| Sequence 1: | NP_524743.2 | Gene: | Shark / 44353 | FlyBaseID: | FBgn0015295 | Length: | 939 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_038510.2 | Gene: | Btk / 12229 | MGIID: | 88216 | Length: | 659 | Species: | Mus musculus |
| Alignment Length: | 756 | Identity: | 179/756 - (23%) |
|---|---|---|---|
| Similarity: | 284/756 - (37%) | Gaps: | 226/756 - (29%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 229 AKHGNLE-----AVQELLLAEAPP----LPR--TSSGE-----------FPFDLAKEAGQTAVEE 271
Fly 272 FLLNYKLPPANTTRDQWYH--GTLTREEAVAILKKHAKELLAKQPEVDTSGCFLV--RYSESPAA 332
Fly 333 SGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSYGLPV 397
Fly 398 SLKYPVPPQPK---------PEVPSFATIPRSNMKPKAA-----------------------SPA 430
Fly 431 TPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSD- 494
Fly 495 --SESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEI 557
Fly 558 DLPPIAQKTEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSLGPNA 622
Fly 623 STESEMASY-LHRKCSGTPSTPSATEVEAAKLRF---FIEPEKLVLDREIGHGEFGSVHSG-WLL 682
Fly 683 RKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGI-AKGEMLMMVQELAPL 746
Fly 747 GSMLQYILDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMS 811
Fly 812 RSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDA 876
Fly 877 IKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYL 917 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Shark | NP_524743.2 | SH2_Nterm_shark_like | 8..91 | CDD:198210 | |
| Ank_2 | <112..184 | CDD:289560 | |||
| ANK | 117..241 | CDD:238125 | 3/16 (19%) | ||
| ANK repeat | 124..151 | CDD:293786 | |||
| ANK repeat | 153..184 | CDD:293786 | |||
| Ank_2 | 158..247 | CDD:289560 | 3/22 (14%) | ||
| ANK repeat | 186..217 | CDD:293786 | |||
| ANK repeat | 220..245 | CDD:293786 | 3/20 (15%) | ||
| Ank_4 | 224..274 | CDD:290365 | 12/66 (18%) | ||
| SH2_Cterm_shark_like | 287..395 | CDD:198211 | 18/111 (16%) | ||
| TyrKc | 662..921 | CDD:197581 | 94/258 (36%) | ||
| PTKc_Syk_like | 666..926 | CDD:270650 | 93/254 (37%) | ||
| Btk | NP_038510.2 | PH_Btk | 6..166 | CDD:269944 | 29/164 (18%) |
| Inositol-(1,3,4,5)-tetrakisphosphate 1-binding. /evidence=ECO:0000250 | 12..24 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 171..210 | 10/51 (20%) | |||
| SH3_BTK | 217..271 | CDD:212839 | 7/56 (13%) | ||
| SH2_Tec_Btk | 274..378 | CDD:198260 | 28/176 (16%) | ||
| PTKc_Btk_Bmx | 397..652 | CDD:173657 | 96/263 (37%) | ||
| Inhibitor-binding. /evidence=ECO:0000250 | 474..479 | 1/4 (25%) | |||
| CAV1-binding. /evidence=ECO:0000250 | 581..588 | 4/6 (67%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E2759_KOG0197 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.900 | |||||