DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shark and Jak1

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	NP_666257.2	Gene:	Jak1 / 16451	MGIID:	96628	Length:	1153	Species:	Mus musculus

Alignment Length:	979	Identity:	223/979 - (22%)
Similarity:	342/979 - (34%)	Gaps:	340/979 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 HGNLSRE-AADELLKQGYEDGTFLVRESSTAAGDFVLSLLC--QGEVCHYQVRRHGGEDAFFSID 73
            ||.:..| |.::|.::|.|:|.:::|.|.|...:.::::.|  :.||.       ||:..|
Mouse   441 HGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEVL-------GGQKQF---- 494

  Fly    74 DKVQTKILHGLDTLVDYYQQAANGLPTKLTVPLIRDLPPHNTRSHGVTNLLHRATSKNESKVVFE 138

Mouse   495 ----------------------------------------------------------------- 494

  Fly   139 LLKCGYRNFDAKNQDGQTALHLAALH--SDEDILKHLLNAKVQVNSSDSFG------CQPLHYAA 195
                  :||..:.|.|:.:||.:..|  |..|::.||   |.|:..:|:..      |||
Mouse   495 ------KNFQIEVQKGRYSLHGSMDHFPSLRDLMNHL---KKQILRTDNISFVLKRCCQP----- 545

  Fly   196 RSKPASFIRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSSGEFPFD- 259
              ||                |.|.|..|...:|         ||.       .|..|..:..||
Mouse   546 --KP----------------REISNLLVATKKA---------QEW-------QPVYSMSQLSFDR 576

  Fly   260 -LAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTL---TREEAVAILKKHAKELLAKQP-EVDTS 319
             |.|:..|   .|.|       ...||...|.|||   ..||.:|..||....|....| ..|.|
Mouse   577 ILKKDIIQ---GEHL-------GRGTRTHIYSGTLLDYKDEEGIAEEKKIKVILKVLDPSHRDIS 631

  Fly   320 GCFLVRYSESPAASGLVLTLL---CDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSV 381
            ..|....|.....|...:..|   |.:.|:|..:.:                  :::.||.
Mouse   632 LAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEE------------------FVEGGPL---- 674

  Fly   382 EHLIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPH 446
             .|..|  |.|..|....|:.|..|                   .||
Mouse   675 -DLFMH--RKSDALTTPWKFKVAKQ-------------------LAS------------------ 699

  Fly   447 VPALTITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSD-------SESSVSGSLA 504
              ||:..:.|...:.:.....|.|.                .:|..||       |:..:..|:.
Mouse   700 --ALSYLEDKDLVHGNVCTKNLLLA----------------REGIDSDIGPFIKLSDPGIPVSVL 746

  Fly   505 GTEQELQAAAPML--------KSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPP 561
             |.||.....|.:        |:||.:.:..:|   |.|.......||:               |
Mouse   747 -TRQECIERIPWIAPECVEDSKNLSVAADKWSF---GTTLWEICYNGEI---------------P 792

  Fly   562 IAQKTEAEVEYFTKS----------DVAIERERAGQWIGNG---YQPTMDVLSLLDQQIKAPAVA 613
            :..||..|.|.|.:|          ::|....|...:..|.   ::..|..::.|::|
Mouse   793 LKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQ------- 850

  Fly   614 RLNSLGPNASTESEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLD--REIGHGEFGSV 676
                 .|:..:|.:                ..|||:....      ||..|.  |::|.|.||.|
Mouse   851 -----NPDIVSEKQ----------------PTTEVDPTHF------EKRFLKRIRDLGEGHFGKV 888

  Fly   677 HSGWLLRKSGAGEESRLEVAIKMLSDEHSNKQ--EFLREASVMMRLEHKCIVRLIGIAK---GEM 736
            .   |.|....|:.:..:||:|.|..|.....  :..:|..::..|.|:.||:..||..   |..
Mouse   889 E---LCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICMEDGGNG 950

  Fly   737 LMMVQELAPLGSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARH 801
            :.::.|..|.||:.:|:..:.::|....:|| :|.||..||.||.|:.:|||||||||:|:.:.|
Mouse   951 IKLIMEFLPSGSLKEYLPKNKNKINLKQQLK-YAIQICKGMDYLGSRQYVHRDLAARNVLVESEH 1014

  Fly   802 QAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFS---- 862
            |.||.|||:::::......|........|:.|||||......|..||||||||||:.|:.:
Mouse  1015 QVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDS 1079

  Fly   863 ----------LGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYL 917
                      :..|.:|:::....:..:..|:|||.|..||..:|.:|:.||:.:|.:|.||..|
Mouse  1080 DFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTTFQNL 1144

  Fly   918 TEFF 921
            .|.|
Mouse  1145 IEGF 1148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	17/81 (21%)
		Ank_2	<112..184	CDD:289560	13/73 (18%)
		ANK	117..241	CDD:238125	26/131 (20%)
		ANK repeat	124..151	CDD:293786	2/26 (8%)
		ANK repeat	153..184	CDD:293786	10/32 (31%)
		Ank_2	158..247	CDD:289560	22/96 (23%)
		ANK repeat	186..217	CDD:293786	5/36 (14%)
		ANK repeat	220..245	CDD:293786	5/24 (21%)
		Ank_4	224..274	CDD:290365	11/51 (22%)
		SH2_Cterm_shark_like	287..395	CDD:198211	26/114 (23%)
		TyrKc	662..921	CDD:197581	94/279 (34%)
		PTKc_Syk_like	666..926	CDD:270650	94/275 (34%)
Jak1	NP_666257.2	FERM_F1	<52..129	CDD:408179
		FERM_F2	147..277	CDD:408177
		FERM_C_JAK1	282..426	CDD:275412
		SH2_Jak1	426..526	CDD:198241	28/169 (17%)
		PTK_Jak1_rpt1	582..845	CDD:270662	70/371 (19%)
		PTKc_Jak1_rpt2	869..1152	CDD:173644	97/290 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0197
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810