Protein Alignment Shark and Btk

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: NP_038510.2
• Gene: Btk / 12229
• MGIID: 88216
• Length: 659
• Species: Mus musculus
• Alignment Length: 756
• Identity: 179/756 - (23%)
• Similarity: 284/756 - (37%)
• Gaps: 226/756 - (29%)

  Fly   229 AKHGNLE-----AVQELLLAEAPP----LPR--TSSGE-----------FPFDLAKEAGQTAVEE 271
            :|.|:::     .|:.::..:.||    :||  ..|.|           :||.:..:.|..
Mouse    51 SKKGSIDVEKITCVETVIPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPL---- 111

  Fly   272 FLLNYKLPPANTTRDQWYH--GTLTREEAVAILKKHAKELLAKQPEVDTSGCFLV--RYSESPAA 332
                |...|....|.:|.|  ..:.|..:..:.|.|.              ||.:  :|
Mouse   112 ----YVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHP--------------CFWIDGQY------ 152

  Fly   333 SGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPV 397
                  |.|.|..||                :.|.:.|...:|...|...|.
Mouse   153 ------LCCSQTAKN----------------AMGCQILENRNGSLKPGSSHR------------- 182

  Fly   398 SLKYPVPPQPK---------PEVPSFATIPRSNMKPKAA-----------------------SPA 430
            ..|.|:||.|:         |..|:.|.|..:.:|...|                       ..:
Mouse   183 KTKKPLPPTPEEDQILKKPLPPEPTAAPISTTELKKVVALYDYMPMNANDLQLRKGEEYFILEES 247

  Fly   431 TPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSD- 494
            ..|...:...:.|..::|:..||   :.|:|..|:...     .|.:....:.:..|.:||...
Mouse   248 NLPWWRARDKNGQEGYIPSNYIT---EAEDSIEMYEWY-----SKHMTRSQAEQLLKQEGKEGGF 304

  Fly   495 --SESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEI 557
              .:||.:|...                     .|.|         |.:.||...|.|:..   :
Mouse   305 IVRDSSKAGKYT---------------------VSVF---------AKSTGEPQGVIRHYV---V 336

  Fly   558 DLPPIAQKTEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNA 622
            ...|.:|...||...|:                     |:..|....|...|..::||
Mouse   337 CSTPQSQYYLAEKHLFS---------------------TIPELINYHQHNSAGLISRL------- 373

  Fly   623 STESEMASY-LHRKCSGTPSTPSATEVEAAKLRF---FIEPEKLVLDREIGHGEFGSVHSG-WLL 682
                   .| :.::....|||        |.|.:   .|:|:.|...:|:|.|:||.|..| |
Mouse   374 -------KYPVSKQNKNAPST--------AGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKW-- 421

  Fly   683 RKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGI-AKGEMLMMVQELAPL 746
                   ..:.:|||||:.:...::.||:.||.|||.|.|:.:|:|.|: .|...:.::.|....
Mouse   422 -------RGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMAN 479

  Fly   747 GSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMS 811
            |.:|.|:.:..|.......|:: ...:...|.||||:.|:||||||||.|:..:...|:||||:|
Mouse   480 GCLLNYLREMRHRFQTQQLLEM-CKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLS 543

  Fly   812 RSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDA 876
            |.:.  ..||..:.|.::|:||..||......||..||:|:|||.:||::|||..||...:|.:.
Mouse   544 RYVL--DDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSET 606

  Fly   877 IKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYL 917
            .:.:..|.||.:|:|....:|.:|.|||.|:..:||:|..|
Mouse   607 AEHIAQGLRLYRPHLASERVYTIMYSCWHEKADERPSFKIL 647

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		ANKYR	<94..317	CDD:440430	20/111 (18%)
		ANK repeat	124..151	CDD:293786
		ANK repeat	153..184	CDD:293786
		ANK repeat	186..217	CDD:293786
		ANK repeat	220..245	CDD:293786	3/20 (15%)
		SH2_Cterm_shark_like	287..395	CDD:198211	18/111 (16%)
		PTKc_Syk_like	666..926	CDD:270650	93/254 (37%)
Btk	NP_038510.2	PH_Btk	6..166	CDD:269944	29/164 (18%)
		Inositol-(1,3,4,5)-tetrakisphosphate 1-binding. /evidence=ECO:0000250|UniProtKB:Q06187	12..24
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	171..210		10/51 (20%)
		SH3_BTK	217..271	CDD:212839	7/56 (13%)
		SH2_Tec_Btk	274..378	CDD:198260	28/176 (16%)
		PTKc_Btk_Bmx	397..652	CDD:173657	96/263 (37%)
		CAV1-binding. /evidence=ECO:0000250|UniProtKB:Q06187	581..588		4/6 (67%)