DRSC/TRiP Functional Genomics Resources

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Protein Alignment pie and kmt2a

DIOPT Version :9

Sequence 1:NP_001260348.1 Gene:pie / 44315 FlyBaseID:FBgn0005683 Length:582 Species:Drosophila melanogaster
Sequence 2:XP_005157640.1 Gene:kmt2a / 557048 ZFINID:ZDB-GENE-080521-3 Length:4219 Species:Danio rerio


Alignment Length:621 Identity:128/621 - (20%)
Similarity:204/621 - (32%) Gaps:199/621 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DNKELQCLIC-KYSD--TDD----LVFG--EWMIVRNLQVHYFCLLLSTHLPQRGGDSSGILGFL 58
            ||:  ||.:| .|.|  |:|    |..|  ||       .|..|.|.|..:.:   |..|    .
Zfish  2064 DNR--QCALCLNYGDEKTNDCGRLLYIGHNEW-------AHVNCALWSAEVYE---DVDG----A 2112

  Fly    59 LRDIREEAAAAEKRKCWYCNKIGASLQC--DRCRSLFHLKCGLENRAVF-----EFCGQYK---- 112
            |:::....:..::.:|..|:|.||::.|  ..|.:.:|..|..:.:..|     .:|..:|    
Zfish  2113 LKNVHMAVSRGKQLQCKNCHKPGATVSCCMTSCTNNYHFMCARQQQCAFLEDKKVYCQHHKDLVK 2177

  Fly   113 -------SYCYKCRPMDDY------KRQLQSNPPRNATCPICFSSIYKVELHCVV---------- 154
                   |:....|.:.|:      ::.:....|.|              :|.|:          
Zfish  2178 GEVVPESSFEVTRRVLVDFEGIRLRRKFVNGLEPDN--------------IHMVIGSMTIDCLGM 2228

  Fly   155 ---YGDCCR----LGFAHKKCMRQYALTSGYYLRCIW------CR---SERFRDSIRLQ------ 197
               ..||.|    :|:   :|.|.|..|.....||::      ||   ||....:|..|      
Zfish  2229 LTELSDCERKLFPVGY---QCSRVYWSTLDARKRCVYKCRILVCRPPLSETLNKNIAAQEENHTV 2290

  Fly   198 ----------SVFVPDR-DAT-------WEKQRNAYRELHERNLKCDQ-PNCL-CPSGRTYNRLS 242
                      ..|:|.. |:|       ..|.|..:|..|.....|.: |:.. .||...:|...
Zfish  2291 VHSPPPVSAVDTFLPGPIDSTKPSNVPSTPKPRVYFRNRHPSFPPCHRSPSTRPLPSPDGFNNTG 2355

  Fly   243 WVILCCSSCAATSAHLKCLVGALR-LPKKRERTDFKCSMCLDVERRIAEGPARTTEETNADGDNQ 306
            ..|:....        ..|..:|| :..:|..|.   |:.....|:....|.:            
Zfish  2356 HEIVTVGD--------PLLSSSLRSIGSRRHSTS---SISAQQPRQKVSSPPQ------------ 2397

  Fly   307 VDGSFYVQKLGPDAATRSLT-QTPVFSEEDESERSSNITVIFSQPKS--NATSERLSLSPPQEEM 368
             .|:.|.|.....|:..|.| :.|:..:.|:...||..|....:|.|  .....|||..     .
Zfish  2398 -GGTVYSQTGNSSASFMSSTSKEPLTKDTDKGRVSSGETSFSREPNSINIGAQRRLSFG-----F 2456

  Fly   369 IVEIPDSPEASPKTSIDEN-HSPQPIA----------------------------RRDTSDSPQP 404
            ...:..|.||:.|.|..|: .|.||.:                            ::.|.|:..|
Zfish  2457 TERVDGSKEATKKHSDGESLKSSQPASVSQVSPPLGTAVLTGHQRASGGIKNEKGKQATKDNDLP 2521

  Fly   405 IAASEIPDSPQPTAASEIPDLPQTTAINVNPE--LTQQTALNTIPHSPQPEASFSTQLVSQTFDC 467
            ..|:.:...|       :..||:..| |.|.|  :|...||.....:..|:..::.....::.|.
Zfish  2522 AGATFMSSHP-------LAMLPKDKA-NPNKEGNMTSMAALKDTVKTGSPQRIYNKSGSRKSHDY 2578

  Fly   468 PQPQEQAVAKAP---NSPSLPKEDPNTLLVLKSGFQ 500
            .......||..|   :...|.:||      :|.|||
Zfish  2579 ASGPAAVVAMKPLWSSGAKLGEED------IKRGFQ 2608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pieNP_001260348.1 PHD_SF 9..117 CDD:304600 30/134 (22%)
PHD_SF 224..>260 CDD:304600 6/37 (16%)
PARM 318..>491 CDD:293666 44/209 (21%)
kmt2aXP_005157640.1 zf-CXXC 1312..1359 CDD:251032
PHD1_KMT2A 1627..1673 CDD:277063
PHD2_KMT2A 1675..1724 CDD:277065
PHD3_KMT2A 1762..1818 CDD:277067
Bromo_ALL-1 1841..1971 CDD:99925
ePHD_KMT2A 2066..2178 CDD:277163 30/127 (24%)
FYRN 2220..2266 CDD:283589 10/48 (21%)
FYRC 3919..4002 CDD:197781
SET <4060..4219 CDD:225491
SET 4081..4201 CDD:214614
PostSET 4203..4219 CDD:214703
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1084
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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