DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pie and PHF6

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001015877.1	Gene:	PHF6 / 84295	HGNCID:	18145	Length:	365	Species:	Homo sapiens

Alignment Length:	320	Identity:	67/320 - (20%)
Similarity:	118/320 - (36%)	Gaps:	92/320 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KELQCLICKYSDTDDLVFGEWMIVRNLQV--HYFCLLLSTHLPQRGGDSSGILGFLLRDIREEAA 67
            ::.:|..||  ...|...|:.:|..|.:|  |:.|:|.|:.|.....|:..:.||.:.|:::|..
Human    13 RQRKCGFCK--SNRDKECGQLLISENQKVAAHHKCMLFSSALVSSHSDNESLGGFSIEDVQKEIK 75

  Fly    68 AAEKRKCWYCNKIGASLQCD--RCRSLFHLKCGLENRAVFE---FCGQYKSYCYKCR-------- 119
            ...|..|..|:..||::.||  .|...:|..|.|.::|...   ..|.|..||.|.:
Human    76 RGTKLMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKAQIREKPSQGIYMVYCRKHKKTAHNSEA 140

  Fly   120 PMDD--YKRQLQSNPPRNATCPICFSSIYKVELHCVVYGDCCRLGFAHKKCMRQYALTSGYYLRC 182
            .:::  .:.:|:.:.|::                              ||..|:..
Human   141 DLEESFNEHELEPSSPKS------------------------------KKKSRKGR--------- 166

  Fly   183 IWCRSERFR---DSIRLQSVFVPDRDATWEKQRNAYREL--HERNLKCDQPNC-LCPSGRTYNRL 241
              .|...|:   :..|..|     ...|.|.:.::||:.  |..:....:|.| .|..|...|..
Human   167 --PRKTNFKGLSEDTRSTS-----SHGTDEMESSSYRDRSPHRSSPSDTRPKCGFCHVGEEENEA 224

  Fly   242 SWVILCCSSCAATSAHLKCLV---GALRL--PKKRERTDF---------------KCSMC 281
            ...:...::..| :||.||::   |.::|  ..:.|..||               ||::|
Human   225 RGKLHIFNAKKA-AAHYKCMLFSSGTVQLTTTSRAEFGDFDIKTVLQEIKRGKRMKCTLC 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600	34/114 (30%)
		PHD_SF	224..>260	CDD:304600	8/36 (22%)
		PARM	318..>491	CDD:293666
PHF6	NP_001015877.1	Nuclear localization signal. /evidence=ECO:0000255	13..16		0/2 (0%)
		Extended PHD1 domain (ePHD1). /evidence=ECO:0000255\|PROSITE-ProRule:PRU01146	14..132		35/119 (29%)
		ePHD1_PHF6	17..131	CDD:277180	34/115 (30%)
		Nuclear localization signal. /evidence=ECO:0000255	129..133		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..211		14/117 (12%)
		Nucleolar localization signal. /evidence=ECO:0000255	157..169		3/52 (6%)
		Extended PHD2 domain (ePHD2). /evidence=ECO:0000255\|PROSITE-ProRule:PRU01146	209..330		18/76 (24%)
		ePHD2_PHF6	212..329	CDD:277181	17/73 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..365
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12420
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.870