Protein Alignment Shark and R151.1

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_001299880.1
• Gene: R151.1 / 187907
• WormBaseID: WBGene00020106
• Length: 696
• Species: Caenorhabditis elegans
• Alignment Length: 875
• Identity: 200/875 - (22%)
• Similarity: 302/875 - (34%)
• Gaps: 305/875 - (34%)

  Fly   116 RSHGVTNLLHRATSKNESKVVFELLKCGYRNFDAKNQDGQTALHLAALHSDE------------D 168
            ||..|.:..|..||:.....   |.||..|    ..:|.....||.|:....            .
 Worm    26 RSDCVESCSHLDTSQEFGDC---LAKCSKR----PRKDNLGDSHLFAMPPTNVEIETKVIMDGGK 83

  Fly   169 ILKHLLNAKVQ---------------VNSSDSFGCQPLHYAARSKPASFIRTLISAQANVQGRNI 218
            ||:..:|.|..               |||:    ||. |:     |..|..:::..:.::...:.
 Worm    84 ILETTINWKADEKDTRREGFYIRYTAVNST----CQK-HF-----PGYFTSSILPDERSLTIPSA 138

  Fly   219 DNGYVPL--HEAAKHGNLEAVQELLLAEAPPLPRTSSGEF------------------PFDLAKE 263
            .||:..:  |..:.|         |...|.|.|.......                  |.|:|..
 Worm   139 FNGHALVIDHSCSYH---------LQIRAKPYPPGDDKYIIERRHTVPDCIDKYCSCRPGDVAAI 194

  Fly   264 AGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSE 328
            ...:...|:.||:|.........|:|.....| .|:.::||...|     ||.:       .|:
 Worm   195 RDVSVDAEYRLNWKFDEMKGREYQFYVDVYER-IAMPLIKKKGSE-----PESE-------EYT- 245

  Fly   329 SPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSY 393
                               |||:.||.|:...|                  |.| ..||  .:.|
 Worm   246 -------------------FRIANADSYEISAK------------------SAE-TSAH--TYQY 270

  Fly   394 GLPVSLKYPVPPQPKPEVPSFAT------------IPRSNMKPKAASPATPPTPVSPHSHHQHPH 446
            .||    :...|..:.::..||.            |..:.....::|.....||:        |.
 Worm   271 QLP----FQFTPFQQYKISIFAVDDSFCHNQDVFHIFNTTNATFSSSEIPKTTPI--------PE 323

  Fly   447 VPALTITKKKQKENSSSMFNTLRLT---SPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQ 508
            :....|||......||.:...|.:.   ||...:..:..||:.|                    :
 Worm   324 ISGSAITKTTMLMESSILVIFLIVVACMSPICTMIVLLCLRRRK--------------------K 368

  Fly   509 ELQAAAPML--KSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVE 571
            |::.....|  :|||.|                           .::.||.::.
 Worm   369 EIKKRHHFLHRRSLSCS---------------------------RHSIIETNIL----------- 395

  Fly   572 YFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKC 636
                                 |:|..:|                     |..|..|
 Worm   396 ---------------------YRPPNEV---------------------NGGTTGE--------- 409

  Fly   637 SGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLS 701
                              :.|..:.:|:...||.|.||.|..|.|...:|    ..:.||:|.|.
 Worm   410 ------------------WLIRGQDIVVGAVIGEGAFGQVFKGILRGPNG----QVIPVAVKQLK 452

  Fly   702 ----DEHSNKQEFLREASVMMRL-EHKCIVRLIGIAKGEMLM-MVQELAPLGSMLQYILDHGHEI 760
                ||  .::||:||..:|..: :|..||.:.|....|.|. |:.|..|.|.:..|:.:...|.
 Worm   453 ANAIDE--EREEFVREIQMMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMRKEK 515

  Fly   761 TANA-----ELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTE 820
            .:::     |...:.:||||||.:|||...:||||||||||:......||||||||   |||  .
 Worm   516 DSDSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMS---RPG--V 575

  Fly   821 YQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGER 885
            |.....|..|:||.:||:.....:|:.||||:|||.:||:.:||..||..:::.|.:..:..|.|
 Worm   576 YIKMSKGVIPLRWLSPEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEGMR 640

  Fly   886 LPQPNLCPAYIYAVMQSCWKERPKDRPTFV 915
            |.||..|...:|.:|:|||..:.:|||:|:
 Worm   641 LEQPAKCSDDMYILMKSCWNLKAEDRPSFL 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		ANKYR	<94..317	CDD:440430	50/247 (20%)
		ANK repeat	124..151	CDD:293786	7/26 (27%)
		ANK repeat	153..184	CDD:293786	11/57 (19%)
		ANK repeat	186..217	CDD:293786	5/30 (17%)
		ANK repeat	220..245	CDD:293786	5/26 (19%)
		SH2_Cterm_shark_like	287..395	CDD:198211	22/107 (21%)
		PTKc_Syk_like	666..926	CDD:270650	100/261 (38%)
R151.1	NP_001299880.1	PTKc	422..677	CDD:270623	100/260 (38%)