DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pie and Phf7

DIOPT Version :9

Sequence 1:	NP_001260348.1	Gene:	pie / 44315	FlyBaseID:	FBgn0005683	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001012211.1	Gene:	Phf7 / 364510	RGDID:	1308638	Length:	380	Species:	Rattus norvegicus

Alignment Length:	374	Identity:	117/374 - (31%)
Similarity:	181/374 - (48%)	Gaps:	57/374 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CLICKYSDTDDLVFGEWMIVRNLQVHYFCLLLSTHLPQRGGDSSGILGFLLRDIREEAAAAEKRK 73
            ||:|.....|....||::...||.||||||:||:.|||:|..:.|:.||:..||::|||.|.::.
  Rat    33 CLLCFQEPGDPEKLGEFLQKDNLCVHYFCLILSSKLPQKGQPNRGLHGFMPEDIKKEAARASRKV 97

  Fly    74 CWYCNKIGASLQC--DRCRSLFHLKCGLENRAVFEFCGQYKSYCYKCRPMDD-YKRQLQSNPPRN 135
            |:.|.:.||:::|  |:|...|||.||.|...:.:|.|:|||||.|.||..: ::|..      .
  Rat    98 CFVCKRKGAAIRCQKDQCVQNFHLPCGQERGCLSQFFGEYKSYCGKHRPTQNIHQRSF------G 156

  Fly   136 ATCPICFSSIYKVELHCVVYGDCCRLGFAHKKCMRQYALTSG-YYLRCIWCRS-ERFRDSIRLQS 198
            .:|.:|...:.:..:. .:...||.....|:||:::||.||. ::.:|..|.: |.|...:....
  Rat   157 ESCVLCCEDLSRASVE-NIRSPCCSQAIYHRKCIQKYAHTSAKHFFKCPQCNNREEFPQEMLRMG 220

  Fly   199 VFVPDRDATWEKQRNAYRELHERNLKCDQPNCLCPSGRT--YNRLSWVILCCSSCAATSAHLKCL 261
            :.:|||||.||.:..|:.||::|...||.|.||...||.  .:...|.::.|::|.:...|..|
  Rat   221 IHIPDRDAAWELEPGAFSELYQRYQHCDAPICLYEQGRDSFEDEGRWRLILCATCGSHGTHRDC- 284

  Fly   262 VGALRLPKKRERTDFKCSMCLDVERRIAEGPARTTEETNAD-GD--------------------N 305
             .:||...|:    ::|:.||         ||.|.:..:.: ||                    .
  Rat   285 -SSLRPNSKK----WECNECL---------PASTEDSVSENLGDTPCCSSTFCPHEPFLRATSLE 335

  Fly   306 QVDGSFYVQKLGPDAATRSLTQTPVFSEED--ESERSSNITVIFSQPKS 352
            :..||.:...|.|     ||.:.|..|...  :|.||..|.|.....||
  Rat   336 ENPGSSWTNWLQP-----SLLEKPESSSGSSCQSWRSKGIKVTKDCKKS 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pie	NP_001260348.1	PHD_SF	9..117	CDD:304600	49/109 (45%)
		PHD_SF	224..>260	CDD:304600	11/37 (30%)
		PARM	318..>491	CDD:293666	12/37 (32%)
Phf7	NP_001012211.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		ePHD_PHF7_G2E3_like	33..144	CDD:277139	49/110 (45%)
		PHD_PHF7_G2E3_like	246..299	CDD:276971	16/58 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..380		9/28 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335114
Domainoid	1	1.000	93	1.000	Domainoid score	I7367
eggNOG	1	0.900	-	-		E2759_KOG1084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110264at33208
OrthoFinder	1	1.000	-	-		FOG0003998
OrthoInspector	1	1.000	-	-		otm45386
orthoMCL	1	0.900	-	-		OOG6_106451
Panther	1	1.100	-	-	O	PTHR12420
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3283
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.750