DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pie and G2E3

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_060239.2	Gene:	G2E3 / 55632	HGNCID:	20338	Length:	706	Species:	Homo sapiens

Alignment Length:	296	Identity:	97/296 - (32%)
Similarity:	156/296 - (52%)	Gaps:	35/296 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DNKELQCLICKYSDTDDLVFGE------WMIVRNLQVHYFCLLLSTHLPQRGGDSSGILGFLLRD 61
            |::.|.|:.|:..|.....:||      |    ||.|||:|||:|:.:.|||.:..|:.|||:.|
Human     8 DSQNLACVFCRKHDDCPNKYGEKKTKEKW----NLTVHYYCLLMSSGIWQRGKEEEGVYGFLIED 68

  Fly    62 IREEAAAAEKRKCWYCNKIGASLQC--DRCRSLFHLKCGLENRAVFEFCGQYKSYCYKCRPM--- 121
            ||:|...|.|.||..|.|.|||:.|  .||:..:|..|||:...:|:|.|.:.|:|:..||:
Human    69 IRKEVNRASKLKCCVCKKNGASIGCVAPRCKRSYHFPCGLQRECIFQFTGNFASFCWDHRPVQII 133

  Fly   122 --DDYKRQLQSNPPRNATCPICFSSIYKVELHCVVYGDCCRLGFAHKKCMRQYALTSG-YYLRCI 183
              ::|:..|        .|.||...|..:..:.::...||:..:.|:.|::..|:.:| ::.||.
Human   134 TSNNYRESL--------PCTICLEFIEPIPSYNILRSPCCKNAWFHRDCLQVQAINAGVFFFRCT 190

  Fly   184 WC-RSERFRDSIRLQSVFVPDRDATWEKQRNAYRELHERNLKCDQPNCLCPSGRTYNR--LSWVI 245
            .| .|:.|:..:....:.:|::||:||.:.|||:||.:...:||...|.|..||.||.  ..|.|
Human   191 ICNNSDIFQKEMLRMGIHIPEKDASWELEENAYQELLQHYERCDVRRCRCKEGRDYNAPDSKWEI 255

  Fly   246 LCCSSCAATSAHLKCLVGALRLPKKRERTDFKCSMC 281
            ..|..|.::..||.|  .:||..::    :::|..|
Human   256 KRCQCCGSSGTHLAC--SSLRSWEQ----NWECLEC 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600	47/115 (41%)
		PHD_SF	224..>260	CDD:304600	14/37 (38%)
		PARM	318..>491	CDD:293666
G2E3	NP_060239.2	ePHD_PHF7_G2E3_like	14..127	CDD:277139	47/116 (41%)
		PHD_PHF7_G2E3_like	232..285	CDD:276971	18/58 (31%)
		HECTc	411..692	CDD:331829
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141433
Domainoid	1	1.000	93	1.000	Domainoid score	I7551
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110264at33208
OrthoFinder	1	1.000	-	-		FOG0003998
OrthoInspector	1	1.000	-	-		otm41254
orthoMCL	1	0.900	-	-		OOG6_106451
Panther	1	1.100	-	-	O	PTHR12420
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3283
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.750