DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and Itk

DIOPT Version :10

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001268894.1 Gene:Itk / 16428 MGIID:96621 Length:625 Species:Mus musculus


Alignment Length:349 Identity:63/349 - (18%)
Similarity:113/349 - (32%) Gaps:130/349 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   604 QTCTHGIMGQSSDKIVAAAAKKLMEFVQTRLFEPNVAGQLVGCLVRLFARIHGREVLRV--LLPH 666
            |||:..:.....|.:|                   ::|:.:...:|..||....|.:..  ..||
Mouse    17 QTCSFHLSSSRQDAVV-------------------ISGRKLARQIRNEARDDVEEWVSAGNRRPH 62

  Fly   667 V-LRLIEDYMGEHDEV--------------EELEK----HNDEMLYYLVLLSNLVRGDPRIIR-- 710
            : :.|:.|....|..|              |.:.|    ..:|:|..:|.|::..|.|..:::  
Mouse    63 LSVVLVGDNPASHSYVLNKTRAAAEVGISSETILKPSNISEEELLDLIVKLNSDHRVDGLLVQLP 127

  Fly   711 --NYVDDLLPTLDRLANFKC--KRVARYLAQIVGNLMNNMSTVQTMDIRNSPDCFQKPLSEIVPV 771
              :::|:     .|:.|..|  |.|..:....||.:..:.||                   ::|.
Mouse   128 LPDHIDE-----RRVCNAVCPGKDVDGFHVVNVGRMCLDQST-------------------MLPA 168

  Fly   772 KRWG----------EKMAPDGKIEWRVPDEGARAVC--------ER--------IMHRYLPGLLA 810
            ..||          |.:..:..:..|..:.|.....        ||        |.|||      
Mouse   169 TPWGVWEIIKRTGIETLGKNVLVAGRSKNVGMPIAMLLHTDGRHERPGGDATVTISHRY------ 227

  Fly   811 KLEQHSAGEVTLPREELHRSVMMVQALIRCYNFLPNWTDEEPIKLFETCVDL---REL------- 865
                       .|:|:|.:...:...::.... :||....:.||.....:|:   |.|       
Mouse   228 -----------TPKEQLRQHTKIADIIVAAAG-IPNLITADMIKEGAAVIDVGINRILDPMTGKN 280

  Fly   866 QLNVTLGFEGLEIR------MPGG 883
            :|...:.|||:..:      :|||
Mouse   281 RLVGDVDFEGVRKKASFITPVPGG 304

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
SH2_Cterm_shark_like 287..395 CDD:198211
PTKc_Syk_like 666..926 CDD:270650 52/285 (18%)
ItkNP_001268894.1 PH_Btk 7..154 CDD:269944 30/160 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 153..174 7/39 (18%)
SH3_ITK 180..235 CDD:212841 12/71 (17%)
SH2_Tec_Itk 238..345 CDD:198259 14/68 (21%)
PTKc_Itk 363..618 CDD:133243
Blue background indicates that the domain is not in the aligned region.

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