Protein Alignment Shark and spe-8

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_490680.1
• Gene: spe-8 / 171606
• WormBaseID: WBGene00004962
• Length: 512
• Species: Caenorhabditis elegans
• Alignment Length: 282
• Identity: 80/282 - (28%)
• Similarity: 150/282 - (53%)
• Gaps: 23/282 - (8%)

  Fly   660 EKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQE---FLREASVMMRLE 721
            |::.|::::|.|:||.||.|.|.....|   :.:.||:|.|...|.:..|   |||||:||:.|.
 Worm   215 EQVTLNKKLGEGQFGEVHKGSLKTSVFA---APVTVAVKTLHQNHLSANEKILFLREANVMLTLS 276

  Fly   722 HKCIVRLIGI-AKGEMLMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHF 785
            |..:::..|: ...|.:|:|.|.....|:...:|....:::|..:: ::....|||:.||..:..
 Worm   277 HPNVIKFYGVCTMKEPIMIVMEFCDGKSLEDALLSKEEKVSAEDKI-LYLFHAACGIDYLHGKQV 340

  Fly   786 VHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDV 850
            :|||:||||.||.::...||||||:|..    ....:..:||..|:::.|||:...|::|.|||:
 Worm   341 IHRDIAARNCLLNSKKILKISDFGLSVK----GVAIKERKGGCLPVKYMAPETLKKGLYSTASDI 401

  Fly   851 WSFGVTIWEMFSLGAPPYGEISNV--DAIKLVDSGERLPQPNLC-----PAYIYAVMQSCWKERP 908
            :|:|..::|:::.|..|: |...:  :.::....|:|:   :|.     |.:|..:.:...:...
 Worm   402 YSYGALMYEVYTDGKTPF-ETCGLRGNELRKAIIGKRI---SLAVEVELPVFIANIFEQSRQYET 462

  Fly   909 KDRPTFVYLTEFFARDPDYQNL 930
            :||.:...:.:.|..:..:..:
 Worm   463 EDRISSKQIIQIFKEEVGFHEI 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		ANKYR	<94..317	CDD:440430
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		SH2_Cterm_shark_like	287..395	CDD:198211
		PTKc_Syk_like	666..926	CDD:270650	78/270 (29%)
spe-8	NP_490680.1	SH2_Fps_family	109..195	CDD:198224
		PTKc	221..476	CDD:270623	77/266 (29%)