DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pie and nedd4l

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_021324687.1	Gene:	nedd4l / 559634	ZFINID:	ZDB-GENE-051118-2	Length:	1279	Species:	Danio rerio

Alignment Length:	353	Identity:	74/353 - (20%)
Similarity:	107/353 - (30%)	Gaps:	136/353 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 GPDAATRSLTQTPVFSEEDESERSSNITVIFSQPKSNATSERLSLSPPQEEMIVEIPDSPEASPK 381
            ||.:....|:.||.||:|                    .|.||||:|....   ||| .|.::.:
Zfish   570 GPSSLAMPLSSTPDFSDE--------------------ISLRLSLAPDTNG---EIP-GPSSAVQ 610

  Fly   382 TSI--------------DENHSPQPIARRDTSDS-PQPIAASEIPDSPQPTAASEIPDLP----- 426
            :.:              |:...|.|.....|..: .|.:...|...||..:.|...|.||
Zfish   611 SHLSSRLRSSSMTDGVSDQAQPPTPTQSSQTRRTRAQTVTGVEDTMSPSASYALTTPGLPPGWEE 675

  Fly   427 ------QTTAINVN--------PELTQQT-------------ALNTIP----------HSPQPEA 454
                  :|..:|.|        |.|.|.|             |....|          |..:|:.
Zfish   676 RKDPKGRTYYVNHNNRSTTWTRPILQQHTEDGASTSVAAVGGATAATPPASTPSTSSGHLSEPQV 740

  Fly   455 SFSTQLVSQTFDCPQPQEQA----VAKA-------PNSPS-LPKEDPNTLLVLKSGFQCP----- 502
            .....|.|.|.....|.|.|    :.:|       |.||. .|...|.|.......|..|
Zfish   741 RRPRSLSSPTVTLSSPLEGANNVPIRRAVKDTFSNPQSPQPSPYSSPKTQHKANQSFLPPGWEMR 805

  Fly   503 ----GEPFFYLVIYEFEHG--TCMGECIGTCVLRFKEDDPR----IQDTSQAALERVNITP---- 553
                |.|||      .:|.  |...|            |||    :...::|:|:..::.|
Zfish   806 IAPNGRPFF------IDHNSRTTTWE------------DPRLKYPVHMRTKASLDPGDLGPLPNL 852

  Fly   554 --DDVW---CRSEDRGIF-EHIEKFHEW 575
              :..|   ..::.|..: :|..|..:|
Zfish   853 PEEPGWEERVHADGRTFYIDHNNKKTQW 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600
		PHD_SF	224..>260	CDD:304600
		PARM	318..>491	CDD:293666	52/241 (22%)
nedd4l	XP_021324687.1	C2	<374..430	CDD:326325
		WW	473..499	CDD:306827
		WW	669..698	CDD:306827	5/28 (18%)
		WW	798..829	CDD:197736	10/48 (21%)
		WW	856..885	CDD:238122	5/25 (20%)
		HECTc	946..1275	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910