Protein Alignment Shark and plc-3

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_496205.2
• Gene: plc-3 / 174586
• WormBaseID: WBGene00004038
• Length: 1350
• Species: Caenorhabditis elegans
• Alignment Length: 442
• Identity: 96/442 - (21%)
• Similarity: 164/442 - (37%)
• Gaps: 161/442 - (36%)

  Fly    10 WYHGNLSREAADELLKQGYEDGTFLVRESSTAAGDFVLSLLCQGEVCHYQVRRHGGEDAFFSIDD 74
            |:.....:|.|:|||....|||.||:|.|||.:..:||||...||..||:::|.|   ..|.::.
 Worm   715 WFSATADKEKAEELLSLVPEDGAFLIRTSSTDSSVYVLSLKVDGEFWHYRLKRDG---RIFVVNQ 776

  Fly    75 KVQTKILHGLDTLVDYY--QQAANGLPTKLTVPLIRDLPPHNTRSHGVTNLLHRATSKNESKVVF 137
            ||    ...|:.:|::|  ::...|:..:..|                       ..|:.|.:..
 Worm   777 KV----FENLNQIVEFYANREFVRGISLRFPV-----------------------NEKDISHLTA 814

  Fly   138 ELLK-----CGYRNFDAKNQDGQT---ALHLAALHSDEDILKHLLNAKVQVNSSDSFGCQPLHYA 194
            ||.:     |   ..|.|:.|.:.   ||......:|:::
 Worm   815 ELAEARTPGC---YMDLKDLDKEVQARALRPYRGTADDEL------------------------- 851

  Fly   195 ARSKPASFIRTLISAQANV-QGRNIDNGYVPLHEAAKHGNLEA------VQELLLAEAPPLPRTS 252
              |.||:.|.|::..:..: :||              :|:|..      |||:|     |...::
 Worm   852 --SFPANVIITVLRKEEGLWRGR--------------YGSLTGWFPSAHVQEIL-----PEKVST 895

  Fly   253 SGEFPFDLAKEAGQTAVE-----------------EFLLN--YKLPPANTTR--DQWYHG--TLT 294
            |....::..:.|| |.:|                 :..:|  |.|..|:::.  |.|.:.  .||
 Worm   896 SETSNYNTIELAG-TLIERIHDADRPNVIRISQSNQHWMNKQYYLLAASSSEEADGWQNNLFELT 959

  Fly   295 R--EEAVAILKKHAKELLAKQPEVDTSGCFLVRYSES----PA-------------ASGLVLTLL 340
            |  ...::||:...||   |:...:.|.  ||.|.::    ||             ..|.:
 Worm   960 RSVNTKMSILRTKEKE---KRIAAELSN--LVVYCQAVPFDPAHIYNDAFYEMCSFVEGKL---- 1015

  Fly   341 CDQVVK------NFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIA 386
             |::|:      |.| ..:.:|.||:::.|..     ....|.|.:..|::|
 Worm  1016 -DKLVEKGLLPFNSR-KLSRVYPNGSRITSNN-----YSPVPMWNAGCHMVA 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	30/80 (38%)
		ANKYR	<94..317	CDD:440430	46/262 (18%)
		ANK repeat	124..151	CDD:293786	6/31 (19%)
		ANK repeat	153..184	CDD:293786	4/33 (12%)
		ANK repeat	186..217	CDD:293786	6/31 (19%)
		ANK repeat	220..245	CDD:293786	6/30 (20%)
		SH2_Cterm_shark_like	287..395	CDD:198211	28/127 (22%)
		PTKc_Syk_like	666..926	CDD:270650
plc-3	NP_496205.2	PH-like	74..191	CDD:473070
		EFh_PI-PLC	196..339	CDD:333715
		EF-hand motif	196..226	CDD:320029
		EF-hand motif	233..254	CDD:320029
		EF-hand motif	259..292	CDD:320029
		EF-hand motif	302..339	CDD:320029
		PI-PLCc_GDPD_SF	351..>494	CDD:472694
		SH2_N-SH2_PLC_gamma_like	600..696	CDD:199829
		SH2_C-SH2_PLC_gamma_like	710..813	CDD:198186	35/127 (28%)
		SH3	833..886	CDD:214620	12/93 (13%)
		PLCYc	983..1092	CDD:128454	19/91 (21%)
		C2_PLC_like	1110..1222	CDD:175974