DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pie and arel1

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001011393.1	Gene:	arel1 / 496863	XenbaseID:	XB-GENE-5852856	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	423	Identity:	78/423 - (18%)
Similarity:	131/423 - (30%)	Gaps:	118/423 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 VILCCSSCAATSAHLK-----CLVGALR---LPKKRERTDFKCSMCLDVERRIAEGPARTTEETN 300
            |.:|..|......||.     |....||   ||  ....:|:..:..|.|:.|.
Frog   228 VSVCSGSQNRVLLHLALLQTGCFQATLRFQGLP--INNGNFQIIVLTDGEKTIV----------- 279

  Fly   301 ADGDNQVD----GSFYVQKLGPDAATRSLT---QTPVFSEEDESERSSNITVIFSQPKS---NAT 355
               ||.|.    |.|:...|.|.:::.::.   ::...|.::||....:......:||.   ..|
Frog   280 ---DNNVSRSGVGVFFEGYLYPPSSSPNIPGQHRSSSTSNDEESNADGHTVDRLKKPKKVYFYIT 341

  Fly   356 SERLSLSP----------------PQEEMIVEIPDSPEASPKTSIDENHSPQPI----------A 394
            .::||:..                |..:.:...||.........:|:...| ||          |
Frog   342 PKQLSVKEFYLRIIPWRLFTFRVCPGTKFLYLPPDPLHGLLSLQVDDGLQP-PIEISCKDRNIMA 405

  Fly   395 RRDTSDSPQPIAASEIPDSPQPTAASEIPDLP-QTTAINVNPELTQQTALNTIPHSPQPEASFST 458
            ...|......|..||...........|:..:. :.|...|..::.:.:.|.:   |.:...:||.
Frog   406 ATFTRFLHLNIGGSETFQDKVTFFQKELRQIHCKKTRCKVTLKVNRHSLLES---SLRATRNFSA 467

  Fly   459 QLVSQTFDCPQPQEQAVAKAPNSPSLPKE-----------DPNTLLVLK-----SGFQCPG---E 504
            ....:.|:.....|:|:....     |:.           |.|..|.::     .|...|.   .
Frog   468 SDWCKNFEVVFQDEEALDWGG-----PRREWFELICKTLFDTNNQLFIRFSDSNQGLVHPNPCRP 527

  Fly   505 PFFYLVIYEFEHGTCMGECI------GTCV-----------------LR-----FKEDDPRIQDT 541
            |...:.:|||. |..:|:|:      |.|.                 ||     |:.|||....|
Frog   528 PNIRVKLYEFA-GRVVGKCLFESSLGGGCEQLVRARFTRSFLAQIIGLRMHYKYFETDDPDFFQT 591

  Fly   542 SQAALERVNITPDDVWCRSEDRGIFEHIEKFHE 574
            ....:...::...::....|..|....:||..|
Frog   592 KVQYILTNDVIDTELSFAEEKYGRAGQLEKVVE 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600
		PHD_SF	224..>260	CDD:304600	5/20 (25%)
		PARM	318..>491	CDD:293666	33/216 (15%)
arel1	NP_001011393.1	Filamin	56..153	CDD:366210
arel1	NP_001011393.1	HECTc	447..804	CDD:238033	34/187 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910