DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and FGR

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001036194.1 Gene:FGR / 2268 HGNCID:3697 Length:529 Species:Homo sapiens


Alignment Length:574 Identity:157/574 - (27%)
Similarity:248/574 - (43%) Gaps:132/574 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   402 PVPPQPKPEVPSFATIPR-SNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMF 465
            |.|.:.:| ..|||.||. ||...:|.:|.               .:.:.||      ...|.:.
Human    36 PDPTKARP-ASSFAHIPNYSNFSSQAINPG---------------FLDSGTI------RGVSGIG 78

  Fly   466 NTLRLTSPKKALFDMNSLRKNK---SKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFS 527
            .||.:     ||:|..:..::.   :||::..       .|..||.:...|    :|||      
Human    79 VTLFI-----ALYDYEARTEDDLTFTKGEKFH-------ILNNTEGDWWEA----RSLS------ 121

  Fly   528 TFNADGVTGSGAAAAGEVYNVPRNN-TPIEIDLPPIAQKTEAEVEYFTKSDVAIERERA------ 585
                .|.||.          :|.|. .|::        ..:||..||.|    |.|:.|      
Human   122 ----SGKTGC----------IPSNYVAPVD--------SIQAEEWYFGK----IGRKDAERQLLS 160

  Fly   586 -----GQWIGNGYQPTMDVLSL----LDQ----QIKAPAVARLNSLGPNASTESE---------- 627
                 |.::....:.|....||    .||    .:|...:.:|:..|...:|..:          
Human   161 PGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGGYYITTRVQFNSVQELVQH 225

  Fly   628 -------MASYLHRKCS-GTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRK 684
                   :.:.|...|: ..|.|     :..||..:.|....:.|:|.:|.|.||.|   ||...
Human   226 YMEVNDGLCNLLIAPCTIMKPQT-----LGLAKDAWEISRSSITLERRLGTGCFGDV---WLGTW 282

  Fly   685 SGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSM 749
            :|:     .:||:|.|.....:.:.||.||.||..|.|..:|:|..:...|.:.:|.|....||:
Human   283 NGS-----TKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVVSEEPIYIVTEFMCHGSL 342

  Fly   750 LQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSL 814
            |.::.:...:.....:|...|:|:|.||.|:|..:::||||.|.|||:..|...||:|||::|.:
Human   343 LDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGERLACKIADFGLARLI 407

  Fly   815 RPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKL 879
            :  ..||...||.::||:|.|||:...|.|:..|||||||:.:.|:.:.|..||..::..:.::.
Human   408 K--DDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQ 470

  Fly   880 VDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFF-----ARDPDYQ 928
            |:.|..:|.|..|||.:|..|:..|:..|::||||.||..|.     :.:|.||
Human   471 VEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTFEYLQSFLEDYFTSAEPQYQ 524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211
TyrKc 662..921 CDD:197581 93/258 (36%)
PTKc_Syk_like 666..926 CDD:270650 93/264 (35%)
FGRNP_001036194.1 SH3 80..137 CDD:327375 20/92 (22%)
SH2_Src_Fgr 140..240 CDD:198230 19/103 (18%)
PKc_like 267..514 CDD:328722 93/256 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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