DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shark and Syk

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001185906.1 Gene:Syk / 20963 MGIID:99515 Length:629 Species:Mus musculus


Alignment Length:934 Identity:224/934 - (23%)
Similarity:334/934 - (35%) Gaps:359/934 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 MKWYHGNLSREAADELLKQ-GYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRH-------G 64
            :.::.||::||.|::.|.| |..||.:|:|:|....|.|.||:....:..||.:.|.       .
Mouse    12 LTYFFGNITREEAEDYLVQGGMTDGLYLLRQSRNYLGGFALSVAHNRKAHHYTIERELNGTYAIS 76

  Fly    65 GEDAFFSIDDKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNLLHRATS 129
            |..|..|..|            |..|:.|..:||...|..|..|  ||                 
Mouse    77 GGRAHASPAD------------LCHYHSQEPDGLICLLKKPFNR--PP----------------- 110

  Fly   130 KNESKVVFELLKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSFGCQPLHYA 194
                                                                     |.||....
Mouse   111 ---------------------------------------------------------GVQPKTGP 118

  Fly   195 ARSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSSGEFPFD 259
            ......:.||..:....|:||                   :|:::.::::.|            .
Mouse   119 FEDLKENLIREYVKQTWNLQG-------------------QALEQAIISQKP------------Q 152

  Fly   260 LAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLV 324
            |.|....||.|      |:|        |:||.::|:|:...:...:|          |:|.||:
Mouse   153 LEKLIATTAHE------KMP--------WFHGNISRDESEQTVLIGSK----------TNGKFLI 193

  Fly   325 RYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFM 389
            |..::  :....|.||.:..|.::||   |..:.|......|.||     ...|..|||      
Mouse   194 RARDN--SGSYALCLLHEGKVLHYRI---DRDKTGKLSIPEGKKF-----DTLWQLVEH------ 242

  Fly   390 RFSYGLPVSLKYPVPPQPKPE-VPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTIT 453
             :||              ||: :....|:|...:..:...|.:|         :.||        
Mouse   243 -YSY--------------KPDGLLRVLTVPCQKIGAQMGHPGSP---------NAHP-------- 275

  Fly   454 KKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLK 518
                                                         |:.|..|       ....:|
Mouse   276 ---------------------------------------------VTWSPGG-------IISRIK 288

  Fly   519 SLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERE 583
            |.||..                        |.:..|    .||...:.|:.|.:           
Mouse   289 SYSFPK------------------------PGHKKP----APPQGSRPESTVSF----------- 314

  Fly   584 RAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSATEV 648
                   |.|:||.                  ...||:...:.|             :.|..|||
Mouse   315 -------NPYEPTG------------------GPWGPDRGLQRE-------------ALPMDTEV 341

  Fly   649 ------EAAKLRFFIEPEKLVLDR--------EIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKM 699
                  :..::|    |:::.|||        |:|.|.||:|..|:...|...     ..||:|:
Mouse   342 YESPYADPEEIR----PKEVYLDRSLLTLEDNELGSGNFGTVKKGYYQMKKVV-----KTVAVKI 397

  Fly   700 LSDEHSN---KQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEIT 761
            |.:|.::   |.|.|.||:||.:|::..|||:|||.:.|..|:|.|:|.||.:.:|:..:.|...
Mouse   398 LKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHIKD 462

  Fly   762 AN-AELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQ 825
            .| .||   ..|::.||.|||..:||||||||||:||..:|.|||||||:|::||.....|:...
Mouse   463 KNIIEL---VHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQT 524

  Fly   826 GGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPN 890
            .|:||::|||||..|...||..||||||||.:||.||.|..||..:...:...:::.|||:..|.
Mouse   525 HGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPA 589

  Fly   891 LCPAYIYAVMQSCWKERPKDRPTF 914
            .||..:|.:|..||....::||.|
Mouse   590 GCPREMYDLMNLCWTYDVENRPGF 613

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210 25/90 (28%)
Ank_2 <112..184 CDD:289560 1/71 (1%)
ANK 117..241 CDD:238125 9/123 (7%)
ANK repeat 124..151 CDD:293786 0/26 (0%)
ANK repeat 153..184 CDD:293786 0/30 (0%)
Ank_2 158..247 CDD:289560 9/88 (10%)
ANK repeat 186..217 CDD:293786 8/30 (27%)
ANK repeat 220..245 CDD:293786 1/24 (4%)
Ank_4 224..274 CDD:290365 7/49 (14%)
SH2_Cterm_shark_like 287..395 CDD:198211 28/107 (26%)
TyrKc 662..921 CDD:197581 111/265 (42%)
PTKc_Syk_like 666..926 CDD:270650 109/261 (42%)
SykNP_001185906.1 SH2_N-SH2_Zap70_Syk_like 12..115 CDD:198191 36/190 (19%)
Interdomain A 107..166 19/171 (11%)
SH2_C-SH2_Syk_like 163..261 CDD:198264 35/152 (23%)
Interdomain B 259..364 33/254 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 293..328 12/98 (12%)
PTKc_Syk 370..625 CDD:133247 108/252 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 214 1.000 Domainoid score I2721
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 296 1.000 Inparanoid score I2718
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D345546at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_105357
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2868
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
76.830

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