Protein Alignment Shark and ros1

DIOPT Version :10

• Sequence 1: NP_524743.2
• Gene: Shark / 44353
• FlyBaseID: FBgn0015295
• Length: 939
• Species: Drosophila melanogaster
• Sequence 2: XP_031758565.1
• Gene: ros1 / 101733913
• XenbaseID: XB-GENE-991394
• Length: 2240
• Species: Xenopus tropicalis
• Alignment Length: 1078
• Identity: 244/1078 - (22%)
• Similarity: 376/1078 - (34%)
• Gaps: 342/1078 - (31%)

  Fly    91 YQQAANGLPTKLTVPL----------IRDLPPHN-----TRSHGVTNLLHRATSKNESKVVFELL 140
            |...|:.:|..:.|.:          |.||...|     ..|..:..:|:     .|:.:|:.||
 Frog  1199 YSMTADWIPRHIYVAVRTEQEINHIYILDLEQKNIVLKHINSSQILTILN-----IEAILVYSLL 1258

  Fly   141 ---------KCGYRNF--DAKNQDGQTALHLAALHSDEDILK----------------------- 171
                     :.|.:.|  |.||   .|..|:....:..|..|
 Frog  1259 SRLYCVESTEMGKQIFYYDIKN---DTVYHVLGHGNKTDAFKTNACSCLVDSSEIGLPIALDSTN 1320

  Fly   172 ------HLLNAKVQVNSSDSFGCQ-----PLHYAARSKPASFIRTLISAQANVQGRNIDNGYVPL 225
                  :.|.....|.:||..||.     .::....||              :.|..:|:.|:..
 Frog  1321 INNPYIYFLKNSTDVWASDLEGCHCWWVISINLLPGSK--------------ITGLAVDDYYIYW 1371

  Fly   226 HEAAKHGNLEAVQELLLAEAPPLPRTSSGEFPFDLAKEAGQTAVEEF--------LLNYKLPPAN 282
            ..|.| .|....|...|.::|.|.:...|. |..|   |..|:::.|        .||...|...
 Frog  1372 STAGK-DNATIYQASKLTKSPALLQVEQGH-PQIL---AFTTSLQPFPDKCCIVLSLNQDQPKIL 1431

  Fly   283 TTRDQWYH---------------GTLTREEAVAI--LKKHAKELLAKQPEVDTSGCFLVRYSESP 330
            |..:..:.               |:.|....|..  |::|....   :..:|.|.|.:..|.|:.
 Frog  1432 TKTNTSFTLEMTQARTQCPCPLIGSTTPTYTVKYKNLREHTNSF---ENSLDNSACTIAEYQENI 1493

  Fly   331 A-ASGL--VLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFS 392
            | ..||  ..|.:.:..::|:                  ..||...:    |:.:.:..   :..
 Frog  1494 ADILGLQPYTTYVLEVNLRNY------------------YSFLLAQE----PAAKTVTG---KTD 1533

  Fly   393 YGLP---------------VSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSP---- 438
            ||:|               |::.:..|.||...|.:......|||        .||.|.||
 Frog  1534 YGVPGAVSDITLTVWSDYAVNITWQEPAQPNGPVVAIRYQIMSNM--------LPPFPASPWRKS 1590

  Fly   439 --------------H----------SHH-----------------QHPHVPALTIT--------- 453
                          |          :.|                 |.|.||.:.:.
 Frog  1591 DFPEGLLKSAYTGLHGGTIYKFTVLAFHPDENWFTESAAVNALTFQKPSVPKIIVPGNTSLLLEW 1655

  Fly   454 KKKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAA---AP 515
            |:.|::.:...|   .|.:||:..:    :..|.|..|:|....::.|........::|.   ..
 Frog  1656 KQPQEDITDFWF---ELKNPKEEWY----VPINTSCTKKSVYMCTLIGVQPNMIYSVKAVVIFTT 1713

  Fly   516 MLKSLSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAI 580
            ..||.|.|.||.|  ..||.|..        .||:....| |...|:.:...:.:.|:......:
 Frog  1714 AAKSFSDSAEFKT--TAGVPGKP--------GVPQGKQNI-IQWMPVEEDNGSNIIYYILEYREL 1767

  Fly   581 ---ERERAGQWIG--NGYQPTMDVLSLLDQQIKAP---AVARLNSLG-PNASTESEMASYLHRK- 635
               :...:..|:.  ||..|.:.|...  .:||..   ..|..|.:| ...|..||...:..||
 Frog  1768 HDDDNNESKPWLTAYNGSCPNICVWEA--HEIKGTFEFRAAAANGIGLGEYSNTSESIIFFKRKT 1830

  Fly   636 ---------------------------------------------------------------CS 637
                                                                           |.
 Frog  1831 DVTALVAGILSGILIVLLIVAFALYWMSKQKSQKKETTAVAILEDKELMKLRGLSDAVGLANGCY 1895

  Fly   638 GTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKMLSD 702
            .....|  |:.|..||..| ..|||.|...:|.|.||.|:.|..:...|. |....:||:|.|..
 Frog  1896 AVSILP--TQKEKEKLPNF-PREKLTLCVFLGSGAFGEVYEGAAIDILGP-ETGIKKVAVKTLKR 1956

  Fly   703 EHSN--KQEFLREASVMMRLEHKCIVRLIGIAK-GEMLMMVQELAPLGSMLQYILDHGHEI---T 761
            :.::  |.|||:||.:|.:.:|..|::|:|:.. .|...::.||...|.:|.|:  .|..:   |
 Frog  1957 DATDHEKTEFLKEAHLMSQFDHPNILKLLGVCLFNEPQYIILELMDGGDLLTYL--RGARVDSFT 2019

  Fly   762 ANAELKVW-----ASQIACGMHYLESQHFVHRDLAARNILLTARHQ------AKISDFGMSRSLR 815
            .|..|...     :..|:.|..|||..|||||||||||.|::.:..      .||.|||::|.:.
 Frog  2020 QNPLLSTLDLLDISENISRGCAYLEKMHFVHRDLAARNCLVSVKEYNNPSRIVKIGDFGLARDIY 2084

  Fly   816 PGSTEYQFTQG-GRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKL 879
              ..:|....| |..|:||.||||...|||:..|||||||:.:||:|::|..||...||::.:..
 Frog  2085 --KCDYYRKNGEGLLPVRWMAPESLIDGIFTCRSDVWSFGIVLWEVFTMGQQPYPGFSNLEVLHH 2147

  Fly   880 VDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTFVYL 917
            |.||:|:..|..||..:::::|.||.:.|..||.|.:|
 Frog  2148 VQSGQRMCSPTNCPDDVWSLIQKCWAQDPWKRPAFSFL 2185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210	244/1078 (23%)
		ANKYR	<94..317	CDD:440430	55/307 (18%)
		ANK repeat	124..151	CDD:293786	8/37 (22%)
		ANK repeat	153..184	CDD:293786	6/59 (10%)
		ANK repeat	186..217	CDD:293786	5/35 (14%)
		ANK repeat	220..245	CDD:293786	6/24 (25%)
		SH2_Cterm_shark_like	287..395	CDD:198211	19/127 (15%)
		PTKc_Syk_like	666..926	CDD:270650	99/270 (37%)
ros1	XP_031758565.1	FN3	<53..>257	CDD:442628
		FN3	166..247	CDD:238020
		FN3	529..631	CDD:238020
		fn3	1037..1112	CDD:394996
		FN3	<1477..1737	CDD:442628	57/309 (18%)
		Protein Kinases, catalytic domain	1922..2190	CDD:473864	99/269 (37%)