DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pie and Phf6

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_081918.1	Gene:	Phf6 / 70998	MGIID:	1918248	Length:	364	Species:	Mus musculus

Alignment Length:	318	Identity:	69/318 - (21%)
Similarity:	118/318 - (37%)	Gaps:	88/318 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KELQCLICKYSDTDDLVFGEWMIVRNLQV--HYFCLLLSTHLPQRGGDSSGILGFLLRDIREEAA 67
            ::.:|..||  ...|...|:.:|..|.:|  |:.|:|.|:.|.....|:..:.||.:.|:::|..
Mouse    13 RQRKCGFCK--SNRDKECGQLLISENQKVAAHHKCMLFSSALVSSHSDNESLGGFSIEDVQKEIK 75

  Fly    68 AAEKRKCWYCNKIGASLQCD--RCRSLFHLKCGLENRAVFEFCGQYKSYCYKCRPMDDYKRQLQS 130
            ...|..|..|:..||::.||  .|...:|..|.|.::|                       |::.
Mouse    76 RGTKLMCSLCHCPGATIGCDVKTCHRTYHYHCALHDKA-----------------------QIRE 117

  Fly   131 NPPRNATCPICFSSIYKVELHCVVYGDCCRLGFAHKKCMR--QYALTSGYYLRCIWCRSERFRDS 193
            .|.:         .||      :||   ||   .|||...  :..|...:....:...|.:.:..
Mouse   118 KPSQ---------GIY------MVY---CR---KHKKTAHNSEADLEESFNEHELEPSSPKTKKK 161

  Fly   194 IR--------LQSVFVPDRD----ATWEKQRNAYREL--HERNLKCDQPNC-LCPSGRTYNRLSW 243
            .|        |:.:....|.    .|.|.:.::||:.  |..:....:|.| .|..|...|....
Mouse   162 SRKGRPRKTNLKGLPEDSRSTSSHGTDEMESSSYRDRSPHRSSPNDTRPKCGFCHVGEEENEARG 226

  Fly   244 VILCCSSCAATSAHLKCLV---GALRL--PKKRERTDF---------------KCSMC 281
            .:...::..| :||.||::   |.::|  ..:.|..||               ||::|
Mouse   227 KLHIFNAKKA-AAHYKCMLFSSGTVQLTTTSRAEFGDFDIKTVLQEIKRGKRMKCTLC 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600	30/111 (27%)
		PHD_SF	224..>260	CDD:304600	8/36 (22%)
		PARM	318..>491	CDD:293666
Phf6	NP_081918.1	Nuclear localization signal. /evidence=ECO:0000255	13..16		0/2 (0%)
		Extended PHD1 domain (ePHD1). /evidence=ECO:0000255\|PROSITE-ProRule:PRU01146	14..132		38/163 (23%)
		ePHD1_PHF6	17..131	CDD:277180	38/159 (24%)
		Nuclear localization signal. /evidence=ECO:0000255	129..133		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..211		10/71 (14%)
		Nucleolar localization signal. /evidence=ECO:0000255	157..169		1/11 (9%)
		Extended PHD2 domain (ePHD2). /evidence=ECO:0000255\|PROSITE-ProRule:PRU01146	209..330		18/76 (24%)
		ePHD2_PHF6	212..329	CDD:277181	17/73 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..364
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12420
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870