DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Shark and Matk

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	XP_006513357.1	Gene:	Matk / 17179	MGIID:	99259	Length:	506	Species:	Mus musculus

Alignment Length:	291	Identity:	107/291 - (36%)
Similarity:	164/291 - (56%)	Gaps:	20/291 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   634 RKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIK 698
            |:..|..|    .|.|.||..:.::.:.|.|..:||.||||:|..|..|.:         :||:|
Mouse   210 RRKQGAKS----AEEELAKAGWLLDLQHLTLGAQIGEGEFGAVLQGEYLGQ---------KVAVK 261

  Fly   699 MLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHGHEITAN 763
            .:..: ...|.||.|.:||.:|:|:.:|||:|:.....|.:|.|....|:::.::...|..:.:.
Mouse   262 NIKCD-VTAQAFLDETAVMTKLQHRNLVRLLGVILHHGLYIVMEHVSKGNLVNFLRTRGRALVST 325

  Fly   764 AELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGR 828
            ::|..:|..:|.||.||||:..|||||||||||::....||:||||::::.|.|      ....|
Mouse   326 SQLLQFALHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKG------LDSSR 384

  Fly   829 WPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCP 893
            .|::|.|||:...|.||..||||||||.:||:||.|..||.::|..:..:.|:.|.|:..|:.||
Mouse   385 LPVKWTAPEALKNGRFSSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPDGCP 449

  Fly   894 AYIYAVMQSCWKERPKDRPTFVYLTEFFARD 924
            ..::.:|.|||:..|..||.|..:.|...|:
Mouse   450 GSVHTLMGSCWEAEPARRPPFRKIVEKLGRE 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560
		ANK	117..241	CDD:238125
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		Ank_2	158..247	CDD:289560
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		Ank_4	224..274	CDD:290365
		SH2_Cterm_shark_like	287..395	CDD:198211
		TyrKc	662..921	CDD:197581	99/258 (38%)
		PTKc_Syk_like	666..926	CDD:270650	98/259 (38%)
Matk	XP_006513357.1	SH3	49..107	CDD:388381
		SH2_csk_like	117..214	CDD:198190	1/3 (33%)
		PKc_like	227..480	CDD:389743	99/268 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810