DRSC/TRiP Functional Genomics Resources

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Protein Alignment pie and Kmt2b

DIOPT Version :9

Sequence 1:NP_001260348.1 Gene:pie / 44315 FlyBaseID:FBgn0005683 Length:582 Species:Drosophila melanogaster
Sequence 2:NP_001277502.1 Gene:Kmt2b / 75410 MGIID:109565 Length:2722 Species:Mus musculus


Alignment Length:531 Identity:109/531 - (20%)
Similarity:161/531 - (30%) Gaps:189/531 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 QCLIC-KYSDTDDLVFGEWMIV-RNLQVHYFCLLLSTHLPQRGGDSSGILGFLLRDIREEAAAAE 70
            ||.:| ||.|.|....|..:.: :|...|..|.:.|..:.:....|       |:::....|...
Mouse  1586 QCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGS-------LKNVHAAVARGR 1643

  Fly    71 KRKCWYCNKIGASLQC--DRCRSLFHLKCGLENRAVFEFCGQYKSYCYKCRPMDDYKRQLQSNPP 133
            :.:|..|.|.||::.|  ..|.|.||..|...:..:|:  ...|.:|.|...:.|.|        
Mouse  1644 QMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQ--DDKKVFCQKHTDLLDGK-------- 1698

  Fly   134 RNATCPICFSSIYKVELHCVVYGDCCRLGFAHKKCMRQYALTSGYYLRCIWCRSERFRDSIRLQS 198
             ....|..|..:.:      ||.|...:.|..|       ..:|.....|    .....|||:.|
Mouse  1699 -EIVTPDGFDVLRR------VYVDFEGINFKRK-------FLTGLEPDVI----NVLIGSIRINS 1745

  Fly   199 VFVPDRDATWEKQRNAYRELHERNLKCDQPNC---LCPSGRTYNRLSWVILCCSSCAATSAHLKC 260
            :                      ....|..:|   |.|.|...:||.|        :...|..:|
Mouse  1746 L----------------------GTLSDLSDCEGRLFPIGYQCSRLYW--------STVDARRRC 1780

  Fly   261 LVGALRLPKKRERTDFKCSMCLDVERRIAEGPARTTEETNADGDNQVDGSFYVQKLGPDAATRSL 325
            .              ::|        ||.|                      .:..||       
Mouse  1781 W--------------YRC--------RILE----------------------YRPWGP------- 1794

  Fly   326 TQTPVFSEEDESERSSNITVIFSQPKSNATSERLSLSPPQEEMIVEIPDSPEASPKTSIDENHSP 390
            .:.||..|..|    .|.|::.|...|:        .||..:   ::||:....|...:  :|||
Mouse  1795 REEPVHLEAAE----ENQTIVHSPTPSS--------EPPNHD---DLPDTDSLIPGDPV--HHSP 1842

  Fly   391 ----QPIARRDTSDSPQPIAAS------EIPD-------------SPQPTAAS------EIPDL- 425
                .|..|.|:|:.|.|...|      ::|:             .|.|:..|      .||.: 
Mouse  1843 IQNLDPPLRTDSSNGPPPTPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVG 1907

  Fly   426 -------------PQTTAINVNPELTQQTALNTIPHSPQPEASFSTQLVSQTFDCPQPQEQAVAK 477
                         |...|....|.....:.|.|   |||.....||.:.:.|   |...|.|...
Mouse  1908 DSDFPAPPRRSRRPSPLATRPPPSRRTSSPLRT---SPQLRVPLSTSVTALT---PTSGELAPPD 1966

  Fly   478 APNSPSLPKED 488
            ...||..|.||
Mouse  1967 LAPSPLPPSED 1977

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pieNP_001260348.1 PHD_SF 9..117 CDD:304600 28/111 (25%)
PHD_SF 224..>260 CDD:304600 9/38 (24%)
PARM 318..>491 CDD:293666 49/214 (23%)
Kmt2bNP_001277502.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..65
Menin-binding motif (MBM). /evidence=ECO:0000250|UniProtKB:Q9UMN6 17..36
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 82..524
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 542..783
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 831..872
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 899..964
zf-CXXC 963..1010 CDD:251032
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1032..1076
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1088..1138
PHD1_KMT2B 1209..1255 CDD:277064
PHD2_KMT2B 1257..1306 CDD:277066
PHD3_KMT2B 1343..1399 CDD:277068
Bromo_ALL-1 1380..1522 CDD:99925
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1550..1572
ePHD_KMT2B 1587..1691 CDD:277164 28/112 (25%)
FYRN 1740..1786 CDD:283589 15/97 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2065..2113
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2125..2169
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2288..2365
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2391..2417
FYRC 2420..2504 CDD:197781
WDR5 interaction motif (WIN). /evidence=ECO:0000250|UniProtKB:Q9UMN6 2515..2520
SET <2566..2722 CDD:225491
SET 2584..2704 CDD:214614
S-adenosyl-L-methionine binding. /evidence=ECO:0000250|UniProtKB:Q03164 2659..2660
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1084
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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