Protein Alignment Shark and sev

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: XP_061503032.1
• Gene: sev / 1272261
• VectorBaseID: AGAMI1_009976
• Length: 2555
• Species: Anopheles gambiae
• Alignment Length: 1114
• Identity: 254/1114 - (22%)
• Similarity: 396/1114 - (35%)
• Gaps: 345/1114 - (30%)

  Fly     2 SRDSDPMKWYHGNLSREAADELL-----KQGYEDGTFLVRESSTAAGDFVLSL----------LC 51
            |..|||:   |..:|..|...::     :.|..:   ||..|..|...:::||          .|
Mosquito  1387 SGGSDPV---HRMVSLPAEPAVIDLLQVRPGVAE---LVAVSRYARAGYIVSLDEPDREPTPFNC 1445

  Fly    52 QGEVC--HYQVRRHGGEDAFFSIDDKVQTKILHGL-------------DTLVDYYQQAANGLPTK 101
            .||..  .:..|..|..|..|.:|.:      ||:             |..|..  :|.:|.||.
Mosquito  1446 SGEDVENEWNQRLCGEYDGVFDVDGQ------HGIVQDEGYLYWIGPDDGTVSV--RARDGAPTS 1502

  Fly   102 ---------------LTVPLIRDLPPHNTRSHGVTNL--LHRATSKNESKVVFELLKCGYRNFDA 149
                           |.|...:..||.......|..:  |....:..||.:...|.: ..|:.|.
Mosquito  1503 DATTQQFPLTGAVVLLPVQHRQAYPPERCLVPVVQQIQYLPELYNNTESSITLRLPE-PERHTDC 1566

  Fly   150 KNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSDSFG-CQPL-----------HYAARSKPASF 202
            :.:  ..|:....|:..||.....|:......||.:.| .:|.           :|.|.:..|.
Mosquito  1567 ERR--PPAVRYRILYQQEDEASADLHIDYSYESSRTIGNLRPFTNYRFGVVLTSYYLAAATTAQ- 1628

  Fly   203 IRTLISAQANVQGRNIDNGYVPLHEAAKHGNLEAVQELLLAEAPPLPRTSSG--EFPFDLAKEAG 265
             |.|:                        |...::.||.....|.:.||:.|  ..|.|:.  |.
Mosquito  1629 -RLLV------------------------GGEPSITELPKRSMPVVFRTAVGPPSRPEDIT--AW 1666

  Fly   266 QTAVEEFLLNYKLPPANTTRDQWY---------HGTLTREEAVAILKKHAKELLAKQPEVDTSGC 321
            ..:..|.::::.......:...||         |.. .:::.|...|.....:..:...:..:..
Mosquito  1667 PVSPTEAIVSWIPSRQKNSHHVWYEIWRAEPDEHKN-RQQQVVTDFKMDDTSMTVEITRLQPNQT 1730

  Fly   322 FLV---------RYSES--------PAASGLVLTLLCDQVVK----------NFRISQADLYQNG 359
            ::|         .||:|        |..|.:.|..|....::          .::|..|.:
Mosquito  1731 YIVWVRAYSNFHAYSDSDKFQIQTFPEPSDIQLLSLNSTGIRLRWIPPVNCQKYKIQYAIV---- 1791

  Fly   360 NKVQSGGSKF--LYIDDGP--YWPSVEHLIAHFM-RFSYGLPVSLKYPVPPQPKPEVPSFATIPR 419
                 |.|.:  :|...||  :|.:..:.:...| :..|...|.|.||...:|       ...||
Mosquito  1792 -----GQSTWTTMYDSQGPSTHWYNYHYELNGLMPKTRYQFVVLLHYPYRDEP-------YVWPR 1844

  Fly   420 SN---MKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQ----------KENSSSMFNTLRLT 471
            ..   .:..|..||.|..|:               :||.:|          |:|.:.:
Mosquito  1845 ERDIIFETAADKPAAPGRPI---------------VTKLRQDVYKVSWEAAKDNGAII------- 1887

  Fly   472 SPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTG 536
             .:.||..:.|.....::...|..:.:.:|.|                           |.||.|
Mosquito  1888 -EEYALEVLVSQLNRAARFVLSPDDDTAAGEL---------------------------APGVEG 1924

  Fly   537 S-GAAAAGE----------VYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERE----RAG 586
            | |.|..||          |||                   ..:|.:......||:|.    ||.
Mosquito  1925 SNGTATVGELETYDERWSQVYN-------------------GTDVYWIIPERHAIQRNLFRVRAR 1970

  Fly   587 QWIGNG-----YQPT----------------------------MDVLSLLDQQIKA------PAV 612
            ...|.|     .:||                            :.|:.|:.|..|.      ||.
Mosquito  1971 NSYGWGPYSDESRPTGPELYVQRTIIYIATFVSTLGTIVVVVALTVIFLIRQTDKMKNFQMDPAN 2035

  Fly   613 ARLNSLG-------PNASTESEMASYLHRKCSGTPSTPSATEVEAAKL------RFFIEPEKLVL 664
            |||:.:.       |......:..:.|:       |:.|.|:.|.|.|      :.|:....|
Mosquito  2036 ARLSDVELANLRELPRRGNFVQTTNILY-------SSGSMTDSEIALLPRIRLDQIFMASSSL-- 2091

  Fly   665 DREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSD--EHSNKQEFLREASVMMRLEHKCIVR 727
               :|.|.||.|:.|.:   .|...|:...||||.|..  :...|||||:||.:|...:||.|.|
Mosquito  2092 ---LGSGAFGEVYEGVV---KGVDGEAETRVAIKTLKKGAKLHEKQEFLQEAQLMSNFKHKHITR 2150

  Fly   728 LIGIA-KGEMLMMVQELAPLGSMLQYILDHGHEITANA------ELKVWASQIACGMHYLESQHF 785
            |:|:. :.:.|:::.||...|.:|.| |.....:...|      :|......:|.|..|||..||
Mosquito  2151 LLGVCLEADALLIIMELMQGGDLLSY-LRRSRSLPGQAARLTMLDLISMCQDVASGCRYLEEMHF 2214

  Fly   786 VHRDLAARNILLTAR----HQAKISDFGMSRSLRPGSTEYQFTQG-GRWPIRWYAPESFNLGIFS 845
            ||||||.||.|:::.    ...||.|||::|.:.  ..:|...:| |..|:||.:|||...|:|:
Mosquito  2215 VHRDLACRNCLVSSTDPRDRVVKIGDFGLARDIY--KNDYYRKEGEGLLPVRWMSPESLVDGVFT 2277

  Fly   846 HASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKD 910
            ..||:|:|||.:||:.:||..||...:||:.:..|..|..|.:|.:||..:|.:|:.|||..|::
Mosquito  2278 SQSDIWAFGVLLWEIMTLGEQPYQAKNNVEVLNHVREGGHLDRPKVCPNEMYELMKYCWKFSPEE 2342

  Fly   911 RPTFVYLTE 919
            ||||.|..|
Mosquito  2343 RPTFRYCLE 2351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	22/112 (20%)
		ANKYR	<94..317	CDD:440430	45/262 (17%)
		ANK repeat	124..151	CDD:293786	6/26 (23%)
		ANK repeat	153..184	CDD:293786	6/30 (20%)
		ANK repeat	186..217	CDD:293786	7/42 (17%)
		ANK repeat	220..245	CDD:293786	3/24 (13%)
		SH2_Cterm_shark_like	287..395	CDD:198211	23/148 (16%)
		PTKc_Syk_like	666..926	CDD:270650	101/268 (38%)
sev	XP_061503032.1	None