
Human  1277 YVDVKKDTER---------ADEIRAMKQAWETTEPGRA--IKASQARLKYLTQFIKKPPETSAPA 1330

  Fly  1569 --PKVAAADEMQM------EVEGG-APDEDSEYV----------KAVRLFKTIAHWITYTIHRYS 1614
              |:..:..:.|:      |..|| ..|.|::.:          |..:|.||:: .::......|
Human  1331 TSPEALSVTQSQIKSSEEGEQAGGTGKDADTKELPPTAAGSMLWKKWQLTKTLS-VLSKATSSES 1394

  Fly  1615 NGNEKEYFELLPIACR------LERSEQDQELSEICTLLLAFISQALTLPNCMDVALAKIDEVSK 1673
            :..|:...:.:|:..:      ||.|.|....:      |.|:.....:....|.|:.:.||:||
Human  1395 SPKEEPPRKEIPVVVQSRSPTILETSPQQIRKA------LEFLDFNHYVRKTADEAVLQTDELSK 1453

  Fly  1674 MSFWSARRAVIDVLQVQVF--YNMTIILSR---PEWKAKVQEIVLRL---LEDSVVEVREKAAEV 1730
                  .:|:....::..|  |...|:..|   .|.:.|:::.||.:   :.|||.|.|:|..::
Human  1454 ------HQAMQKAEEIHQFRQYRARILSIRDIDQEERVKLKDEVLDMYGEMRDSVDEARQKIFDI 1512

  Fly  1731 LCGLVHCSFLTATEELLELFKRKCRTKIIRSKRIRVEAASCSSEVARNENAEANA 1785
                                :.:.|.|::.::|:|:||.:......:.|..:..|
Human  1513 --------------------REEYRNKLLEAERLRMEALAAQEAAVKLEAEKKTA 1547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		ANKYR	<94..317	CDD:440430
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		SH2_Cterm_shark_like	287..395	CDD:198211
		PTKc_Syk_like	666..926	CDD:270650	48/247 (19%)
FRK	NP_002022.1	SH3_Src_like	47..104	CDD:212779
		SH2_Src_Frk	112..207	CDD:199831
		PTKc_Frk_like	225..494	CDD:270653