DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and Hck

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_034537.2 Gene:Hck / 15162 MGIID:96052 Length:524 Species:Mus musculus


Alignment Length:577 Identity:151/577 - (26%)
Similarity:259/577 - (44%) Gaps:101/577 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   398 SLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHP-HVPALTITKKKQKENS 461
            |.:.|..|:.:...|....:     |.:.....:..:...|.::.:.| :||..|.:.|....||
Mouse     6 SCEDPGCPRSEGRAPRMGCV-----KSRFLRDGSKASKTEPSANQKGPVYVPDPTSSSKLGPNNS 65

  Fly   462 SSM--------FNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLK 518
            :||        .:|:.:     ||:|..::.:.....::.|.           ...|:.|....|
Mouse    66 NSMPPGFVEGSEDTIVV-----ALYDYEAIHREDLSFQKGDQ-----------MVVLEEAGEWWK 114

  Fly   519 SLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEV-EYFTKSDVAIER 582
            :.|.:|:...:                  :|.|.         :|:....|. |:|.|.....:.
Mouse   115 ARSLATKKEGY------------------IPSNY---------VARVNSLETEEWFFKGISRKDA 152

  Fly   583 ER----AGQWIGN----GYQPTMDVLSL----LDQQ----IKAPAVARLNS----LGPNASTESE 627
            ||    .|..:|:    ..:.|....||    .|.|    :|...:..|:|    :.|.::..|.
Mouse   153 ERHLLAPGNMLGSFMIRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISPRSTFSSL 217

  Fly   628 MASYLHRK------CS--GTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRK 684
            ....||.|      |.  ..|......:....|..:.|..|.|.:::::|.|:||.|   |:   
Mouse   218 QELVLHYKKGKDGLCQKLSVPCVSPKPQKPWEKDAWEIPRESLQMEKKLGAGQFGEV---WM--- 276

  Fly   685 SGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSM 749
              |......:||:|.:.....:.:.||.||::|..|:|..:|:|..:...|.:.:|.|....||:
Mouse   277 --ATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKSLQHDKLVKLHAVVSQEPIFIVTEFMAKGSL 339

  Fly   750 LQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSL 814
            |.::...........:|..:::||:.||.::|.::::||||.|.|||::|....||:|||::|.:
Mouse   340 LDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARII 404

  Fly   815 RPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKL 879
            .  ..||...:|.::||:|.|||:.|.|.|:..|||||||:.:.|:.:.|..||..:||.:.|:.
Mouse   405 E--DNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRA 467

  Fly   880 VDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVY----LTEFF-ARDPDYQNLP 931
            ::.|.|:|:|:.||..:|.:|..|||.||::||||.|    |.:|: |.:..||..|
Mouse   468 LEHGYRMPRPDNCPEELYNIMIRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP 524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211
TyrKc 662..921 CDD:197581 92/262 (35%)
PTKc_Syk_like 666..926 CDD:270650 93/264 (35%)
HckNP_034537.2 SH3 80..135 CDD:302595 12/97 (12%)
SH2_Src_HCK 138..241 CDD:198226 23/102 (23%)
PKc_like 252..522 CDD:304357 97/279 (35%)
Pkinase_Tyr 260..509 CDD:285015 91/258 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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