DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pie and PHF11

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001035533.1	Gene:	PHF11 / 51131	HGNCID:	17024	Length:	331	Species:	Homo sapiens

Alignment Length:	171	Identity:	40/171 - (23%)
Similarity:	63/171 - (36%)	Gaps:	45/171 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EDNKELQCLIC-KYSDTDDLVFGEWMIVRNLQVHYFCLLLSTHL----------PQRGGDSSGIL 55
            |..::..|.:| |..:.:.|.|.:   ..|:..|..|||.|:.|          |.|..|
Human    38 EKMEKRTCALCPKDVEYNVLYFAQ---SENIAAHENCLLYSSGLVECEDQDPLNPDRSFD----- 94

  Fly    56 GFLLRDIREEAAAAEKRKCWYCNKIGASLQCD--RCRSLFHLKCGLENRAVFEFCGQYKSYCYKC 118
               :..:::|.....|.||.:|:|.||::.||  .|...:|..|..::.||.:..|....|...|
Human    95 ---VESVKKEIQRGRKLKCKFCHKRGATVGCDLKNCNKNYHFFCAKKDDAVPQSDGVRGIYKLLC 156

  Fly   119 RPMDDY------------------KRQLQSN---PPRNATC 138
            :....:                  |:.|..|   ||....|
Human   157 QQHAQFPIIAQSAKFSGVKRKRGRKKPLSGNHVQPPETMKC 197

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600	32/120 (27%)
		PHD_SF	224..>260	CDD:304600
		PARM	318..>491	CDD:293666
PHF11	NP_001035533.1	ePHD_PHF11	45..159	CDD:277182	33/124 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12420
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.870