DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and Blk

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_031575.2 Gene:Blk / 12143 MGIID:88169 Length:499 Species:Mus musculus


Alignment Length:585 Identity:156/585 - (26%)
Similarity:248/585 - (42%) Gaps:176/585 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   420 SNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKK--------- 475
            |.:|.:....|.||.|         |.|                :||.|...||.:         
Mouse    18 SPVKIRTQDKAPPPLP---------PLV----------------VFNHLAPPSPNQDPDEEERFV 57

  Fly   476 -ALF--------DMNSLRKNKSKGKRSDSE-----SSVSG------------------------S 502
             |||        |:..|:..|.:..||..:     |.|:|                        :
Mouse    58 VALFDYAAVNDRDLQVLKGEKLQVLRSTGDWWLARSLVTGREGYVPSNFVAPVETLEVEKWFFRT 122

  Fly   503 LAGTEQELQAAAPMLKSLSFSTEFSTFN--ADGVTGSGAAAAGEV--------------YNVPRN 551
            ::..:.|.|..|||.|:.||....|..|  |..::.......|||              |..|| 
Mouse   123 ISRKDAERQLLAPMNKAGSFLIRESESNKGAFSLSVKDITTQGEVVKHYKIRSLDNGGYYISPR- 186

  Fly   552 NTPIEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQWIGNGYQPTMDVLSLLDQQIKAPAVARLN 616
                 |..|.:    :|.|::::|.             |:|          |.|::..|.|    
Mouse   187 -----ITFPTL----QALVQHYSKK-------------GDG----------LCQKLTLPCV---- 215

  Fly   617 SLGPN---ASTESEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHS 678
            :|.|.   |..|.|                             |..:.|.|.|::|.|:||.|..
Mouse   216 NLAPKNLWAQDEWE-----------------------------IPRQSLKLVRKLGSGQFGEVWM 251

  Fly   679 GWLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQEL 743
            |:.        ::.::||||.|.:...:.:.||.||:||..|:|:.:|||..:...|.:.:|.|.
Mouse   252 GYY--------KNNMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVTREPIYIVTEY 308

  Fly   744 APLGSMLQYI-LDHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISD 807
            ...|.:|.:: .|.|..::. ..|...::|:|.||.|:|..:.:||||.|.|||::.....||:|
Mouse   309 MARGCLLDFLKTDEGSRLSL-PRLIDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIAD 372

  Fly   808 FGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEIS 872
            ||::|.:   .:||...:|.::||:|.|||:.:.|:|:..:|||||||.:.|:.:.|..||..:|
Mouse   373 FGLARII---DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGMS 434

  Fly   873 NVDAIKLVDSGERLPQPNLCPAYIY-AVMQSCWKERPKDRPTFVY----LTEFF-ARDPDYQNLP 931
            |.:.|:.::.|.|:|.|..||..:| .::..||:.||::||||.:    |.:|: |.:..|:..|
Mouse   435 NPEVIRSLEHGYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQSVLEDFYTATEGQYELQP 499

  Fly   932  931
            Mouse   500  499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211
TyrKc 662..921 CDD:197581 94/264 (36%)
PTKc_Syk_like 666..926 CDD:270650 94/266 (35%)
BlkNP_031575.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34 6/24 (25%)
SH3 56..109 CDD:302595 11/52 (21%)
SH2_Src_Blk 114..213 CDD:198234 26/131 (20%)
PKc_like 227..490 CDD:304357 98/303 (32%)
Pkinase_Tyr 235..484 CDD:285015 93/260 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0197
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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