DRSC/TRiP Functional Genomics Resources

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Protein Alignment Shark and btk

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001123732.1 Gene:btk / 100170477 XenbaseID:XB-GENE-6451230 Length:649 Species:Xenopus tropicalis


Alignment Length:615 Identity:158/615 - (25%)
Similarity:250/615 - (40%) Gaps:159/615 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   373 DDGPYW---PSVE------HLIAHFMRFSYGLPVSLKY-------------------PVPPQPKP 409
            ||||.:   |:.|      |.:.|.:||:  ..|:.||                   .:..||..
 Frog   107 DDGPLYVFAPTEELRKRWIHQLKHVIRFN--SDVAQKYHPRFYQDGQYLCCAQTAKNAMGCQPLG 169

  Fly   410 EVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPK 474
            ....|....||..:.:  .|..||.|  ..|....|..|.|::.|                   .
 Frog   170 NANGFIRTERSQRRSR--KPLPPPPP--QESQKPLPPTPCLSLHK-------------------V 211

  Fly   475 KALFDMNSLRKNK---SKGK--------------RSDSESSVSGSLAG---TEQE--LQAAAPML 517
            .|::|...|....   .||:              |:..::.:.|.:.|   ||.:  |:......
 Frog   212 VAMYDFTPLNAQDLPLHKGEEYVLLEEGTGNPWLRARDKNGLEGYIPGNYVTEAQDPLEIYEWYS 276

  Fly   518 KSLSFSTEFSTFNADGVTGS----GAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDV 578
            |:::.|.......|:...|.    .::.||                               |..|
 Frog   277 KNMTRSQAEKLLRAEDKEGGFIVRDSSKAG-------------------------------KYTV 310

  Fly   579 AIERERAGQWI----------GNGY-------QPTMDVLSLLDQQIKAPAVARLNSLGPNASTES 626
            ::..:.:|:.|          ||.|       ..::..|....|...|..::||.          
 Frog   311 SVYAKSSGEGIIRHYVVCEAPGNQYYLAEKHLYSSIPELITYHQHNAAGLISRLK---------- 365

  Fly   627 EMASYLHRKCSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEE 690
                  :..||...:.||...:....  :.|:|:.|...:|:|:|:||.|..| |         .
 Frog   366 ------YPVCSLRKTAPSTAGLGYGS--WEIDPKDLTFLKELGNGQFGVVKYGKW---------R 413

  Fly   691 SRLEVAIKMLSDEHSNKQEFLREASVMMRLEHKCIVRLIGI-AKGEMLMMVQELAPLGSMLQYIL 754
            .:.:|||||:.:...::.||:.||..||:|.|:.:|:|.|: .|...:.::.|....|.:|.|:.
 Frog   414 GQHDVAIKMIKEGSMSEDEFIEEAKCMMKLSHQNLVQLYGVCTKQRPIFIITEFLSNGCLLNYLK 478

  Fly   755 DHGHEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGST 819
            |....: :..:|....|.:...|.||||:.::||||||||.|:.|....|:||||:||.:.  ..
 Frog   479 DLRGRV-SQGDLLSMCSDVCAAMTYLESKQYLHRDLAARNCLVAADGIVKVSDFGLSRYVL--DD 540

  Fly   820 EYQFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGE 884
            ||..:.|.::|:||.:||......||..||||||||.:||:|:||..||...:|.:.::.:..|.
 Frog   541 EYTSSLGSKFPVRWSSPEVLLYCRFSSKSDVWSFGVLMWEVFTLGRMPYDRFTNNEIVEQITRGV 605

  Fly   885 RLPQPNLCPAYIYAVMQSCWKERPKDRPTF 914
            ||.:|......:|::|.|||.|:..|||||
 Frog   606 RLYRPQNATDRVYSIMVSCWAEKADDRPTF 635

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211 10/30 (33%)
TyrKc 662..921 CDD:197581 96/255 (38%)
PTKc_Syk_like 666..926 CDD:270650 95/251 (38%)
btkNP_001123732.1 PH_Btk 8..167 CDD:269944 13/61 (21%)
SH3_BTK 209..264 CDD:212839 9/73 (12%)
SH2_Tec_Btk 267..370 CDD:198260 19/149 (13%)
PKc_like 388..638 CDD:419665 98/260 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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