DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pie and Nedd4

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_648993.1	Gene:	Nedd4 / 39958	FlyBaseID:	FBgn0259174	Length:	1007	Species:	Drosophila melanogaster

Alignment Length:	434	Identity:	79/434 - (18%)
Similarity:	135/434 - (31%)	Gaps:	159/434 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   206 ATWEKQRNAYRELHERNLKCDQPNCLCPSGRTY------NRLSW---VILCCSSCAATSAHLKCL 261
            |.||::::|                   :||||      ....|   .:|...|..:|...|
  Fly   250 AGWEERQDA-------------------NGRTYYVNHTARTTQWDRPTVLNSHSSQSTDDQL--- 292

  Fly   262 VGALRLPKKRERTDFKCSMCLDVERRIAEGPARTTEETNADGDNQVDGSFYVQKLGPDAATRSL- 325
                       .:||:....:.|:...:...|.:....:.:.:|...|..|..|   .|||.|.
  Fly   293 -----------ASDFQRRFHISVDDTESGRSADSISHNSIEDNNNAAGLAYTPK---TAATSSAP 343

  Fly   326 TQTPV-------------FSEEDESERSSNITVIFS---------QPKSNATSERLSLSPPQEEM 368
            ..||.             .:|||:.....:.:.:::         ||:.:|||.:..|.|.:|
  Fly   344 PNTPTNNNGILAQIAMQYRAEEDQDPTVDHTSFVYNSLRHPVAHRQPEISATSLQNDLRPVRE-- 406

  Fly   369 IVEIPDSPEASPKTS-----------------------------------------IDENH---S 389
            ...:||....:|.|.                                         :|.:|   .
  Fly   407 APGVPDIAITNPFTRRAAGNMAGGAGWQQERRRQQMQLHIQQHQQRQQQQQQNRILLDVDHRQQE 471

  Fly   390 PQPIARR------------DTSDSPQP---IAASEIPDSPQPTAASEIPDLPQTTAINVNPELTQ 439
            ||...:|            |.:||..|   .|.|...:|.:..||  :|.:.|.|.....| |..
  Fly   472 PQHRGQRHQQQHRPSNEDTDHTDSHNPSDISAPSTRRNSEEDNAA--VPPMEQNTGGEEEP-LPP 533

  Fly   440 QTALNTIPHSPQPEASFSTQLVSQTFDCPQPQEQAVAKAPNSPSLPKEDPNTLLVLKSGFQ---- 500
            :.::...|:.    .:|.....|:......|:....:..||.....::|   |..|..|::
  Fly   534 RWSMQVAPNG----RTFFIDHASRRTTWIDPRNGRASPMPNQTRRVEDD---LGPLPEGWEERVH 591

  Fly   501 CPGEPFFYLVIYEFEHGTCMGECIGTCVLRFKEDDPRIQDTSQA 544
            ..|..|:      .:|.|...:.          :|||:.:.:.|
  Fly   592 TDGRVFY------IDHNTRTTQW----------EDPRLSNPNIA 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600
		PHD_SF	224..>260	CDD:304600	9/44 (20%)
		PARM	318..>491	CDD:293666	47/254 (19%)
Nedd4	NP_648993.1	C2_NEDD4_NEDD4L	71..204	CDD:175999
		WW	248..277	CDD:278809	9/45 (20%)
		WW	531..560	CDD:278809	4/32 (13%)
		WW	581..613	CDD:197736	8/47 (17%)
		HECTc	650..1003	CDD:238033
		HECTc	674..1003	CDD:214523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910