Protein Alignment Shark and Fgfr4

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: XP_006517162.3
• Gene: Fgfr4 / 14186
• MGIID: 95525
• Length: 829
• Species: Mus musculus
• Alignment Length: 699
• Identity: 179/699 - (25%)
• Similarity: 273/699 - (39%)
• Gaps: 186/699 - (26%)

  Fly   337 LTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPVSLKY 401
            ||||.|..:.:  ||..   ::...:.|..|..:|....|||...:.:.........|..|..:.
Mouse   140 LTLLMDDSLTS--ISND---EDPKTLSSSSSGHVYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRC 199

  Fly   402 PVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHS---------HHQH------PHVPALT 451
            |....|.|.:        ..:|...|.          |.         .|||      ..||:..
Mouse   200 PAAGNPMPTI--------HWLKDGQAF----------HGENRIGGIRLRHQHWSLVMESVVPSDR 246

  Fly   452 ITKKKQKENS------SSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQEL 510
            .|.....|||      |.:.:.|. .||.:.:... .|..|.:             ::.|::.||
Mouse   247 GTYTCLVENSLGSIRYSYLLDVLE-RSPHRPILQA-GLPANTT-------------AVVGSDVEL 296

  Fly   511 -----QAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEV 570
                 ..|.|.::.|....         :.||...|.|..|......|.|        ..:|.||
Mouse   297 LCKVYSDAQPHIQWLKHVV---------INGSSFGADGFPYVQVLKTTDI--------NSSEVEV 344

  Fly   571 EYFTKSDVAIERERAGQW-------IGNGYQ-------PTMD----------------------- 598
            .|...    :..|.||::       ||..||       |..|
Mouse   345 LYLRN----VSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDLTWTTATPEARYTDIILYVSGSL 405

  Fly   599 ---VLSLLD-------------------QQIKAPAVARLNSLGPNASTESEMASY--LHRKCSGT 639
               ||.||.                   |::....:||..||...:|.:|.::..  :....||.
Mouse   406 VLLVLLLLAGVYHRQVIRGHYSRQPVTIQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGP 470

  Fly   640 PSTPSATEVEAAKLRFFIEP------EKLVLDREIGHGEFGSVHSGWLLRKSGAG-EESRLE--- 694
            |.......::..     ::|      ::|||.:.:|.|.||.|     :|....| :.||.:
Mouse   471 PLLTGLVNLDLP-----LDPLWEFPRDRLVLGKPLGEGCFGQV-----VRAEAFGMDPSRPDQTS 525

  Fly   695 -VAIKMLSDEHSNKQ--EFLREASVMMRL-EHKCIVRLIGIAKGE-MLMMVQELAPLGSMLQYIL 754
             ||:|||.|..|:|.  :.:.|..||..: .||.|:.|:|:...| .|.::.|.|..|::.:::.
Mouse   526 TVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLR 590

  Fly   755 DH---GHEITANA-----------ELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKI 805
            ..   |.:::.:.           .|...|.|:|.||.||||:..:||||||||:|:|.....||
Mouse   591 ARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKI 655

  Fly   806 SDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGE 870
            :|||::|.:. ....|:.|..||.|::|.|||:....:::|.|||||||:.:||:|:||..||..
Mouse   656 ADFGLARGVH-HIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPG 719

  Fly   871 ISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTE 919
            |...:...|:..|.|:.:|..||:.:|.:|:.||...|..||||..|.|
Mouse   720 IPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVE 768

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		ANKYR	<94..317	CDD:440430
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		SH2_Cterm_shark_like	287..395	CDD:198211	13/57 (23%)
		PTKc_Syk_like	666..926	CDD:270650	99/277 (36%)
Fgfr4	XP_006517162.3	IG_like	70..143	CDD:214653	2/2 (100%)
		Ig strand B	80..84	CDD:409353
		Ig strand E	111..115	CDD:409353
		Ig strand F	125..130	CDD:409353
		Ig	174..268	CDD:472250	21/111 (19%)
		Ig strand B	195..199	CDD:409353	1/3 (33%)
		Ig strand C	208..212	CDD:409353	0/11 (0%)
		Ig strand E	234..238	CDD:409353	0/3 (0%)
		Ig strand F	248..253	CDD:409353	1/4 (25%)
		Ig strand G	261..264	CDD:409353	0/2 (0%)
		Ig	276..378	CDD:472250	26/136 (19%)
		Ig strand B	294..298	CDD:409353	2/3 (67%)
		Ig strand C	307..311	CDD:409353	0/3 (0%)
		Ig strand E	343..347	CDD:409353	2/3 (67%)
		Ig strand F	357..362	CDD:409353	0/4 (0%)
		Ig strand G	370..373	CDD:409353	2/2 (100%)
		PTKc_FGFR4	481..794	CDD:133230	103/299 (34%)