DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Shark and jak3

DIOPT Version :9

Sequence 1:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster
Sequence 2:NP_001107517.1 Gene:jak3 / 100135373 XenbaseID:XB-GENE-5904698 Length:1107 Species:Xenopus tropicalis


Alignment Length:754 Identity:180/754 - (23%)
Similarity:293/754 - (38%) Gaps:174/754 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   290 HGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESPAASGLVLTLLCDQVVKNFRISQAD 354
            ||.:|.|.||..|||....:          |.|::|.|.......|:...:...:.|::|     
 Frog   379 HGPITSEFAVGKLKKSGSVV----------GSFVLRCSPQDFDKFLLTVCVETSLGKDYR----- 428

  Fly   355 LYQNGNKVQSGGSKFLYIDDGPYWPSVEHLIAHFMRFSY---GLPVSLKYPVPPQPKPEVPSFAT 416
                |..:|.....|.......::.|:..|:.|:...:.   |:...|....|||||.:  |...
 Frog   429 ----GCMIQKLNDMFSIAAVPRHFSSLWSLLEHYQHCTLSLGGVRTKLTTCCPPQPKEK--SNLL 487

  Fly   417 IPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITKKKQKENSSSMFNTLRLTSPKKALFDMN 481
            |.|.:...:...|......:...:.|: .|:..:|..:...|.:.:.:|..||....:....::.
 Frog   488 ILRDSCPQRVLLPGRERRNLQSLTFHK-IHLKDITFMESLGKGSFTKIFRGLRTDEERDERCEVE 551

  Fly   482 SLRK--NKSKGKRSDS---ESSVSGSLAGTEQELQAAAPMLKSLSFSTEFSTFNADGVTGSGAAA 541
            .|.|  :.:.|...:|   .:|:...::.....|.....:.|.:....||.           ...
 Frog   552 VLLKVLDPTYGHYQESFLEAASIMNQISHKHHILVHGVCVGKQIIMIQEFV-----------CHG 605

  Fly   542 AGEVY-NVPRNNTPIEID--LPPIAQKTEA----EVEYFTKSDVAIER---ERAGQWIGNGYQPT 596
            |.::| ...:...||.|.  |..:.|...|    |.:.....:::.::   .|.|.   .|..|.
 Frog   606 ALDLYLKRQQQKGPIAISWKLEVVRQLAYALCYLEDKQLVHGNISAKKILLSREGD---KGNPPF 667

  Fly   597 MDV------LSLLDQQIKAPAVARLNSLGP-------NASTESEMASY----------LHRKCSG 638
            :.:      :.:||:::.|   .|:..|.|       |.:.||:..|:          .|...|.
 Frog   668 IKLSDRGVSIKVLDEELLA---ERIPWLSPECVSDPNNLALESDRWSFGVTLWEIFNDGHVPLSA 729

  Fly   639 -TPST-----------PSATEVEAAKLRF-------FIEPE----------------KLVLDRE- 667
             .|||           ||...:|.|.|..       .:.|.                :|::|.: 
 Frog   730 EDPSTKLQFYNDHKTLPSPHWIELASLEQQCMSYNPLLRPSFRSIMRELNNIIAFDYELLVDSKG 794

  Fly   668 --------------------------------IGHGEFGSVHSGWLLRKSGAGEESRLEVAIKML 700
                                            :|.|.||||.   |.|....|:.:...||:|.|
 Frog   795 QQVKGGLRVCDHAWELQDPTVYEERHLKYISVLGKGNFGSVE---LCRYDPLGDNTGELVAVKKL 856

  Fly   701 SD---EHSNKQEFLREASVMMRLEHKCIVRLIGI---AKGEMLMMVQELAPLGSMLQYILDHGHE 759
            ..   ||  .::|.||:.::..|....||:..||   |......::.|..|.||:.:| |.....
 Frog   857 QHHTVEH--VRDFQRESRILRSLHSDFIVKYKGICYSAGRRSFQLIMEYLPNGSLREY-LPKNQN 918

  Fly   760 ITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFT 824
            :.....|.::||||..||.||.||.:||||||:||:|:.:|...||.|||:::.|......|...
 Frog   919 VLGPCHLLLYASQICKGMLYLGSQRYVHRDLASRNVLVESREHVKIGDFGLTKILPQDKEYYVVR 983

  Fly   825 QGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLG----APP----------YGEISNVD 875
            :.|..||.|:||||.:..|:|..||||||||.::|:|:..    :||          ..:.:...
 Frog   984 EKGESPIFWHAPESLSDSIYSRESDVWSFGVLLYELFTYSQRSCSPPTEYLRMMGPHNAQQTVCS 1048

  Fly   876 AIKLVDSGERLPQPNLCPAYIYAVMQSCWKERPKDRPTF 914
            .::.:.:|:||..|..||..:|.:|.|||...|.:||:|
 Frog  1049 LVEFLRAGKRLCTPASCPTEVYKLMLSCWSSLPSERPSF 1087

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
Ank_2 <112..184 CDD:289560
ANK 117..241 CDD:238125
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
Ank_2 158..247 CDD:289560
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786
Ank_4 224..274 CDD:290365
SH2_Cterm_shark_like 287..395 CDD:198211 22/107 (21%)
TyrKc 662..921 CDD:197581 97/306 (32%)
PTKc_Syk_like 666..926 CDD:270650 95/302 (31%)
jak3NP_001107517.1 B41 39..259 CDD:214604
FERM_B-lobe 139..250 CDD:271216
FERM_C_JAK3 255..364 CDD:275413
SH2_Jak3 364..459 CDD:198243 22/98 (22%)
PTK_Jak3_rpt1 520..779 CDD:271110 48/275 (17%)
Pkinase_Tyr 520..778 CDD:285015 48/274 (18%)
PTKc_Jak3_rpt2 816..1098 CDD:270665 95/278 (34%)
TyrKc 821..1097 CDD:197581 95/273 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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