DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shark and Txk

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	XP_036020891.1	Gene:	Txk / 22165	MGIID:	102960	Length:	543	Species:	Mus musculus

Alignment Length:	824	Identity:	170/824 - (20%)
Similarity:	273/824 - (33%)	Gaps:	353/824 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 DAKNQD------GQTALHLAALHSDEDIL----------KHLLNAKVQVNSSDSFGCQPLHYAAR 196
            :.|||.      .:.|:.|::..|.:.:|          |..:..::.::..:....:   ::.|
Mouse    14 ELKNQGFCVWPASRVAMILSSYSSFQSVLCCCCCRCSVQKRQVRTQISLSREEELSEK---HSQR 75

  Fly   197 SKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSSGE------ 255
            .:| .|.:.:...|:|..|                     ||.......||||:....|
Mouse    76 QRP-WFAKLMGKTQSNRGG---------------------VQPSKRKPLPPLPQEPPDERIQVKA 118

  Fly   256 -FPFDLAKEAGQTAV---EEFLL----------------NYKLPPANTTRD---------QWYHG 291
             :.| |.:|.|..|:   ||:|:                |..|.|:|...:         :|||.
Mouse   119 LYDF-LPREPGNLALKRAEEYLILERCDPHWWKARDRFGNEGLIPSNYVTENRLANLEIYEWYHK 182

  Fly   292 TLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGL-VLTLL---CDQVVKNFRISQ 352
            .:||.:...:|::.|||           |.|:||.|....:..: |.|..   ....:|:::|.:
Mouse   183 NITRNQTERLLRQEAKE-----------GAFIVRDSRHLGSYTISVFTRARRHTQSSIKHYQIKK 236

  Fly   353 ADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFATI 417
            .|..|            .||.:...:|||..||.:....:.||...|:||:
Mouse   237 NDSGQ------------WYITERHLFPSVPELIQYHQYNAAGLISRLRYPI-------------- 275

  Fly   418 PRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMNS 482

Mouse   276 ----------------------------------------------------------------- 275

  Fly   483 LRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYN 547
                                                              |:.||...|..
Mouse   276 --------------------------------------------------GLLGSCLPATS---- 286

  Fly   548 VPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAV 612
                                                      |..|:
Mouse   287 ------------------------------------------GFSYE------------------ 291

  Fly   613 ARLNSLGPNASTESEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVH 677
                                                     ::.|:|.:|...:|||.|:||.||
Mouse   292 -----------------------------------------KWEIDPSELAFVKEIGSGQFGVVH 315

  Fly   678 SG-WLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIA-KGEMLMMV 740
            .| |         .:.:.||||.:::...::::|:.||.|||:|.|..:|:|.|:. :.:.|.:|
Mouse   316 LGEW---------RAHIPVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIV 371

  Fly   741 QELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKI 805
            .|....|.:|.|:.:...:: ..|.|......|..||.|||...::||||||||.|:::....||
Mouse   372 TEFMENGCLLDYLRERKGQL-QKALLLSMCQDICEGMAYLERSCYIHRDLAARNCLVSSACVVKI 435

  Fly   806 SDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGE 870
            |||||:|.:.  ..||..:.|.::|::|..||.|:...:|..||||||||.:||:|:.|..|:..
Mouse   436 SDFGMARYVL--DDEYISSSGAKFPVKWCPPEVFHFNKYSSKSDVWSFGVLMWEVFTEGKMPFEN 498

  Fly   871 ISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTF 914
            .||:..::.:..|.||.:|:|.|..||.||.|||.| ...:|.|
Mouse   499 KSNLQVVEAISQGFRLYRPHLAPMTIYRVMYSCWHE-TLQKPVF 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560	8/51 (16%)
		ANK	117..241	CDD:238125	16/108 (15%)
		ANK repeat	124..151	CDD:293786	0/2 (0%)
		ANK repeat	153..184	CDD:293786	5/46 (11%)
		Ank_2	158..247	CDD:289560	12/98 (12%)
		ANK repeat	186..217	CDD:293786	6/30 (20%)
		ANK repeat	220..245	CDD:293786	2/24 (8%)
		Ank_4	224..274	CDD:290365	14/59 (24%)
		SH2_Cterm_shark_like	287..395	CDD:198211	27/111 (24%)
		TyrKc	662..921	CDD:197581	97/255 (38%)
		PTKc_Syk_like	666..926	CDD:270650	96/251 (38%)
Txk	XP_036020891.1	SH3_TXK	114..168	CDD:212840	12/54 (22%)
		SH2_Tec_Txk	172..277	CDD:198261	32/256 (13%)
		PKc_like	295..543	CDD:419665	99/260 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810