DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shark and Jak2

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_001041642.1	Gene:	Jak2 / 16452	MGIID:	96629	Length:	1132	Species:	Mus musculus

Alignment Length:	962	Identity:	210/962 - (21%)
Similarity:	333/962 - (34%)	Gaps:	305/962 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 HGNLSRE-AADELLKQGYEDGTFLVRESSTAAGDFVLSLLCQGE-VCHYQVRRHGGEDAFFSIDD 74
            ||.:|.: |..:|.|.|.:.|.:::|.|......:.|:...:.| |..|:
Mouse   401 HGPISMDFAISKLKKAGNQTGLYVLRCSPKDFNKYFLTFAVERENVIEYK--------------- 450

  Fly    75 KVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNLLHRATSKNESKVVFEL 139
                   |.|.|..:..:...:|  ||.....::||          .|.....|.:::| ::|:.
Mouse   451 -------HCLITKNENGEYNLSG--TKRNFSNLKDL----------LNCYQMETVRSDS-IIFQF 495

  Fly   140 LKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSFGCQPLHYAARSKPASFIR 204
            .||    ...|.:|....|........:..:...|.....||       |.:.:..|::...|..
Mouse   496 TKC----CPPKPKDKSNLLVFRTNGISDVQISPTLQRHNNVN-------QMVFHKIRNEDLIFNE 549

  Fly   205 TLISAQANVQG--RNIDNGYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSSGEFPFDLAKEAGQT 267
            :|      .||  ..|..|.  ..|...:|.|... |:||.......|..|..| |:.|....|.
Mouse   550 SL------GQGTFTKIFKGV--RREVGDYGQLHKT-EVLLKVLDKAHRNYSESF-FEAASMMSQL 604

  Fly   268 AVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAI------------LKKHAKEL-------LAKQ 313
            :.:..:|||.:             .:..||.:.:            |||:...:       :|||
Mouse   605 SHKHLVLNYGV-------------CVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLGVAKQ 656

  Fly   314 PEVDTSGCFLVRYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYW 378
            .      .:.:.:.|.   ..|:...:|   .||..:.:.:..:.||      ..|:.:.|
Mouse   657 L------AWAMHFLEE---KSLIHGNVC---AKNILLIREEDRRTGN------PPFIKLSD---- 699

  Fly   379 PSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQ 443
            |.:                               |...:|:..::.:.  |..||..:
Mouse   700 PGI-------------------------------SITVLPKDILQERI--PWVPPECI------- 724

  Fly   444 HPHVPALTITKKKQKENSSSMFNTLRLTSPK---------------KALFDMNSLRKNKSKGKRS 493
                           ||..:    |.|.:.|               |.|..::|.||
Mouse   725 ---------------ENPKN----LNLATDKWSFGTTLWEICSGGDKPLSALDSQRK-------- 762

  Fly   494 DSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEID 558
                     |...|.:.|..||....|:                         |:..|....|.|
Mouse   763 ---------LQFYEDKHQLPAPKWTELA-------------------------NLINNCMDYEPD 793

  Fly   559 LPPIAQKTEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNAS 623
            ..|..:....::......|..:..|       |...|.|                |:.:||
Mouse   794 FRPAFRAVIRDLNSLFTPDYELLTE-------NDMLPNM----------------RIGALG---- 831

  Fly   624 TESEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAG 688
                        .||.......|:.|...|:|.         :::|.|.||||.   :.|.....
Mouse   832 ------------FSGAFEDRDPTQFEERHLKFL---------QQLGKGNFGSVE---MCRYDPLQ 872

  Fly   689 EESRLEVAIKMLSDEHSNKQ---EFLREASVMMRLEHKCIVRLIGI---AKGEMLMMVQELAPLG 747
            :.:...||:|.|  :||.::   :|.||..::..|:|..||:..|:   |....|.::.|..|.|
Mouse   873 DNTGEVVAVKKL--QHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYG 935

  Fly   748 SMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSR 812
            |:..|:..|...|. :.:|..:.|||..||.||.::.::|||||.||||:...::.||.|||:::
Mouse   936 SLRDYLQKHKERID-HKKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTK 999

  Fly   813 SLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFS--------------- 862
            .|......|:..:.|..||.||||||.....||.|||||||||.::|:|:
Mouse  1000 VLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPVEFMRM 1064

  Fly   863 LGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTF 914
            :|....|::.....|:|:.|..|||:|..||..||.:|..||......||:|
Mouse  1065 IGNDKQGQMIVFHLIELLKSNGRLPRPEGCPDEIYVIMTECWNNNVSQRPSF 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	17/80 (21%)
		Ank_2	<112..184	CDD:289560	12/71 (17%)
		ANK	117..241	CDD:238125	24/125 (19%)
		ANK repeat	124..151	CDD:293786	5/26 (19%)
		ANK repeat	153..184	CDD:293786	5/30 (17%)
		Ank_2	158..247	CDD:289560	18/90 (20%)
		ANK repeat	186..217	CDD:293786	6/32 (19%)
		ANK repeat	220..245	CDD:293786	7/24 (29%)
		Ank_4	224..274	CDD:290365	12/49 (24%)
		SH2_Cterm_shark_like	287..395	CDD:198211	18/126 (14%)
		TyrKc	662..921	CDD:197581	95/274 (35%)
		PTKc_Syk_like	666..926	CDD:270650	95/270 (35%)
Jak2	NP_001041642.1	Interaction with cytokine/interferon/growth hormone receptors	1..239
		FERM_F1	39..134	CDD:408179
		FERM_F2	143..261	CDD:408177
		FERM_C_JAK2	266..386	CDD:270141
		SH2_Jak2	386..482	CDD:198242	23/114 (20%)
		PTK_Jak2_rpt1	545..806	CDD:270663	65/406 (16%)
		PTKc_Jak2_rpt2	844..1127	CDD:271107	98/288 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900