DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pie and trx

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_476769.1	Gene:	trx / 41737	FlyBaseID:	FBgn0003862	Length:	3726	Species:	Drosophila melanogaster

Alignment Length:	469	Identity:	83/469 - (17%)
Similarity:	151/469 - (32%)	Gaps:	130/469 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CLICKYSDTDDLVFGEWMIVRNLQVHYFCLLLSTHLPQRGGDSSGILGFLLRDIREEAAAAEK-- 71
            |.:|..:..|.|:|......   ..|.:|:....:|.....:.:.::|.||......:.....
  Fly  1269 CFLCGSTGLDPLIFCACCCE---PYHQYCVQDEYNLKHGSFEDTTLMGSLLETTVNASTGPSSSL 1330

  Fly    72 --------------RKCWYCN-KIGASLQCDRCRSLFHLKC--------GLENRAVFEFCGQYKS 113
                          ..|:.|| ..|:.::|.:|:..:|..|        |.:...:...|.:.||
  Fly  1331 NQLTQRLNWLCPRCTVCYTCNMSSGSKVKCQKCQKNYHSTCLGTSKRLLGADRPLICVNCLKCKS 1395

  Fly   114 Y-----------------CYKCRPMDDYKRQLQSNPPRNATCPICFSSIY---KVELHCVVYGDC 158
            .                 |:|.|...::             |||| ...|   ..:|..:..|||
  Fly  1396 CSTTKVSKFVGNLPMCTGCFKLRKKGNF-------------CPIC-QRCYDDNDFDLKMMECGDC 1446

  Fly   159 CRLGFAHKKCM----RQYALTSGY--YLRCIWCRSERFRDSIRLQSVFVPDRDATWEKQRNAYRE 217
            .:  :.|.||.    .||.|.|..  .:..|..:..|..:|.::::          |:.|.|..|
  Fly  1447 GQ--WVHSKCEGLSDEQYNLLSTLPESIEFICKKCARRNESSKIKA----------EEWRQAVME 1499

  Fly   218 LHERNLKCDQPNCLCPSGRTYNRLSWVILCCSSCA----ATSAHLKCLVGALRLPKKRERTDFKC 278
            ..:.:|              |:.|..:.....:||    :....|:|..||.....|.:....:.
  Fly  1500 EFKASL--------------YSVLKLLSKSRQACALLKLSPRKKLRCTCGASSNQGKLQPKALQF 1550

  Fly   279 SMCLDVERRIAEGPARTTEETNADGDNQVDGSFYVQKLGPDAATRSLTQTPVFSEEDESERSSNI 343
            |                     :..||         .||.|..:::......|.::.:.::..|.
  Fly  1551 S---------------------SGSDN---------GLGSDGESQNSDDVYEFKDQQQQQQQRNA 1585

  Fly   344 TVIFSQPKSNATSERLSLSPPQEEMIVEIPDSPEASPKTSIDE-NHSPQPIARRDTSDSPQPIAA 407
            .:...:.||...|.:..:|..|...:|:|......:...|:.| |:....:.::...|. ..||.
  Fly  1586 NMNKPRVKSLPCSCQQHISHSQSFSLVDIKQKIAGNSYVSLAEFNYDMSQVIQQSNCDE-LDIAY 1649

  Fly   408 SEIPDSPQPTAASE 421
            .|:.....|...:|
  Fly  1650 KELLSEQFPWFQNE 1663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600	24/149 (16%)
		PHD_SF	224..>260	CDD:304600	5/39 (13%)
		PARM	318..>491	CDD:293666	19/105 (18%)
trx	NP_476769.1	NR_DBD_like	762..>856	CDD:295381
		PHD1_KMT2A_like	1268..1344	CDD:276981	11/77 (14%)
		PHD	1346..1390	CDD:214584	9/43 (21%)
		PHD3_KMT2A_like	1423..1479	CDD:276983	17/71 (24%)
		ePHD_KMT2A_like	1737..1841	CDD:277134
		FYRN	1891..1935	CDD:283589
		FYRC	3388..3476	CDD:197781
		SET	3590..3710	CDD:214614
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810