DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pie and Lpt

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster

Alignment Length:	394	Identity:	80/394 - (20%)
Similarity:	129/394 - (32%)	Gaps:	109/394 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VHYFCLLLSTHLPQRGGDSSGILGFLLRDIREEAAAAEKRKCWYCNKIGASLQCD-RCRSLFHLK 96
            ||..|::.|....|. .|:.|..      .....|...::||.:|.:.|||:.|. .||.:.|..
  Fly   113 VHRMCIMWSLRKSQI-SDADGAY------FATHFAEFLEQKCNFCGRYGASINCKMNCRQVHHWP 170

  Fly    97 CG--------LENRAVF---------EFCGQYKSYCYKCRPMDDYKRQLQSNPPRNATCPICFSS 144
            |.        ||:..||         ..|......|..|..:.|..:.:.        |..|...
  Fly   171 CAAAAGCLLILESFTVFCTEHLSQVPVICSDNNVECLSCSSLGDLSKLIM--------CSTCGDH 227

  Fly   145 IYKVELHCVVYGDCCRLGFAHKKCMRQYALTSGY-YLRCIWCRSERFRDSIRLQSVFVPDRDATW 208
            .:..   |:        |.|:....|     ||: ..||..|:..|.:||          .|..:
  Fly   228 FHST---CI--------GLANLPDTR-----SGWNCARCTKCQICRQQDS----------NDTKY 266

  Fly   209 EKQRNAYRELHERNL------------KCDQPNC-LC-------PSGRTYNRLSWVILCCSSC-A 252
            .|.....:..|...|            ||::  | :|       |.|.:.:|.......|.|| .
  Fly   267 VKCEQCQKTYHASCLRPVISAIPKYGWKCNR--CRVCTDCGSRTPGGGSSSRWHSHYTICDSCYQ 329

  Fly   253 ATSAHLKCLV--GALRLPKKRERTDFKCSMCLDVERRIAEGPARTT-----EETNADGDNQVDGS 310
            ..:....|.:  .|.|....:|..  |||.|........:..|..|     :|.|.|.|
  Fly   330 QRNKGFSCPICQKAYRAASHKEMV--KCSWCNKFVHSTCDEEADLTAYHKKKEQNPDYD------ 386

  Fly   311 FYV------QKLGPDAATRSLTQTPVFSEEDESERSS----NITVIFSQPKSNATSERLSLSPPQ 365
             ||      ...||.::.:::....:.:.:..||:.|    .:..:..:|..:.:|:.|...|..
  Fly   387 -YVCPNCKSNSSGPGSSQQTIDSIVLSAMDSSSEQLSLKEIELDPLEGKPTMDPSSDELHKLPTG 450

  Fly   366 EEMI 369
            ::.:
  Fly   451 KKKV 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600	25/101 (25%)
		PHD_SF	224..>260	CDD:304600	10/44 (23%)
		PARM	318..>491	CDD:293666	8/56 (14%)
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135	23/84 (27%)
		PHD1_KMT2C_like	205..250	CDD:276984	11/68 (16%)
		PHD2_KMT2C_like	252..298	CDD:276985	10/57 (18%)
		PHD_SF	337..392	CDD:304600	16/63 (25%)
		PHD4_KMT2C_like	530..578	CDD:276987
		PHD5_KMT2C_like	580..625	CDD:276988
		PHD6_KMT2C_like	657..707	CDD:276989
		NHP6B	1101..>1237	CDD:227935
		HMG	1173..1231	CDD:197700
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910