Protein Alignment Shark and Btk29A

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: XP_061512228.1
• Gene: Btk29A / 1277670
• VectorBaseID: AGAMI1_007842
• Length: 810
• Species: Anopheles gambiae
• Alignment Length: 634
• Identity: 163/634 - (25%)
• Similarity: 267/634 - (42%)
• Gaps: 153/634 - (24%)

  Fly   403 VPPQPKPE----------VPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQ 457
            |.||.:|:          ||......:...:|:       ||...|..|.| .|.|:|......|
Mosquito   208 VHPQQQPQQQQLQHHSGTVPVLQAHQQQQQQPQ-------PTQHPPQQHSQ-SHSPSLQHPAASQ 264

  Fly   458 -----KENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPML 517
                 ::..:::...|:...|     .:...:.::......:|.||..|::..| ...|..:|.:
Mosquito   265 QQVHLQQQQAALQAALQQQQP-----PLLQQQTSQQSSHHLNSSSSSLGNITPT-FVAQPQSPTV 323

  Fly   518 KSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRN-----NTP------------IEIDLPP---- 561
            .|      |.|.:.:|| |......|:: |:|..     .||            |.:.|.|
Mosquito   324 NS------FKTASLNGV-GLHVNGGGDL-NMPGGPTVTPGTPNTKAKDVSPRVKIVVALYPFKAI 380

  Fly   562 ------IAQKTEAEV-----EYFTK------------SDVAIERERAG----QW-IGNGYQPTMD 598
                  :.:..|.||     |::.|            |:...|:|..|    .| :|:..:...:
Mosquito   381 ESGDLSLEKNAEYEVIDDSQEHWWKVKDQHGTIGYIPSNYVKEKELLGLQKYDWYVGDMSRQRAE 445

  Fly   599 VLSLLDQQIKAPA-VARLNS----------------------LGPNASTE------------SEM 628
              |||.|..|... |.|.:|                      :..||.:|            .::
Mosquito   446 --SLLKQNDKEGCFVVRKSSTKGLYTLSLHTKVPQSHVKHYHIKQNARSEFYLSEKHCCETIPDL 508

  Fly   629 ASYLHRKCSG------------TPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSV-HSGW 680
            .:| ||..||            .|..|:|   ..:..::.|.|.:|::..|:|.|:||.| .:.|
Mosquito   509 INY-HRHNSGGLACRLKTSPCDRPVPPTA---GLSHDKWEIHPSELMILEELGSGQFGVVRRAKW 569

  Fly   681 LLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGI-AKGEMLMMVQELA 744
                     ...::.|:||:.....::.:|:.||.||.:|:|..:|:|.|: :|...:.::.|..
Mosquito   570 ---------RGSIDTAVKMMKVGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIITEYM 625

  Fly   745 PLGSMLQYILDHGHEITANAELKV-WASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDF 808
            ..||:|.|:..|...:..|..|.: ...|:..||.|||..:::||||||||.|:.:.:..|::||
Mosquito   626 KHGSLLNYLRRHEQSLIGNMGLLLDMCIQVCKGMSYLERHNYIHRDLAARNCLVGSENTVKVADF 690

  Fly   809 GMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISN 873
            |::|.:.  ..:|..:.|.::||:|..||..|...||..||||::||.:||:|:.|..|||.:.|
Mosquito   691 GLARYVL--DDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEVFTCGKMPYGRLKN 753

  Fly   874 VDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYLTEFFA 922
            .:.::.|..|..|.:|..|...||.||:.||...|:|||.|..|.:..|
Mosquito   754 TEVVERVQRGIILEKPKACAKEIYDVMKKCWSHSPEDRPGFRILKDQLA 802

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		ANKYR	<94..317	CDD:440430
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786
		SH2_Cterm_shark_like	287..395	CDD:198211
		PTKc_Syk_like	666..926	CDD:270650	91/260 (35%)
Btk29A	XP_061512228.1	None