DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pie and kdm4c

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001077320.1	Gene:	kdm4c / 570194	ZFINID:	ZDB-GENE-070209-38	Length:	1482	Species:	Danio rerio

Alignment Length:	687	Identity:	128/687 - (18%)
Similarity:	210/687 - (30%)	Gaps:	226/687 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NKELQCLICKYSDTDDLVFGEWMIVRNLQVHYFCLLLSTHLPQRGGDSSGILGFLLRDIREEAAA 68
            |.::.| ..:|.:.:||....|   :||      ..:|   |..|.|.||.|  ...||.|
Zfish   104 NSDMYC-TPRYLNYEDLERKYW---KNL------TFVS---PIYGADVSGTL--YDEDIEE---- 149

  Fly    69 AEKRKCWYCNKIGASLQCDRCRSLFHLKCGLENRAV---FEFCGQYK-SYCYKCRPMDDYK---- 125
                  |....:.:.|      .:....||:..:.|   :.:.|.:| |:.:....||.|.
Zfish   150 ------WNIGHLNSVL------DVIEEDCGVSIQGVNTPYLYFGMWKTSFSWHTEDMDLYSINYL 202

  Fly   126 -----RQLQSNPPRNAT---------CPICFSSIYKVELHCVVYGDCCRLGFAHK------KCMR 170
                 :...:.||.:..         .|..|.|              |.....||      ..::
Zfish   203 HFGEPKSWYAIPPEHGKRLERLAIGFFPNSFKS--------------CEAFLRHKMTLISPSVLK 253

  Fly   171 QYAL----------------TSGYY------LRCIWCRSERF------------------RDSIR 195
            :|::                ..||:      ..|  ..|..|                  :|.::
Zfish   254 KYSIPFDKITQEAGEFMITFPYGYHAGFNHGFNC--AESTNFASIRWIDYGKLATQCTCSKDMVK 316

  Fly   196 LQ-----SVFVPDRDATWEKQRNAYRELHERNLKCDQPNCLCPSGRTYNRLSWVILCCSSCAATS 255
            :.     ..|.|||...|.:.:::          |...:.|.....|....||:........:||
Zfish   317 ISMDPFVRRFQPDRYELWTQGKDS----------CSLDHTLPTPSTTPELQSWLQRRRRKTPSTS 371

  Fly   256 AHLKCLVGALRLPKKRERTDFKCSMCLDVER-RIAEGPARTTEETNADGDNQVDGSFYVQKLGPD 319
            .|      |.|...||.:|.....:.....| |.|...|:..||...|.......|.|..:| ..
Zfish   372 LH------APRSCSKRLKTVDSAPVKGSGRRSRSAALTAKNKEEEEEDPVKHQKESQYSSEL-KG 429

  Fly   320 AATRSLTQTPVFSEEDESERSSNITVIFSQPKSNATSERLSLSPPQEEMIVEIPDSPEASPKTS- 383
            .|.|.:....|...|.:....|...|..:.|:...|....:.|...:      ||....|.:||
Zfish   430 LAGRQMCVVKVTRVESDLLAQSTRQVKEASPERLLTPTLTTTSSQND------PDVGHTSSQTSL 488

  Fly   384 -IDENHSPQPIARRDTSDSPQPIAASEIPDSPQPTAASE-IPDL---PQTTAINVNPELTQQTAL 443
             :||..     ..::|:.:.|        ..|:.|:.|: |.|:   .:.||.|.|..|..::.|
Zfish   489 ILDEGQ-----VSKNTNSTAQ--------SEPESTSESDIIVDVTLGSERTAKNPNQTLNCESVL 540

  Fly   444 NTI---------------------PHSPQPEASFSTQ------LVSQTFDCPQPQEQAVAKAPNS 481
            .||                     ..|...:|...|:      |...:.||   ...|:.|..:|
Zfish   541 ETIAPSIPVTHSLTLHSTGATVLFSESDSQQAKIETEETVIDTLTEDSIDC---GTSALYKEQSS 602

  Fly   482 ----PSLPKEDPNTLLVLKSGFQCPGEPFFYL------VIYEFEHGTCMGECIGTCVLRFKEDDP 536
                |:|...:|:   :.::..:....||..:      :|.|..:..|:...:.:..|..:.|..
Zfish   603 ISLDPALQGSEPS---MNRTNSEIQTTPFCEMPLLMPELIEERVNPQCLAPEMPSLTLAIRPDSA 664

  Fly   537 RIQDTSQAALERVNITPDDVWCRSEDRGIFEHIEKFH 573
            ..|..:.|.:                    .|:||.|
Zfish   665 NHQPYNSAPI--------------------LHLEKSH 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600	25/111 (23%)
		PHD_SF	224..>260	CDD:304600	8/35 (23%)
		PARM	318..>491	CDD:293666	43/209 (21%)
kdm4c	NP_001077320.1	JmjN	16..57	CDD:128818
		JmjC	177..293	CDD:202224	19/131 (15%)
		PHD_SF	1079..1176	CDD:304600
		ePHD_JMJD2C	1185..1294	CDD:277185
		TUDOR	1308..1364	CDD:197660
		TUDOR	1366..1421	CDD:197660
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910