DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Shark and tec

DIOPT Version :9

Sequence 1:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster
Sequence 2:	XP_031751261.1	Gene:	tec / 100491653	XenbaseID:	XB-GENE-6076361	Length:	648	Species:	Xenopus tropicalis

Alignment Length:	842	Identity:	199/842 - (23%)
Similarity:	307/842 - (36%)	Gaps:	259/842 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 VTNLLHRATSKNESKVVFELLKCGYRNFDAKNQDGQTALHLAALHSDEDILKHLLNAKVQVNSSD 184
            |::|:......||.:|             ..|.|         :..:|.::|         .|..
Frog     4 VSDLMFNGWKTNEQRV-------------EMNSD---------IILEESLIK---------RSQQ 37

  Fly   185 SFGCQPLHYAARSKPASFIRTLISAQANVQGR--------NIDNGYVPLHEAAKHGNLEAVQELL 241
            .....||:|    |...|:.|. |.....:||        ::|...|...|..|:|
Frog    38 KKRTSPLNY----KERVFVLTK-SRLTYYEGRPEKKNKKGSVDITKVKCVEFVKNG--------- 88

  Fly   242 LAEAPPLPRTSSGEFPFDLAKEAGQTAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHA 306
                       |...|... |.|.|...|...| |...|...:|.:|          |.::|:
Frog    89 -----------SENIPCQY-KYAFQIVYESNTL-YVFAPTAESRFKW----------VKLIKE-- 128

  Fly   307 KELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLY 371
                    ||..:...:.:|.....|.|:.  ..|.|.               .|:..|..::..
Frog   129 --------EVKNNSFIMSKYHPQFWADGVY--QCCRQT---------------EKLAPGCEEYNL 168

  Fly   372 IDD---GPYWPSVEHLIAHFMRFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPP 433
            ..|   .|..|:.:.:.|.                ||.|:|..|.    |..|.: :........
Frog   169 FGDITKKPLPPTPDAIRAR----------------PPPPRPPDPE----PEDNGE-ETVIAMFDF 212

  Fly   434 TPVSPH-------------------------SHHQHPHVPALTITKKKQKENSSSMFNTLRLTSP 473
            .||.||                         ::.|..::|:..:|:||       :.|..:
Frog   213 HPVEPHDLRLVTGEEYFVLEKKDAHWWKARNTYGQQGYIPSNYVTEKK-------LDNLYQ---- 266

  Fly   474 KKALFDMNSLRKNKSKG----KRSDSESSV---SGSLAGTEQELQAAAPMLKSLSFSTEFSTFNA 531
                ::..|...|:||.    |..|.|...   :.|.||           |.::|..|::.
Frog   267 ----YEWYSRNMNRSKAEQLLKSEDKEGGFIVRNSSQAG-----------LYTVSLYTKYG---- 312

  Fly   532 DGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERERAGQWIGNGYQPT 596
                |.|:..... |::.....|.:..|        ||...|......||..:..
Frog   313 ----GEGSTCIRH-YHIKETQYPKKYYL--------AEKHVFNTIPEMIEYHKHN---------- 354

  Fly   597 MDVLSLLDQQIKAPAVARLNSLGPNASTESEMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEK 661
                       .|..|.||.                :..||...|.|:.......|  :.|.|.:
Frog   355 -----------AAGLVTRLR----------------YPVCSKNKSAPTTAGFSYDK--WEINPSE 390

  Fly   662 LVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCI 725
            |...:|:|.|.||.|..| |         .::.:||||.:.:...::::|:.||.|||:|.|..:
Frog   391 LTFMKELGSGLFGVVRLGKW---------RAQYKVAIKAIREGAMSEEDFIEEAKVMMKLTHLKL 446

  Fly   726 VRLIGIAKGEM-LMMVQELAPLGSMLQYILD-HGHEITANAELKVWASQIAC-GMHYLESQHFVH 787
            |:|.|:...:. :.:|.|....|.:|.|:.. ||.   .:.::.:...|..| .|.|||..:|:|
Frog   447 VQLYGVCTQQRPIYIVTEFMEHGCLLNYLRQRHGQ---FSPDILLSMCQDVCEAMSYLEQNNFIH 508

  Fly   788 RDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWPIRWYAPESFNLGIFSHASDVWS 852
            |||||||.|:......|:|||||:|.:.  ..:|..:.|.::|::|..||.||...||..|||||
Frog   509 RDLAARNCLVNDAGVVKVSDFGMTRYVL--DDQYTSSCGAKFPVKWSPPEVFNYSRFSSKSDVWS 571

  Fly   853 FGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTF 914
            |||.:||:|:.|..|:...|||:.:::|..||||.:|.|....||:||.:||.|:|:.||.|
Frog   572 FGVLMWEVFTEGKMPFESYSNVEVVEMVTRGERLYRPKLATKIIYSVMVACWHEKPEGRPKF 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Shark	NP_524743.2	SH2_Nterm_shark_like	8..91	CDD:198210
		Ank_2	<112..184	CDD:289560	10/63 (16%)
		ANK	117..241	CDD:238125	24/128 (19%)
		ANK repeat	124..151	CDD:293786	3/26 (12%)
		ANK repeat	153..184	CDD:293786	4/30 (13%)
		Ank_2	158..247	CDD:289560	17/96 (18%)
		ANK repeat	186..217	CDD:293786	9/38 (24%)
		ANK repeat	220..245	CDD:293786	4/24 (17%)
		Ank_4	224..274	CDD:290365	9/49 (18%)
		SH2_Cterm_shark_like	287..395	CDD:198211	16/110 (15%)
		TyrKc	662..921	CDD:197581	98/257 (38%)
		PTKc_Syk_like	666..926	CDD:270650	97/253 (38%)
tec	XP_031751261.1	PH_Btk	27..168	CDD:269944	39/213 (18%)
		SH3_Tec	204..259	CDD:212838	7/54 (13%)
		SH2_Tec_Itk	262..368	CDD:198259	28/178 (16%)
		PTKc_Tec_Rlk	386..645	CDD:270685	100/262 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910