DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and Yes1

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001192061.1 Gene:Yes1 / 22612 MGIID:99147 Length:541 Species:Mus musculus


Alignment Length:571 Identity:166/571 - (29%)
Similarity:250/571 - (43%) Gaps:115/571 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   428 SPA---TPPT---PVSPHSHH---QHPHVPALTITKKKQKENSSSMFNTLRLT----SPKKALFD 479
            |||   ||..   ||||.:.|   :|..|...:.||     .:|..||:|.:|    |.....| 
Mouse    11 SPAIKYTPENLTEPVSPSASHYGVEHATVAPTSSTK-----GASVNFNSLSMTPFGGSSGVTPF- 69

  Fly   480 MNSLRKNKSKGKRSDSESSVSGS----LAGTEQELQA----AAPMLKSLSF----------STEF 526
                      |..|.|.|.||.|    |.|......|    .|...:.|||          :||.
Mouse    70 ----------GGASSSFSVVSSSYPTGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEG 124

  Fly   527 STFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQWIGN 591
            ..:.|..:      |.|:...:|.|..     :|  |...:||..||.|    :.|:.|.:.:.|
Mouse   125 DWWEARSI------ATGKSGYIPSNYV-----VP--ADSIQAEEWYFGK----MGRKDAERLLLN 172

  Fly   592 -GYQPTMDV------------LSLLD------QQIKAPAVARLNSLGPNASTESEMAS------- 630
             |.|..:.:            ||:.|      ..:|...:.:|::.|...:|.::..:       
Mouse   173 PGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKH 237

  Fly   631 -------YLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGA 687
                   ..|:..:..|:....|: ..||..:.|..|.|.|:.::|.|.||.|..| |       
Mouse   238 YTEHADGLCHKLTTVCPTVKPQTQ-GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTW------- 294

  Fly   688 GEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQY 752
              ....:||||.|.......:.||:||.:|.:|.|..:|.|..:...|.:.:|.|....||:|.:
Mouse   295 --NGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDF 357

  Fly   753 ILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPG 817
            :.:...:.....:|...|:|||.||.|:|..:::||||.|.|||:......||:|||::|.:.  
Mouse   358 LKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLARLIE-- 420

  Fly   818 STEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDS 882
            ..||...||.::||:|.|||:...|.|:..|||||||:...|:.:.|..||..:.|.:.::.|:.
Mouse   421 DNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVER 485

  Fly   883 GERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFF-----ARDPDYQ 928
            |.|:|.|..||..::.:|..|||:.|.:||||.|:..|.     |.:|.||
Mouse   486 GYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQ 536

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211
TyrKc 662..921 CDD:197581 93/259 (36%)
PTKc_Syk_like 666..926 CDD:270650 93/265 (35%)
Yes1NP_001192061.1 SH3_Yes 92..149 CDD:212940 13/69 (19%)
SH2_Src_family 152..251 CDD:199827 18/102 (18%)
PTKc_Yes 262..540 CDD:270654 102/286 (36%)
Pkinase_Tyr 275..524 CDD:285015 93/259 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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