DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and Lyn

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001104566.1 Gene:Lyn / 17096 MGIID:96892 Length:512 Species:Mus musculus


Alignment Length:282 Identity:100/282 - (35%)
Similarity:164/282 - (58%) Gaps:18/282 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly   657 IEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLE 721
            |..|.:.|.:::|.|:||.|..|:.        .:..:||:|.|.....:.|.||.||::|..|:
Mouse   242 IPRESIKLVKKLGAGQFGEVWMGYY--------NNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQ 298

  Fly   722 HKCIVRLIG-IAKGEMLMMVQELAPLGSMLQYI-LDHGHEITANAELKVWASQIACGMHYLESQH 784
            |..:|||.. :.|.|.:.::.|....||:|.:: .|.|.::.. .:|..:::|||.||.|:|.::
Mouse   299 HDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGGKVLL-PKLIDFSAQIAEGMAYIERKN 362

  Fly   785 FVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASD 849
            ::||||.|.|:|::.....||:|||::|.:.  ..||...:|.::||:|.|||:.|.|.|:..||
Mouse   363 YIHRDLRAANVLVSESLMCKIADFGLARVIE--DNEYTAREGAKFPIKWTAPEAINFGCFTIKSD 425

  Fly   850 VWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTF 914
            |||||:.::|:.:.|..||...:|.|.:..:..|.|:|:...||..:|.:|:.||||:.::||||
Mouse   426 VWSFGILLYEIVTYGKIPYPGRTNADVMSALSQGYRMPRMENCPDELYDIMKMCWKEKAEERPTF 490

  Fly   915 VY----LTEFF-ARDPDYQNLP 931
            .|    |.:|: |.:..||..|
Mouse   491 DYLQSVLDDFYTATEGQYQQQP 512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211
TyrKc 662..921 CDD:197581 93/264 (35%)
PTKc_Syk_like 666..926 CDD:270650 94/266 (35%)
LynNP_001104566.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..45
SH3_Lyn 67..122 CDD:212937
SH2_Src_Lyn 125..225 CDD:198227
PTKc_Lyn 239..510 CDD:270657 98/278 (35%)
Pkinase_Tyr 247..497 CDD:285015 92/260 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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