Protein Alignment imd and Ripk1

DIOPT Version :10

• Sequence 1: NP_573394.1
• Gene: imd / 44339
• FlyBaseID: FBgn0013983
• Length: 273
• Species: Drosophila melanogaster
• Sequence 2: NP_033094.3
• Gene: Ripk1 / 19766
• MGIID: 108212
• Length: 656
• Species: Mus musculus
• Alignment Length: 191
• Identity: 50/191 - (26%)
• Similarity: 79/191 - (41%)
• Gaps: 37/191 - (19%)

  Fly    73 PNYNSM-----DVVHSANIPGTLSNVQTNNTMNVHS---AQQQVVMNFSNANNLHFGSVYNFNQN 129
            ||.:.|     ..|...||||      :..||...|   |...:.....|::.:..|   |.|..
Mouse   481 PNLSQMYSTYKTPVPETNIPG------STPTMPYFSGPVADDLIKYTIFNSSGIQIG---NHNYM 536

  Fly   130 LSACSSRKGSTSTAEESVASPDGKPRASATRKTVSIVAMMQSQEEPDVRLLDVVSTHLGEGWKQV 194
            ....:|:..:.:..|||.:.     ..:....|.|:     :.|.     |:.:..:||..||..
Mouse   537 DVGLNSQPPNNTCKEESTSR-----HQAIFDNTTSL-----TDEH-----LNPIRENLGRQWKNC 586

  Fly   195 MRDLGMSEGQIDQAIIDHQMHGNIREVIYQLLLQWIRSSADGVATVGRLTTLLWESQHRDC 255
            .|.||.:|.|||:...|::..| ::|.:||:|.:|:.......||||:|...|    |:.|
Mouse   587 ARKLGFTESQIDEIDHDYERDG-LKEKVYQMLQKWLMREGTKGATVGKLAQAL----HQCC 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
imd	NP_573394.1	Death	180..260	CDD:260017	27/76 (36%)
Ripk1	NP_033094.3	Protein Kinases, catalytic domain	23..291	CDD:473864
		Interaction with SQSTM1. /evidence=ECO:0000250|UniProtKB:Q13546	291..567		21/99 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..373
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..423
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:18442983, ECO:0000269|PubMed:27819681, ECO:0000269|PubMed:27819682	520..536		4/18 (22%)
		Death_RIP1	568..653	CDD:260048	28/85 (33%)