Protein Alignment Shark and hir-1

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_504458.1
• Gene: hir-1 / 178936
• WormBaseID: WBGene00016059
• Length: 903
• Species: Caenorhabditis elegans
• Alignment Length: 301
• Identity: 100/301 - (33%)
• Similarity: 162/301 - (53%)
• Gaps: 45/301 - (14%)

  Fly   657 IEPEKLVL--DREIGHGEFGSVHSGWLLRKSGAGEES------------RLEVAIKML---SDEH 704
            ||...|::  |:::|.|.||:|:.|.|:.||.|.:::            ..:||:|||   :||.
 Worm   536 IERRNLIIHNDKKLGSGAFGAVYLGKLIGKSLAHKDANSPLGINLMRAENCQVAVKMLPEYADEM 600

  Fly   705 SNKQEFLREASVMMRL-EHKCIVRLIG-IAKGEMLMMVQELAPLGSMLQYI---------LD--- 755
            | |.|||||.::|..| .|:.:|.::. :.:.|.|.:|.|....|.:|:::         ||
 Worm   601 S-KHEFLREIALMKTLGYHERLVNMLACVTESEPLCLVVEYCDNGDLLKFLRERCKYMMKLDDLG 664

  Fly   756 -HGHE-----------ITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDF 808
             :.|:           |....:|..:|.||:.|:.||..:.|||||:||||:|:......||.||
 Worm   665 INYHDPPENENYDTNMIVTLKQLLQFAVQISYGLEYLSQKGFVHRDVAARNVLVHEGTACKIGDF 729

  Fly   809 GMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISN 873
            |:.|.:....::|: ::||:.|::|.:||:.....||..||:||||:.::|:.:||..||..:..
 Worm   730 GLCRYIYADQSQYK-SKGGKLPLKWMSPEAIRHYEFSIKSDIWSFGILLFEVITLGGSPYPGMPP 793

  Fly   874 VDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTF 914
            .|.:..::.|.|:.:|:.||...|.||..||...|.||..|
 Worm   794 EDVLPFLEGGGRIEKPDNCPENFYDVMMQCWNADPDDRIEF 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		ANKYR	<94..317	CDD:440430
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		SH2_Cterm_shark_like	287..395	CDD:198211
		PTKc_Syk_like	666..926	CDD:270650	96/290 (33%)
hir-1	NP_504458.1	fn3	85..164	CDD:394996
		RGP	227..>281	CDD:385243
		PTKc	547..842	CDD:270623	96/290 (33%)